An updated review on the potential antineoplastic actions of oleuropein.
antineoplastic
cell apoptosis
cell proliferation
molecular mechanism
oleuropein
Journal
Phytotherapy research : PTR
ISSN: 1099-1573
Titre abrégé: Phytother Res
Pays: England
ID NLM: 8904486
Informations de publication
Date de publication:
Jan 2022
Jan 2022
Historique:
revised:
20
10
2021
received:
13
08
2021
accepted:
26
10
2021
pubmed:
23
11
2021
medline:
27
1
2022
entrez:
22
11
2021
Statut:
ppublish
Résumé
Oleuropein is an ester of elenolic acid and hydroxytyrosol (3, 4-dihydroxyphenylethanol). It is a phenolic compound and the most luxuriant in olives. The detailed information related to the anticancer effects of oleuropein was collected from the internet database PubMed/Medline, ResearchGate, Web of Science, Wiley Online Library, and Cnki using appropriate keywords until the end of October 2021. Oleuropein has been shown to have antioxidant, anticancer, antiinflammatory, cardioprotective, neuroprotective, and hepatoprotective effects. Previous studies also revealed that oleuropein could effectively inhibit the malignant progression of esophageal cancer, gastric cancer, breast cancer, lung cancer, liver cancer, pancreatic cancer, ovarian cancer, prostate cancer, and cervical cancer. Recently, the role of oleuropein in inhibiting tumor cell proliferation, invasion, and migration and inducing tumor cell apoptosis has gained extensive attention. In this review, we have summarized the latest research progress related to the antioncogenic mechanisms and the potential role of oleuropein in targeting different human malignancies. Based on these findings, it can be concluded that oleuropein can function as a promising chemopreventive and chemotherapeutic agent against cancer, but its more detailed anticancer effects and underlying mechanisms need to be further validated in future preclinical as well as clinical studies.
Substances chimiques
Antineoplastic Agents
0
Iridoid Glucosides
0
Iridoids
0
oleuropein
2O4553545L
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
365-379Subventions
Organisme : National Research Foundation of Korea
ID : NRF-2021R1I1A2060024
Informations de copyright
© 2021 John Wiley & Sons Ltd.
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