Plasticity in the Absence of NOTCH Uncovers a RUNX2-Dependent Pathway in Small Cell Lung Cancer.
Animals
CRISPR-Cas Systems
Carcinogenesis
/ genetics
Cell Line, Tumor
Cell Plasticity
/ genetics
Core Binding Factor Alpha 1 Subunit
/ metabolism
Disease Models, Animal
Humans
Loss of Function Mutation
Lung Neoplasms
/ genetics
Mice
Receptor, Notch1
/ genetics
Receptor, Notch2
/ genetics
Signal Transduction
/ genetics
Small Cell Lung Carcinoma
/ genetics
Transfection
Journal
Cancer research
ISSN: 1538-7445
Titre abrégé: Cancer Res
Pays: United States
ID NLM: 2984705R
Informations de publication
Date de publication:
15 01 2022
15 01 2022
Historique:
received:
22
06
2021
revised:
05
10
2021
accepted:
15
11
2021
pubmed:
24
11
2021
medline:
19
2
2022
entrez:
23
11
2021
Statut:
ppublish
Résumé
Neuroendocrine to nonneuroendocrine plasticity supports small cell lung cancer (SCLC) tumorigenesis and promotes immunogenicity. Approximately 20% to 25% of SCLCs harbor loss-of-function (LOF)
Identifiants
pubmed: 34810201
pii: 0008-5472.CAN-21-1991
doi: 10.1158/0008-5472.CAN-21-1991
pmc: PMC8770597
mid: NIHMS1759764
doi:
Substances chimiques
Core Binding Factor Alpha 1 Subunit
0
NOTCH1 protein, human
0
NOTCH2 protein, human
0
Notch1 protein, mouse
0
Notch2 protein, mouse
0
RUNX2 protein, human
0
Receptor, Notch1
0
Receptor, Notch2
0
Runx2 protein, mouse
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
248-263Subventions
Organisme : NCI NIH HHS
ID : K08 CA222657
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA006516
Pays : United States
Informations de copyright
©2021 American Association for Cancer Research.
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