Presenilin is involved in larval-pupal metamorphosis development of Bombyx mori.
Bombyx mori
CRISPR/Cas9
Hippo pathway
metamorphosis
presenilin
Journal
Archives of insect biochemistry and physiology
ISSN: 1520-6327
Titre abrégé: Arch Insect Biochem Physiol
Pays: United States
ID NLM: 8501752
Informations de publication
Date de publication:
Apr 2022
Apr 2022
Historique:
revised:
09
11
2021
received:
19
08
2021
accepted:
11
11
2021
pubmed:
24
11
2021
medline:
17
3
2022
entrez:
23
11
2021
Statut:
ppublish
Résumé
Disruption of the presenilin (ps) genes are the major genetic cause of familial Alzheimer's disease. The silkworm, Bombyx mori (B. mori), is an important model insect. The ps homologue gene in B. mori was identified and characterized. However, the role of ps in B. mori was poorly understood. Here, we found that Bmps was ubiquitously expressed in all the tested tissues during metamorphosis. In the current study, loss-of-function analysis of Bmps was performed by the binary transgenic CRISPR/cas9 system. Compared with the wild type, the developmental time of ∆Bmps animals were significantly delayed. In addition, ∆Bmps showed abnormal appendage including antenna, leg, wing and eye during pupal and adult stages. RNA-seq analysis indicated that apoptosis and proliferation related pathways were affected in ∆Bmps. Moreover, the Hippo pathway was affected by Bmps depletion in brain and wing disc. Our results suggest that PS is essential for maintaining the dynamic balance of apoptosis and proliferation during metamorphosis.
Substances chimiques
Insect Proteins
0
Presenilins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e21855Subventions
Organisme : National Postdoctoral Program for Innovative Talents Grant
ID : BX20190350
Organisme : China Postdoctoral Science Foundation Grant
ID : 2019M661654
Organisme : Natural Science Foundation of Shanghai
ID : 16ZR1412300
Organisme : National Natural Science Foundation of China
ID : 31172147
Informations de copyright
© 2021 Wiley Periodicals LLC.
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