Long-term sequelae are highly prevalent one year after hospitalization for severe COVID-19.
Aged
COVID-19
/ complications
Carbon Monoxide
/ metabolism
Female
Hospitalization
Humans
Italy
/ epidemiology
Logistic Models
Male
Mental Health
Middle Aged
Motor Activity
Patient Acuity
Patient Discharge
Prevalence
Prospective Studies
Pulmonary Diffusing Capacity
Respiratory Function Tests
Stress Disorders, Post-Traumatic
/ epidemiology
Survivors
Tomography, X-Ray Computed
Walk Test
Post-Acute COVID-19 Syndrome
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
22 11 2021
22 11 2021
Historique:
received:
25
06
2021
accepted:
07
10
2021
entrez:
23
11
2021
pubmed:
24
11
2021
medline:
15
12
2021
Statut:
epublish
Résumé
Many coronavirus disease 2019 (Covid-19) survivors show symptoms months after acute illness. The aim of this work is to describe the clinical evolution of Covid-19, one year after discharge. We performed a prospective cohort study on 238 patients previously hospitalized for Covid-19 pneumonia in 2020 who already underwent clinical follow-up 4 months post-Covid-19. 200 consented to participate to a 12-months clinical assessment, including: pulmonary function tests with diffusing lung capacity for carbon monoxide (DLCO); post-traumatic stress (PTS) symptoms evaluation by the Impact of Event Scale (IES); motor function evaluation (by Short Physical Performance Battery and 2 min walking test); chest Computed Tomography (CT). After 366 [363-369] days, 79 patients (39.5%) reported at least one symptom. A DLCO < 80% was observed in 96 patients (49.0%). Severe DLCO impairment (< 60%) was reported in 20 patients (10.2%), related to extent of CT scan abnormalities. Some degree of motor impairment was observed in 25.8% of subjects. 37/200 patients (18.5%) showed moderate-to-severe PTS symptoms. In the time elapsed from 4 to 12 months after hospital discharge, motor function improves, while respiratory function does not, being accompanied by evidence of lung structural damage. Symptoms remain highly prevalent one year after acute illness.
Identifiants
pubmed: 34811387
doi: 10.1038/s41598-021-01215-4
pii: 10.1038/s41598-021-01215-4
pmc: PMC8608998
doi:
Substances chimiques
Carbon Monoxide
7U1EE4V452
Types de publication
Journal Article
Observational Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
22666Informations de copyright
© 2021. The Author(s).
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