Adipocyte-derived exosomes may promote breast cancer progression in type 2 diabetes.
Journal
Science signaling
ISSN: 1937-9145
Titre abrégé: Sci Signal
Pays: United States
ID NLM: 101465400
Informations de publication
Date de publication:
23 Nov 2021
23 Nov 2021
Historique:
entrez:
23
11
2021
pubmed:
24
11
2021
medline:
18
1
2022
Statut:
ppublish
Résumé
Obesity and metabolic diseases, such as insulin resistance and type 2 diabetes (T2D), are associated with metastatic breast cancer in postmenopausal women. Here, we investigated the critical cellular and molecular factors behind this link. We found that primary human adipocytes shed extracellular vesicles, specifically exosomes, that induced the expression of genes associated with epithelial-to-mesenchymal transition (EMT) and cancer stem–like cell (CSC) traits in cocultured breast cancer cell lines. Transcription of these genes was further increased in cells exposed to exosomes shed from T2D patient–derived adipocytes or insulin-resistant adipocytes and required the epigenetic reader proteins BRD2 and BRD4 in recipient cells. The thrombospondin family protein TSP5, which is associated with cancer, was more abundant in exosomes from T2D or insulin-resistant adipocytes and partially contributed to EMT in recipient cells. Bioinformatic analysis of breast cancer patient tissue showed that greater coexpression of
Identifiants
pubmed: 34813359
doi: 10.1126/scisignal.abj2807
pmc: PMC8765301
mid: NIHMS1768428
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
eabj2807Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK117161
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA243004
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA182898
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA222170
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK046200
Pays : United States
Commentaires et corrections
Type : CommentIn
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