Metabolomics in the understanding and management of hepatic encephalopathy.
Cirrhosis
Encephalopathy
Hepatic encephalopathy
Mass spectrometry
Metabolomics
Journal
Analytical biochemistry
ISSN: 1096-0309
Titre abrégé: Anal Biochem
Pays: United States
ID NLM: 0370535
Informations de publication
Date de publication:
01 01 2022
01 01 2022
Historique:
received:
24
06
2021
revised:
30
09
2021
accepted:
16
11
2021
pubmed:
23
11
2021
medline:
27
1
2022
entrez:
22
11
2021
Statut:
ppublish
Résumé
Metabolomics refers to the study of biological components below 1000 Daltons (Da) involved in metabolic pathways as substrates, products or effectors. According to the interconnected metabolic disturbances that have been described in the pathophysiology of hepatic encephalopathy (HE), this technique appears to be well adapted to study and better delineate the disease. This review will focus on recent advances in metabolomics in the field of HE. Thus, after a brief overview of the general principles of metabolomics, we will discuss metabolomics as a potentially efficient tool for unraveling new HE pathophysiological insights, biomarkers identification, or as a predicting tool for treatment response or outcome prognosis. Finally, we will give our vision on the prospects offered by metabolomics for improving care of HE patients.
Identifiants
pubmed: 34808106
pii: S0003-2697(21)00378-X
doi: 10.1016/j.ab.2021.114477
pii:
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
114477Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.