Effects of the association of high fluoride- and calcium-containing caries-preventive agents with regular or high fluoride toothpaste on enamel: an in vitro study.
Adolescent
Animals
Calcium
/ pharmacology
Cariostatic Agents
/ pharmacology
Cattle
Child
Dental Caries
/ prevention & control
Dental Caries Susceptibility
Dental Enamel
Dentifrices
/ pharmacology
Fluorides
/ pharmacology
Humans
Sodium Fluoride
/ pharmacology
Tooth Remineralization
Toothpastes
/ pharmacology
CPP-ACP
Demineralization
Enamel
Fluoride
In vitro
SDF
Varnish
pH-cycling
Journal
Clinical oral investigations
ISSN: 1436-3771
Titre abrégé: Clin Oral Investig
Pays: Germany
ID NLM: 9707115
Informations de publication
Date de publication:
Mar 2022
Mar 2022
Historique:
received:
21
09
2021
accepted:
15
11
2021
pubmed:
25
11
2021
medline:
9
3
2022
entrez:
24
11
2021
Statut:
ppublish
Résumé
The aim of this in vitro study was to compare the caries-preventive effect of various high fluoride- and calcium-containing caries-preventive agents (> 22.000 ppm F Bovine enamel specimens (n = 276; 5 mm × 3.5 mm × 3 mm) having one sound surface [ST] and one artificial caries lesion [DT] were randomly allocated to 12 groups. Interventions before pH-cycling were no intervention ([SC After pH-cycling, SC Under the conditions chosen, all fluoride varnishes/solutions significantly reduced demineralization. Furthermore, a significant dose-response characteristic for fluoride varnishes could be revealed. However, no additional benefit could be observed, when varnishes were combined with high fluoride instead of regular fluoride dentifrices. For children and adolescents with high caries risks varnishes containing more than 22,600 ppm should be further investigated, as they offered higher caries-preventive effects in vitro. Furthermore, there seems to be no difference in the demineralization-inhibitory capacity of fluoride varnishes when used in combination with either standard or highly fluoridated dentifrices.
Identifiants
pubmed: 34816310
doi: 10.1007/s00784-021-04299-4
pii: 10.1007/s00784-021-04299-4
doi:
Substances chimiques
Cariostatic Agents
0
Dentifrices
0
Toothpastes
0
Sodium Fluoride
8ZYQ1474W7
Fluorides
Q80VPU408O
Calcium
SY7Q814VUP
Types de publication
Journal Article
Langues
eng
Pagination
3167-3178Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
Références
Pessan JP, Toumba KJ, Buzalaf MAR (2011) Topical use of fluorides for caries control. Monogr Oral Sci 22:115–132. https://doi.org/10.1159/000325154
doi: 10.1159/000325154
pubmed: 21701195
Ogard B, Seppa L, Rolla G (1994) Professional topical fluoride applications–clinical efficacy and mechanism of action. Adv Dent Res 8:190–201. https://doi.org/10.1177/08959374940080021001
doi: 10.1177/08959374940080021001
pubmed: 7865075
Marinho VC, Worthington HV, Walsh T and Clarkson JE (2013) Fluoride varnishes for preventing dental caries in children and adolescents. Cochrane Database Syst Rev:CD002279. https://doi.org/10.1002/14651858.CD002279.pub2
Karlinsey RL, Mackey AC, Walker TJ, Frederick KE, Blanken DD, Flaig SM, Walker ER (2011) In vitro remineralization of human and bovine white-spot enamel lesions by NaF dentifrices: a pilot study. J Dent Oral Hyg 3:22–29
pubmed: 21643437
pmcid: 3105352
Mohd Said SN, Ekambaram M, Yiu CK (2017) Effect of different fluoride varnishes on remineralization of artificial enamel carious lesions. Int J Paediatr Dent 27:163–173. https://doi.org/10.1111/ipd.12243
doi: 10.1111/ipd.12243
pubmed: 27348852
Reynolds EC (1997) Remineralization of enamel subsurface lesions by casein phosphopeptide-stabilized calcium phosphate solutions. J Dent Res 76:1587–95. https://doi.org/10.1177/00220345970760091101
doi: 10.1177/00220345970760091101
pubmed: 9294493
Attin T, Hartmann O, Hilgers RD, Hellwig E (1995) Fluoride retention of incipient enamel lesions after treatment with a calcium fluoride varnish in vivo. Arch Oral Biol 40:169–74. https://doi.org/10.1016/0003-9969(95)98804-8
doi: 10.1016/0003-9969(95)98804-8
pubmed: 7605244
Erdwey D, Meyer-Lueckel H, Esteves-Oliveira M, Apel C, Wierichs RJ (2021) Demineralization Inhibitory effects of highly concentrated fluoride dentifrice and fluoride gels/solutions on sound dentin and artificial dentin caries lesions in vitro. Caries Res 55:41–54. https://doi.org/10.1159/000509931
doi: 10.1159/000509931
pubmed: 33285548
Rosenblatt A, Stamford TC, Niederman R (2009) Silver diamine fluoride: a caries “silver-fluoride bullet.” J Dent Res 88:116–25. https://doi.org/10.1177/0022034508329406
doi: 10.1177/0022034508329406
pubmed: 19278981
Delbem AC, Bergamaschi M, Sassaki KT, Cunha RF (2006) Effect of fluoridated varnish and silver diamine fluoride solution on enamel demineralization: pH-cycling study. J Appl Oral Sci 14:88–92. https://doi.org/10.1590/s1678-77572006000200005
doi: 10.1590/s1678-77572006000200005
pubmed: 19089037
pmcid: 4327448
Yu OY, Mei ML, Zhao IS, Li QL, Lo EC, Chu CH (2018) Remineralisation of enamel with silver diamine fluoride and sodium fluoride. Dent Mater 34:e344–e352. https://doi.org/10.1016/j.dental.2018.10.007
doi: 10.1016/j.dental.2018.10.007
pubmed: 30482611
Wierichs RJ, Stausberg S, Lausch J, Meyer-Lueckel H, Esteves-Oliveira M (2018) Caries-Preventive Effect of NaF, NaF plus TCP, NaF plus CPP-ACP, and SDF varnishes on sound dentin and artificial dentin caries in vitro. Caries Res 52:199–211. https://doi.org/10.1159/000484483
doi: 10.1159/000484483
pubmed: 29339648
Pithon MM, Dos Santos MJ, Andrade CS, Leao Filho JC, Braz AK, de Araujo RE, Tanaka OM, Fidalgo TK, Dos Santos AM, Maia LC (2015) Effectiveness of varnish with CPP-ACP in prevention of caries lesions around orthodontic brackets: an OCT evaluation. Eur J Orthod 37:177–82. https://doi.org/10.1093/ejo/cju031
doi: 10.1093/ejo/cju031
pubmed: 24997026
Gluzman R, Katz RV, Frey BJ, McGowan R (2013) Prevention of root caries: a literature review of primary and secondary preventive agents. Spec Care Dentist 33:133–40. https://doi.org/10.1111/j.1754-4505.2012.00318.x
doi: 10.1111/j.1754-4505.2012.00318.x
pubmed: 23600985
Twetman S, Keller MK (2016) Fluoride rinses, gels and foams: an update of controlled clinical trials. Caries Res 50(Suppl 1):38–44. https://doi.org/10.1159/000439180
doi: 10.1159/000439180
pubmed: 27101002
Central German Ethics Committee (2003) The use of human body materials for the purpose of medical research (in German). https://www.zentrale-ethikkommission.de/stellungnahmen/koerpermaterialien/ . Accessed 21 Nov 2021
Meyer-Lueckel H, Wierichs RJ, Gninka B, Heldmann P, Dorfer CE, Paris S (2015) The effect of various model parameters on enamel caries lesions in a dose-response model in situ. J Dent 43:1261–7. https://doi.org/10.1016/j.jdent.2015.08.003
doi: 10.1016/j.jdent.2015.08.003
pubmed: 26275928
Buskes JA, Christoffersen J, Arends J (1985) Lesion formation and lesion remineralization in enamel under constant composition conditions. A new technique with applications. Caries Res 19:490–6. https://doi.org/10.1159/000260887
doi: 10.1159/000260887
pubmed: 3865704
Wierichs RJ, Kogel J, Lausch J, Esteves-Oliveira M, Meyer-Lueckel H (2017) Effects of self-assembling peptide P11–4, fluorides, and caries infiltration on artificial enamel caries lesions in vitro. Caries Res 51:451–459. https://doi.org/10.1159/000477215
doi: 10.1159/000477215
pubmed: 28772269
Jansen EE, Meyer-Lueckel H, Esteves-Oliveira M, Wierichs RJ (2021) Do bleaching gels affect the stability of the masking and caries-arresting effects of caries infiltration-in vitro. Clin Oral Investig 25:4011–4021. https://doi.org/10.1007/s00784-020-03732-4
doi: 10.1007/s00784-020-03732-4
pubmed: 33319337
Wierichs RJ, Rupp K, Meyer-Lueckel H, Apel C, Esteves-Oliveira M (2020) Effects of dentifrices differing in fluoride content on remineralization characteristics of dentin in vitro. Caries Res 54:75–86. https://doi.org/10.1159/000504165
doi: 10.1159/000504165
pubmed: 31775152
Esteves-Oliveira M, Santos NM, Meyer-Lueckel H, Wierichs RJ, Rodrigues JA (2017) Caries-preventive effect of anti-erosive and nano-hydroxyapatite-containing toothpastes in vitro. Clin Oral Investig 21:291–300. https://doi.org/10.1007/s00784-016-1789-0
doi: 10.1007/s00784-016-1789-0
pubmed: 26993660
Angmar B, Carlstrom D, Glas JE (1963) Studies on the ultrastructure of dental enamel. IV. The mineralization of normal human enamel. J Ultrastruct Res 8:12–23. https://doi.org/10.1016/s0022-5320(63)80017-9
doi: 10.1016/s0022-5320(63)80017-9
pubmed: 14013184
de Josselin de Jong E, ten Bosch JJ and Noordmans J, (1987) Optimised microcomputer-guided quantitative microradiography on dental mineralised tissue slices. Phys Med Biol 32:887–99. https://doi.org/10.1088/0031-9155/32/7/008
doi: 10.1088/0031-9155/32/7/008
Arends J, Dijkman T, Christoffersen J (1987) Average mineral loss in dental enamel during demineralization. Caries Res 21:249–54. https://doi.org/10.1159/000261028
doi: 10.1159/000261028
pubmed: 3471347
Theuns HM, van Dijk JW, Driessens FC, Groeneveld A (1984) The surface layer during artificial carious lesion formation. Caries Res 18:97–102. https://doi.org/10.1159/000260756
doi: 10.1159/000260756
pubmed: 6365314
Magalhaes AC, Moron BM, Comar LP, Wiegand A, Buchalla W, Buzalaf MA (2009) Comparison of cross-sectional hardness and transverse microradiography of artificial carious enamel lesions induced by different demineralising solutions and gels. Caries Res 43:474–83. https://doi.org/10.1159/000264685
doi: 10.1159/000264685
pubmed: 20016178
Marinho VC, Higgins JP, Logan S and Sheiham A (2003) Topical fluoride (toothpastes, mouthrinses, gels or varnishes) for preventing dental caries in children and adolescents. Cochrane Database Syst Rev:CD002782. https://doi.org/10.1002/14651858.CD002782
Wierichs RJ, Musiol J, Erdwey D, Esteves-Oliveira M, Apel C, Meyer-Lueckel H (2020) Re- and demineralization characteristics of dentin depending on fluoride application and baseline characteristics in situ. J Dent 94:103305. https://doi.org/10.1016/j.jdent.2020.103305
doi: 10.1016/j.jdent.2020.103305
pubmed: 32112909
Akabane S, Delbem AC, Pessan J, Garcia L, Emerenciano N, Goncalves DF, Danelon M (2018) In situ effect of the combination of fluoridated toothpaste and fluoridated gel containing sodium trimetaphosphate on enamel demineralization. J Dent 68:59–65. https://doi.org/10.1016/j.jdent.2017.10.013
doi: 10.1016/j.jdent.2017.10.013
pubmed: 29097122
PaesLeme AF, Dalcico R, Tabchoury CP, Del BelCury AA, Rosalen PL, Cury JA (2004) In situ effect of frequent sucrose exposure on enamel demineralization and on plaque composition after APF application and F dentifrice use. J Dent Res 83:71–5. https://doi.org/10.1177/154405910408300114
doi: 10.1177/154405910408300114
Fernandez CE, Tenuta LMA, Del BelCury AA, Nobrega DF, Cury JA (2017) Effect of 5,000 ppm fluoride dentifrice or 1,100 ppm fluoride dentifrice combined with acidulated phosphate fluoride on caries lesion inhibition and repair. Caries Res 51:179–187. https://doi.org/10.1159/000453624
doi: 10.1159/000453624
pubmed: 28222429
Wierichs RJ, Westphal S, Lausch J, Meyer-Lueckel H, Esteves-Oliveira M (2018) Influence of highly concentrated fluoride dentifrices on remineralization characteristics of enamel in vitro. Clin Oral Investig 22:2325–2334. https://doi.org/10.1007/s00784-018-2333-1
doi: 10.1007/s00784-018-2333-1
pubmed: 29344804
Manarelli MM, Delbem AC, Lima TM, Castilho FC, Pessan JP (2014) In vitro remineralizing effect of fluoride varnishes containing sodium trimetaphosphate. Caries Res 48:299–305. https://doi.org/10.1159/000356308
doi: 10.1159/000356308
pubmed: 24526110
Arends J, Christoffersen J (1986) The nature of early caries lesions in enamel. J Dent Res 65:2–11
doi: 10.1177/00220345860650010201
Edmunds DH, Whittaker DK, Green RM (1988) Suitability of human, bovine, equine, and ovine tooth enamel for studies of artificial bacterial carious lesions. Caries research 22:327–36
doi: 10.1159/000261132
Featherstone JD, Mellberg JR (1981) Relative rates of progress of artificial carious lesions in bovine, ovine and human enamel. Caries Res 15:109–14
doi: 10.1159/000260508
Mellberg JR (1992) Hard-tissue substrates for evaluation of cariogenic and anti-cariogenic activity in situ. Journal of dental research 71(Spec):913–9
doi: 10.1177/002203459207100S25
Magalhaes AC, Levy FM, Rios D, Buzalaf MA (2010) Effect of a single application of TiF(4) and NaF varnishes and solutions on dentin erosion in vitro. J Dent 38:153–7. https://doi.org/10.1016/j.jdent.2009.09.015
doi: 10.1016/j.jdent.2009.09.015
pubmed: 19808078
Ganss C, Schlueter N, Preiss S, Klimek J (2009) Tooth brushing habits in uninstructed adults–frequency, technique, duration and force. Clin Oral Investig 13:203–8. https://doi.org/10.1007/s00784-008-0230-8
doi: 10.1007/s00784-008-0230-8
pubmed: 18853203
Aykut-Yetkiner A, Attin T, Wiegand A (2014) Prevention of dentine erosion by brushing with anti-erosive toothpastes. J Dent 42:856–61. https://doi.org/10.1016/j.jdent.2014.03.011
doi: 10.1016/j.jdent.2014.03.011
pubmed: 24704085