Vibrational spectroscopy analysis of ligand efficacy in human M

Humans Ligands Receptor, Muscarinic M2 / chemistry Spectrum Analysis

Journal

Communications biology
ISSN: 2399-3642
Titre abrégé: Commun Biol
Pays: England
ID NLM: 101719179

Informations de publication

Date de publication:
23 11 2021
Historique:
received: 11 04 2021
accepted: 01 11 2021
entrez: 24 11 2021
pubmed: 25 11 2021
medline: 25 12 2021
Statut: epublish

Résumé

The intrinsic efficacy of ligand binding to G protein-coupled receptors (GPCRs) reflects the ability of the ligand to differentially activate its receptor to cause a physiological effect. Here we use attenuated total reflection-Fourier transform infrared (ATR-FTIR) spectroscopy to examine the ligand-dependent conformational changes in the human M

Identifiants

DOI: 10.1038/s42003-021-02836-1 PMID: 34815515 PMC: PMC8635417
pubmed: 34815515
doi: 10.1038/s42003-021-02836-1
pii: 10.1038/s42003-021-02836-1
pmc: PMC8635417
doi:

Substances chimiques

CHRM2 protein, human 0
Ligands 0
Receptor, Muscarinic M2 0

Banques de données

figshare
['10.6084/m9.figshare.16608511']

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1321

Subventions

Organisme : MEXT | Japan Society for the Promotion of Science (JSPS)
ID : 18K14662
Organisme : MEXT | Japan Science and Technology Agency (JST)
ID : JPMJPR19G4

Informations de copyright

© 2021. The Author(s).

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Auteurs

Kota Katayama (K)

Department of Life Science and Applied Chemistry, Nagoya Institute of Technology, Showa-ku, Nagoya, 466-8555, Japan. Katayama.kota@nitech.ac.jp.
OptoBioTechnology Research Center, Nagoya Institute of Technology, Showa-ku, Nagoya, 466-8555, Japan. Katayama.kota@nitech.ac.jp.
PRESTO, Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchi, Saitama, 332-0012, Japan. Katayama.kota@nitech.ac.jp.
ORCID: 0000-0001-8498-4374

Kohei Suzuki (K)

Department of Life Science and Applied Chemistry, Nagoya Institute of Technology, Showa-ku, Nagoya, 466-8555, Japan.

Ryoji Suno (R)

Department of Medical Chemistry, Kansai Medical University, Hirakata, 573-1010, Japan.

Ryoji Kise (R)

Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Miyagi, 980-8578, Japan.

Hirokazu Tsujimoto (H)

Department of Cell Biology and Medical Chemistry, Graduate School of Medicine, Kyoto University, Kyoto, 606-8501, Japan.

So Iwata (S)

Department of Cell Biology and Medical Chemistry, Graduate School of Medicine, Kyoto University, Kyoto, 606-8501, Japan.

Asuka Inoue (A)

Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Miyagi, 980-8578, Japan.
ORCID: 0000-0003-0805-4049

Takuya Kobayashi (T)

Department of Medical Chemistry, Kansai Medical University, Hirakata, 573-1010, Japan.
Japan Agency for Medical Research and Development, Core Research for Evolutional Science and Technology (AMED-CREST), Chiyoda-ku, Tokyo, 100-0004, Japan.

Hideki Kandori (H)

Department of Life Science and Applied Chemistry, Nagoya Institute of Technology, Showa-ku, Nagoya, 466-8555, Japan. kandori@nitech.ac.jp.
OptoBioTechnology Research Center, Nagoya Institute of Technology, Showa-ku, Nagoya, 466-8555, Japan. kandori@nitech.ac.jp.
ORCID: 0000-0002-4922-1344

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Vibrational spectroscopy analysis of ligand...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Ligands › Vibrational spectroscopy analysis of ligand...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs cholinergiques › Récepteur muscarinique › Récepteur muscarinique de type M2 › Vibrational spectroscopy analysis of ligand...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse spectrale › Vibrational spectroscopy analysis of ligand...