Human Leukocyte Antigens -DQA1 and -DQB1 Alleles in Patients With Common Warts.
association
hla
hpv
polymorphism
skin warts
Journal
Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737
Informations de publication
Date de publication:
Oct 2021
Oct 2021
Historique:
accepted:
19
10
2021
entrez:
23
11
2021
pubmed:
24
11
2021
medline:
24
11
2021
Statut:
epublish
Résumé
Introduction The human papillomavirus induces the formation of lesions in different epithelia. Several studies describe an association of class II human leukocyte antigen with genital lesions, implying that they could also be related to the presence of common warts. The goal of this work was to determine the frequency of human leukocyte antigens (HLA)-DQA1 and HLA-DQB1 in Mexicans with common warts. Methods Thirty-two patients with a diagnosis of common warts, without any other systemic disease, and 100 healthy subjects from the same geographic area were recruited. The second exon of the HLA-DQA1 and HLA-DQB1 loci was typed by dot-blot and chemiluminescence. Results Alleles DQA1*03:01:01 (P = 0.021) and DQB1*03:02 (P = 0.036) were associated with the presence of skin warts. DQA1*04:01-DQB1*04:02 (P = 0.009) and DQA1*03:01:01-DQB1*03:02 (P = 0.044) were the most frequent haplotypes in patients. Conclusion In conclusion, the results of our study showed that the alleles DQA1 *03:01:01, DQB1*03:02, DQA1 *04:01, and DQB1*04:02 were associated with susceptibility to common warts, while DQA1*05:01 was significantly diminished in them. Consequently, the haplotypes DQA1*04:01-DQB1*04: 02 and DQA1*03:01:01-DQB1*03:02 were found to be associated with susceptibility, and DQA1*05:01-DQB1*03:01 increased significantly in controls. Therefore, the alleles of the DQA1 and DQB1 genes that are associated with susceptibility could be presenting human papillomavirus (HPV) peptides to T lymphocytes that activate a Th2-type response (anti-inflammatory cytokines), which allows the development of skin warts in this population.
Identifiants
pubmed: 34812317
doi: 10.7759/cureus.18933
pmc: PMC8604088
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e18933Informations de copyright
Copyright © 2021, Sánchez-Barrientos et al.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Cold Spring Harb Protoc. 2017 Jul 5;2017(7):pdb.prot093468
pubmed: 28679704
Cutis. 2004 Jun;73(6):379-84
pubmed: 15224780
Infect Genet Evol. 2014 Jan;21:220-6
pubmed: 24291228
J Med Virol. 2017 May;89(5):902-907
pubmed: 27736001
Int J Dermatol. 2010 Dec;49(12):1376-9
pubmed: 21155086
ISRN Dermatol. 2012;2012:351603
pubmed: 23097714
Otolaryngol Pol. 2014 Sep-Oct;68(5):213-9
pubmed: 25283316
Int J Dermatol. 1988 Jun;27(5):322-6
pubmed: 2839432
Br J Cancer. 2000 Apr;82(7):1348-52
pubmed: 10755413
Indian Dermatol Online J. 2020 Sep 19;11(5):784-788
pubmed: 33235846
Arch Dermatol Res. 2004 Aug;296(3):105-11
pubmed: 15257408
Lancet Oncol. 2009 Apr;10(4):321-2
pubmed: 19350698
J Infect Dis. 2016 Jun 1;213(11):1717-24
pubmed: 26908737
J Infect Dis. 2002 Dec 1;186(11):1565-74
pubmed: 12447731
Virology. 2013 Oct;445(1-2):2-10
pubmed: 23683837
J Infect Dis. 2001 Nov 15;184(10):1310-4
pubmed: 11679920
Int J Cancer. 2008 Feb 1;122(3):486-94
pubmed: 17955486
Hum Mol Genet. 2015 May 1;24(9):2681-8
pubmed: 25616963
Br J Dermatol. 2015 Jan;172(1):196-201
pubmed: 24976535
Infect Genet Evol. 2019 Mar;68:194-202
pubmed: 30590170
Biomed Pharmacother. 2015 Jul;73:58-64
pubmed: 26211583
Br J Dermatol. 2009 Jul;161(1):148-52
pubmed: 19438464
J Virol. 2016 May 12;90(11):5503-5513
pubmed: 27030261
J Med Virol. 2005 Sep;77(1):107-12
pubmed: 16032719
Vaccine. 2006 Mar 30;24 Suppl 1:S16-22
pubmed: 16219398