Nucleases as molecular targets for cancer diagnosis.
Nuclease
Nuclease activity
Nucleic acid probes, novel diagnostics
cancer biomarkers
cancer diagnostics
Journal
Biomarker research
ISSN: 2050-7771
Titre abrégé: Biomark Res
Pays: England
ID NLM: 101607860
Informations de publication
Date de publication:
22 Nov 2021
22 Nov 2021
Historique:
received:
20
08
2021
accepted:
03
11
2021
entrez:
23
11
2021
pubmed:
24
11
2021
medline:
24
11
2021
Statut:
epublish
Résumé
Early cancer diagnosis is a crucial element to improved treatment options and survival. Great research efforts have been made in the search for better performing cancer diagnostic biomarkers. However, the quest continues as novel biomarkers with high accuracy for an early diagnosis remain an unmet clinical need. Nucleases, which are enzymes capable of cleaving nucleic acids, have been long considered as potential cancer biomarkers. The implications of nucleases are key for biological functions, their presence in different cellular counterparts and catalytic activity led the enthusiasm towards investigating the role of nucleases as promising cancer biomarkers. However, the most essential feature of these proteins, which is their enzymatic activity, has not been fully exploited. This review discusses nucleases interrogated as cancer biomarkers, providing a glimpse of their physiological roles. Moreover, it highlights the potential of harnessing the enzymatic activity of cancer-associated nucleases as a novel diagnostic biomarker using nucleic acid probes as substrates.
Identifiants
pubmed: 34809722
doi: 10.1186/s40364-021-00342-4
pii: 10.1186/s40364-021-00342-4
pmc: PMC8607607
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
86Subventions
Organisme : Knut och Alice Wallenbergs Stiftelse
ID : 301097
Informations de copyright
© 2021. The Author(s).
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