Short-Term Effect of Fesoterodine on Physical Function Relevant to Fall Risk in Older Women With Overactive Bladder.
Journal
Female pelvic medicine & reconstructive surgery
ISSN: 2154-4212
Titre abrégé: Female Pelvic Med Reconstr Surg
Pays: United States
ID NLM: 101528690
Informations de publication
Date de publication:
01 12 2021
01 12 2021
Historique:
entrez:
22
11
2021
pubmed:
23
11
2021
medline:
3
2
2022
Statut:
ppublish
Résumé
The aim of this study was to measure the effect of treatment with fesoterodine on physical function relevant to fall risk in older women with overactive bladder. This was a prospective cohort study of women aged 65 years or older with overactive bladder. Urinary symptoms and physical function were measured at baseline and 8 weeks after treatment with fesoterodine. Physical activity and sedentary behavior were measured subjectively using questionnaires and objectively using an accelerometer. Physical function was measured using the Short Physical Performance Battery test. We enrolled 75 women with a median age of 76 years. At baseline, bothersome urgency urinary incontinence and nocturia were reported by 55% and 81%, respectively. At baseline, participants were highly sedentary with a median of 2,118 steps daily. After treatment, urinary symptom severity and health-related quality of life subscale scores of the Overactive Bladder Questionnaire improved significantly (-22.3±24 and 17.5±19.7, respectively; P < 0.0001). The proportion of participants who self-reported a moderate-to-high level of physical activity increased from 27% to 35% after treatment (P = 0.86). However, daily steps decreased significantly (-420.2±949, P < 0.001), whereas daily sedentary time increased by 36.6±88 minutes (P < 0.001). There was no significant change in the Short Physical Performance Battery score (-0.3±2.3, P = 0.6). In older women with overactive bladder, short-term treatment with fesoterodine decreased objectively measured physical activity with no significant change in physical function. Treatment with anticholinergics may need to be supplemented with other therapies to address fall risk in older women with overactive bladder.
Identifiants
pubmed: 34807883
doi: 10.1097/SPV.0000000000001046
pii: 01436319-202112000-00009
doi:
Substances chimiques
Benzhydryl Compounds
0
fesoterodine
621G617227
Banques de données
ClinicalTrials.gov
['NCT03946124']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
759-765Subventions
Organisme : NIA NIH HHS
ID : R03 AG053277
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2021 American Urogynecologic Society. All rights reserved.
Déclaration de conflit d'intérêts
This study is supported by the Pfizer/Urology Care Foundation Urologic Research Training Award. U.U.A. is supported by a grant from the National Institute on Aging (grant/award number: R03-AG-053277). The remaining authors have declared they have no conflicts of interest.
Références
Coyne KS, Sexton CC, Vats V, et al. National community prevalence of overactive bladder in the United States stratified by sex and age. Urology 2011;77(5):1081–1087.
Foley AL, Loharuka S, Barrett JA, et al. Association between the geriatric giants of urinary incontinence and falls in older people using data from the Leicestershire MRC incontinence study. Age Ageing 2012;41(1):35–40.
Szabo SM, Gooch K, Schermer C, et al. Association between cumulative anticholinergic burden and falls and fractures in patients with overactive bladder: US-based retrospective cohort study. BMJ Open 2019;9(5):e026391.
Wagner TH, Hu TW, Bentkover J, et al. Health-related consequences of overactive bladder. Am J Manag Care 2002;8(19 Suppl):S598–S607.
Stineman MG, Streim JE. The biopsycho-ecological paradigm: a foundational theory for medicine. PM R 2010;2(11):1035–1045.
Sanses TVD, Pearson S, Davis D, et al. Physical performance measures in older women with urinary incontinence: pelvic floor disorder or geriatric syndrome? Int Urogynecol J 2021;32:305–315.
Huang AJ, Hess R, Arya LA, et al. Pharmacologic treatment for urgency-predominant urinary incontinence in women diagnosed using a simplified algorithm: a randomized trial. Am J Obstet Gynecol 2012;206(5):444.e1–444.11.
Wyndaele JJ, Goldfischer ER, Morrow JD, et al. Effects of flexible-dose fesoterodine on overactive bladder symptoms and treatment satisfaction: an open-label study. Int J Clin Pract 2009;63(4):560–567.
Chapple C, Oelke M, Kaplan SA, et al. Fesoterodine clinical efficacy and safety for the treatment of overactive bladder in relation to patient profiles: a systematic review. Curr Med Res Opin 2015;31(6):1201–1243.
Marcum ZA, Perera S, Thorpe JM, et al. Anticholinergic use and recurrent falls in community-dwelling older adults: findings from the health ABC study. Ann Pharmacother 2015;49(11):1214–1221.
Gray SL, Anderson ML, Dublin S, et al. Cumulative use of strong anticholinergics and incident dementia: a prospective cohort study. JAMA Intern Med 2015;175(3):401–407.
Coyne KS, Thompson CL, Lai JS, et al. An overactive bladder symptom and health-related quality of life short-form: validation of the OAB-q SF. Neurourol Urodyn 2015;34(3):255–263.
Borson S, Scanlan JM, Chen P, et al. The mini-cog as a screen for dementia: validation in a population-based sample. J Am Geriatr Soc 2003;51(10):1451–1454.
Coyne KS, Matza LS, Thompson CL, et al. Determining the importance of change in the Overactive Bladder Questionnaire. J Urol 2006;176(2):627–632.
Yalcin I, Bump RC. Validation of two global impression questionnaires for incontinence. Am J Obstet Gynecol 2003;189(1):98–101.
Stewart AL, Mills KM, King AC, et al. CHAMPS physical activity questionnaire for older adults: outcomes for interventions. Med Sci Sports Exerc 2001;33(7):1126–1141.
Harada ND, Chiu V, King AC, et al. An evaluation of three self-report physical activity instruments for older adults. Med Sci Sports Exerc 2001;33(6):962–970.
Hallal PC, Victora CG. Reliability and validity of the international physical activity questionnaire (IPAQ). Med Sci Sports Exerc 2004;36(3):556.
Bellettiere J, Carlson JA, Rosenberg D, et al. Gender and age differences in hourly and daily patterns of sedentary time in older adults living in retirement communities. PLoS One 2015;10(8):e0136161.
Buchner DM, Rillamas-Sun E, Di C, et al. Accelerometer-measured moderate to vigorous physical activity and incidence rates of falls in older women. J Am Geriatr Soc 2017;65(11):2480–2487.
Lauretani F, Ticinesi A, Gionti L, et al. Short-physical performance battery (SPPB) score is associated with falls in older outpatients. Aging Clin Exp Res 2019;31(10):1435–1442.
Vasunilashorn S, Coppin AK, Patel KV, et al. Use of the Short Physical Performance Battery score to predict loss of ability to walk 400 meters: analysis from the InCHIANTI study. J Gerontol A Biol Sci Med Sci 2009;64(2):223–229.
Koneru S, Shishov M, Ware A, et al. Effectively measuring adherence to medications for systemic lupus erythematosus in a clinical setting. Arthritis Rheum 2007;57(6):1000–1006.
Molina JM, Cahn P, Grinsztejn B, et al. Rilpivirine versus efavirenz with tenofovir and emtricitabine in treatment-naive adults infected with HIV-1 (ECHO): a phase 3 randomised double-blind active-controlled trial. Lancet 2011;378(9787):238–246.
Andy UU, Harvie HS, Smith AL, et al. Validation of a self-administered instrument to measure adherence to anticholinergic drugs in women with overactive bladder. Neurourol Urodyn 2015;34(5):424–428.
Chu CM, Khanijow KD, Schmitz KH, et al. Physical activity patterns and sedentary behavior in older women with urinary incontinence: an accelerometer-based study. Female Pelvic Med Reconstr Surg 2019;25(4):318–322.
Sun F, Norman IJ, While AE. Physical activity in older people: a systematic review. BMC Public Health 2013;13:449.
McAuley E, Szabo A, Gothe N, et al. Self-efficacy: implications for physical activity, function, and functional limitations in older adults. Am J Lifestyle Med 2011;5(4). doi:10.1177/1559827610392704.
doi: 10.1177/1559827610392704
Marcus BH, Simkin LR. The stages of exercise behavior. J Sports Med Phys Fitness 1993;33(1):83–88.
Khanijow KD, Pahwa AK, Newman DK, et al. Barriers to exercise among women with urgency urinary incontinence: patient and provider perspectives. Female Pelvic Med Reconstr Surg 2018;24(4):301–306.