Microbiota links to neural dynamics supporting threat processing.
Adult
Conditioning, Classical
/ physiology
Connectome
Fear
/ physiology
Female
Gastrointestinal Microbiome
/ physiology
Gyrus Cinguli
/ diagnostic imaging
Humans
Insular Cortex
/ diagnostic imaging
Magnetic Resonance Imaging
Male
Models, Theoretical
Nerve Net
/ diagnostic imaging
RNA, Ribosomal, 16S
Young Adult
anterior insula
dorsal anterior cingulate
gut-brain axis
microbiota
neuroimaging
threat processing
Journal
Human brain mapping
ISSN: 1097-0193
Titre abrégé: Hum Brain Mapp
Pays: United States
ID NLM: 9419065
Informations de publication
Date de publication:
01 02 2022
01 02 2022
Historique:
revised:
22
08
2021
received:
27
04
2021
accepted:
25
09
2021
pubmed:
24
11
2021
medline:
29
3
2022
entrez:
23
11
2021
Statut:
ppublish
Résumé
There is growing recognition that the composition of the gut microbiota influences behaviour, including responses to threat. The cognitive-interoceptive appraisal of threat-related stimuli relies on dynamic neural computations between the anterior insular (AIC) and the dorsal anterior cingulate (dACC) cortices. If, to what extent, and how microbial consortia influence the activity of this cortical threat processing circuitry is unclear. We addressed this question by combining a threat processing task, neuroimaging, 16S rRNA profiling and computational modelling in healthy participants. Results showed interactions between high-level ecological indices with threat-related AIC-dACC neural dynamics. At finer taxonomic resolutions, the abundance of Ruminococcus was differentially linked to connectivity between, and activity within the AIC and dACC during threat updating. Functional inference analysis provides a strong rationale to motivate future investigations of microbiota-derived metabolites in the observed relationship with threat-related brain processes.
Identifiants
pubmed: 34811847
doi: 10.1002/hbm.25682
pmc: PMC8720184
doi:
Substances chimiques
RNA, Ribosomal, 16S
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
733-749Informations de copyright
© 2021 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.
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