Anti-Tick Vaccines: Current Advances and Future Prospects.
Anti-tick vaccine antigens
Anti-tick vaccines
Computational biology
Reverse vaccinology
Tick control
Journal
Methods in molecular biology (Clifton, N.J.)
ISSN: 1940-6029
Titre abrégé: Methods Mol Biol
Pays: United States
ID NLM: 9214969
Informations de publication
Date de publication:
2022
2022
Historique:
entrez:
24
11
2021
pubmed:
25
11
2021
medline:
21
1
2022
Statut:
ppublish
Résumé
Ticks are increasingly a global public health and veterinary concern. They transmit numerous pathogens that are of veterinary and public health importance. Acaricides, livestock breeding for tick resistance, tick handpicking, pasture spelling, and anti-tick vaccines (ATVs) are in use for the control of ticks and tick-borne diseases (TTBDs); acaricides and ATVs being the most and least used TTBD control methods respectively. The overuse and misuse of acaricides has inadvertently selected for tick strains that are resistant to acaricides. Furthermore, vaccines are rare and not commercially available in sub-Saharan Africa (SSA). It doesn't help that many of the other methods are labor-intensive and found impractical especially for larger farm operations. The success of TTBD control is therefore dependent on integrating all the currently available methods. Vaccines have been shown to be cheap and effective. However, their large-scale deployment for TTBD control in SSA is hindered by commercial unavailability of efficacious anti-tick vaccines against sub-Saharan African tick strains. Thanks to advances in genomics, transcriptomics, and proteomics technologies, many promising anti-tick vaccine antigens (ATVA) have been identified. However, few of them have been investigated for their potential as ATV candidates. Reverse vaccinology (RV) can be leveraged to accelerate ATV discovery. It is cheap and shortens the lead time from ATVA discovery to vaccine production. This chapter provides a brief overview of recent advances in ATV development, ATVs, ATV effector mechanisms, and anti-tick RV. Additionally, it provides a detailed outline of vaccine antigen selection and analysis using computational methods.
Identifiants
pubmed: 34816410
doi: 10.1007/978-1-0716-1888-2_15
doi:
Substances chimiques
Acaricides
0
Antigens
0
Vaccines
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
253-267Informations de copyright
© 2022. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.
Références
Wikel SK (2018) Ticks and tick-borne infections: complex ecology, agents, and host interactions. Vet Sci 5:1–22
Lynen G, Zeman P, Bakuname C, Di Giulio G, Mtui P, Sanka P, Jongejan F (2008) Shifts in the distributional ranges of Boophilus ticks in Tanzania: evidence that a parapatric boundary between Boophilus microplus and B. decoloratus follows climate gradients. Exp Appl Acarol 44:147–164
pubmed: 18266058
Randolph SE (2010) To what extent has climate change contributed to the recent epidemiology of tick-borne diseases? Vet Parasitol 167:92–94
pubmed: 19833440
Jongejan F, Uilenberg G (2004) The global importance of ticks. Parasitology 129:S3–S14
pubmed: 15938502
Sambri V, Marangoni A, Storni E, Cavrini F, Moroni A, Sparacino M, Cevenini R (2004) Infezioni zoonosiche trasmesse da zecche: Aspetti clinici e diagnostici in medicina umana. Parassitologia 46:109–113
pubmed: 15305697
Telmadarraiy Z, Chinikar S, Vatandoost H, Faghihi F, Hosseini-Chegeni A (2015) Vectors of Crimean Congo hemorrhagic fever virus in Iran. J Arthropod Borne Dis 9:137–147
pubmed: 26623426
pmcid: 4662786
Manjunathachar HV, Saravanan BC, Kesavan M, Karthik K, Rathod P, Gopi M, Tamilmahan P, Balaraju BL (2014) Economic importance of ticks and their effective control strategies. Asian Pac. J. Trop. Dis. 4:S770–S779
Nuzzo JB, Meyer D, Snyder M, Ravi SJ, Lapascu A, Souleles J, Andrada CI, Bishai D (2019) What makes health systems resilient against infectious disease outbreaks and natural hazards? Results from a scoping review. BMC Public Health 19:1310
pubmed: 31623594
pmcid: 6798426
Chizyuka HG, Mulilo JB (1990) Methods currently used for the control of multi-host ticks: their validity and proposals for future control strategies. Parassitologia 32:127–132
pubmed: 2284125
Jongejan F, Uilenberg G (1994) Ticks and control methods. Rev Sci Tech 13:1201–1226
pubmed: 7711310
Kocan KM, de la Fuente J, Blouin EF, Coetzee JF, Ewing SA (2010) The natural history of Anaplasma marginale. Vet Parasitol 167:95–107
pubmed: 19811876
Ghosh S, Azhahianambi P, Yadav MP (2007) Upcoming and future strategies of tick control: a review S. J Vector Borne Dis 44:79–89
pubmed: 17722860
Dela FJ, Rodríguez M, JC G-GARÍ (2000) Immunological control of ticks through vaccination with Boophilus microplus gut antigens. Ann N Y Acad Sci 916:617–621
De La Fuente J, Rodríguez M, Montero C et al (1999) Vaccination against ticks (Boophilus spp.): the experience with the Bm86-based vaccine Gavac((TM)). Genet Anal 15:143–148
pubmed: 10596754
Canales M, Almazán C, Naranjo V, Jongejan F, de la Fuente J (2009) Vaccination with recombinant Boophilus annulatus Bm86 ortholog protein, Ba86, protects cattle against B. annulatus and B. microplus infestations. BMC Biotechnol 9:29
pubmed: 19335900
pmcid: 2667501
De la Fuente J, Merino O (2013) Vaccinomics, the new road to tick vaccines. Vaccine 31:5923–5929
pubmed: 24396872
Valle MR, Guerrero FD (2018) Anti-tick vaccines in the omics era. Front Biosci 10:122–136
De la Fuente J, Almazán C, Canales M, Pérez de la Lastra JM, Kocan KM, Willadsen P (2007) A ten-year review of commercial vaccine performance for control of tick infestations on cattle. Anim Health Res Rev 8:23–28
pubmed: 17692140
Rego ROM, Trentelman JJA, Anguita J et al (2019) Counterattacking the tick bite: towards a rational design of anti-tick vaccines targeting pathogen transmission. Parasit Vectors 12:229
pubmed: 31088506
pmcid: 6518728
Rodríguez-Mallon A (2016) Developing anti-tick vaccines. In: Methods Mol. Biol. Humana Press Inc., Totowa, New Jersey, pp 243–259
Lew-Tabor AE, Rodriguez Valle M (2016) A review of reverse vaccinology approaches for the development of vaccines against ticks and tick borne diseases. Ticks Tick Borne Dis 7:573–585
pubmed: 26723274
de la Fuente J, Kopáček P, Lew-Tabor A, Maritz-Olivier C (2016) Strategies for new and improved vaccines against ticks and tick-borne diseases. Parasite Immunol 38:754–769
pubmed: 27203187
Hardy S, Legagneux V, Audic Y, Paillard L (2010) Reverse genetics in eukaryotes. Biol Cell 102:561–580
pubmed: 20812916
pmcid: 3017359
Willadsen P, Kemp DH (1988) Vaccination with “concealed” antigens for tick control. Parasitol Today 4:196–198
pubmed: 15463090
Allen JR, Humphreys SJ (1979) Immunisation of Guinea pigs and cattle against ticks [13]. Nature 280:491–493
pubmed: 460427
De La Fuente J, Contreras M (2015) Tick vaccines: current status and future directions. Expert Rev Vaccines 14:1367–1376
pubmed: 26289976
Guerrero FD, Miller RJ, Pérez de León AA (2012) Cattle tick vaccines: many candidate antigens, but will a commercially viable product emerge? Int J Parasitol 42:421–427
pubmed: 22549026
Schetters T, Bishop R, Crampton M et al (2016) Cattle tick vaccine researchers join forces in CATVAC. Parasit Vectors 9:105
pubmed: 26911668
pmcid: 4766707
Bhowmick B, Han Q (2020) Understanding tick biology and its implications in anti-tick and transmission blocking vaccines against tick-borne pathogens. Front Vet Sci 7:319
pubmed: 32582785
pmcid: 7297041
Tsuda A, Mulenga A, Sugimoto C, Nakajima M, Ohashi K, Onuma M (2001) cDNA cloning, characterization and vaccine effect analysis of Haemaphysalis longicornis tick saliva proteins. Vaccine 19:4287–4296
pubmed: 11457556
Mulenga A, Sugimoto C, Sako Y, Ohashi K, Musoke A, Shubash M, Onuma M (1999) Molecular characterization of a Haemaphysalis longicornis tick salivary gland-associated 29-kilodalton protein and its effect as a vaccine against tick infestation in rabbits. Infect Immun 67:1652–1658
pubmed: 10084999
pmcid: 96509
Trimnell AR, Hails RS, Nuttall PA (2002) Dual action ectoparasite vaccine targeting “exposed” and “concealed” antigens. Vaccine 20:3560–3568
pubmed: 12297402
Campbell EM, Burdin M, Hoppler S, Bowman AS (2010) Role of an aquaporin in the sheep tick Ixodes ricinus: assessment as a potential control target. Int J Parasitol 40:15–23
pubmed: 19635481
Guerrero FD, Andreotti R, Bendele KG, Cunha RC, Miller RJ, Yeater K, De León AAP (2014) Rhipicephalus (Boophilus) microplus aquaporin as an effective vaccine antigen to protect against cattle tick infestations. Parasit Vectors 7:475
pubmed: 25306139
pmcid: 4200143
Ndekezi C, Nkamwesiga J, Ochwo S, Kimuda MP, Mwiine FN, Tweyongyere R, Amanyire W, Muhanguzi D (2019) Identification of ixodid tick-specific aquaporin-1 potential anti-tick vaccine epitopes: an in-silico analysis. Front Bioeng Biotechnol 7:236
pubmed: 31612130
pmcid: 6775757
Hajdusek O, Sojka D, Kopacek P, Buresova V, Franta Z, Sauman I, Winzerling J, Grubhoffer L (2009) Knockdown of proteins involved in iron metabolism limits tick reproduction and development. Proc Natl Acad Sci U S A 106:1033–1038
pubmed: 19171899
pmcid: 2633537
Hajdusek O, Almazán C, Loosova G, Villar M, Canales M, Grubhoffer L, Kopacek P, de la Fuente J (2010) Characterization of ferritin 2 for the control of tick infestations. Vaccine 28:2993–2998
pubmed: 20171306
Parizi LF, Utiumi KU, Imamura S, Onuma M, Ohashi K, Masuda A, da Silva VI (2011) Cross immunity with Haemaphysalis longicornis glutathione S-transferase reduces an experimental Rhipicephalus (Boophilus) microplus infestation. Exp Parasitol 127:113–118
pubmed: 20619263
Da Silva VI, Logullo C, Sorgine M, Velloso FF, Rosa De Lima MF, Gonzales JC, Masuda H, Oliveira PL, Masuda A (1998) Immunization of bovines with an aspartic proteinase precursor isolated from Boophilus microplus eggs. Vet Immunol Immunopathol 66:331–341
Leal AT, Seixas A, Pohl PC, Ferreira CAS, Logullo C, Oliveira PL, Farias SE, Termignoni C, da Silva VI, Masuda A (2006) Vaccination of bovines with recombinant Boophilus yolk pro-Cathepsin. Vet Immunol Immunopathol 114:341–345
pubmed: 16997384
Seixas A, Oliveira P, Termignoni C, Logullo C, Masuda A, da Silva VI (2012) Rhipicephalus (Boophilus) microplus embryo proteins as target for tick vaccine. Vet Immunol Immunopathol 148:149–156
pubmed: 21620488
Seixas A, Leal AT, Nascimento-Silva MCL, Masuda A, Termignoni C, da Silva VI (2008) Vaccine potential of a tick vitellin-degrading enzyme (VTDCE). Vet Immunol Immunopathol 124:332–340
pubmed: 18490061
Parizi LF, Reck J, Oldiges DP, Guizzo MG, Seixas A, Logullo C, de Oliveira PL, Termignoni C, Martins JR, da Silva VI (2012) Multi-antigenic vaccine against the cattle tick Rhipicephalus (Boophilus) microplus: a field evaluation. Vaccine 30:6912–6917
pubmed: 22981764
Elvin CM, Kemp DH (1994) Generic approaches to obtaining efficacious antigens from vector arthropods. Int J Parasitol 24:67–79
pubmed: 8021109
Wikel SK (1996) Host immunity to ticks. Annu Rev Entomol 41:1–22
pubmed: 8546443
Sette A, Rappuoli R (2010) Reverse vaccinology: developing vaccines in the era of genomics. Immunity 33:530–541
pubmed: 21029963
pmcid: 3320742
Ullmann AJ, Lima CMR, Guerrero FD, Piesman J, Black WC IV (2005) Genome size and organization in the blacklegged tick, Ixodes scapularis and the southern cattle tick, Boophilus microplus. Insect Mol Biol 14:217–222
pubmed: 15796755
Gulia-Nuss M, Nuss AB, Meyer JM et al (2016) Genomic insights into the Ixodes scapularis tick vector of Lyme disease. Nat Commun 7:10507
pubmed: 26856261
pmcid: 4748124
Perner J, Kropáčková S, Kopáček P, Ribeiro JMC (2018) Sialome diversity of ticks revealed by RNAseq of single tick salivary glands. PLoS Negl Trop Dis 12:e0006410
pubmed: 29652888
pmcid: 5919021
Anderson JM, Sonenshine DE, Valenzuela JG (2008) Exploring the mialome of ticks: an annotated catalogue of midgut transcripts from the hard tick, Dermacentor variabilis (Acari: Ixodidae). BMC Genomics 9:552
pubmed: 19021911
pmcid: 2644717
Yu CS, Chen YC, Lu CH, Hwang JK (2006) Prediction of protein subcellular localization. Proteins Struct Funct Genet 64:643–651
pubmed: 16752418
Yu CS, Cheng CW, Su WC, Chang KC, Huang SW, Hwang JK, Lu CH (2014) CELLO2GO: a web server for protein subCELlular lOcalization prediction with functional gene ontology annotation. PLoS One 9:e99368
pubmed: 24911789
pmcid: 4049835
Edgar RC (2004) MUSCLE: a multiple sequence alignment method with reduced time and space complexity. BMC Bioinformatics 5:113
pubmed: 15318951
pmcid: 517706
Shafee T, Cooke I (2016) AlignStat: a web-tool and R package for statistical comparison of alternative multiple sequence alignments. BMC Bioinformatics 17:434
pubmed: 27784265
pmcid: 5081975
Bailey TL, Boden M, Buske FA, Frith M, Grant CE, Clementi L, Ren J, Li WW, Noble WS (2009) MEME S UITE : tools for motif discovery and searching. Nucleic Acids Res 37:202–208
Chowell D, Krishna S, Becker PD, Cocita C, Shu J, Tan X, Greenberg PD, Klavinskis LS, Blattman JN, Anderson KS (2015) TCR contact residue hydrophobicity is a hallmark of immunogenic CD8+ T cell epitopes. Proc Natl Acad Sci U S A 112:E1754–E1762
pubmed: 25831525
pmcid: 4394253
Singh H, Raghava GPS (2002) ProPred: prediction of HLA-DR binding sites. Bioinformatics 17:1236–1237
Kringelum JV, Lundegaard C, Lund O, Nielsen M (2012) Reliable B cell epitope predictions: impacts of method development and improved benchmarking. PLoS Comput Biol 8:e1002829
pubmed: 23300419
pmcid: 3531324
Jespersen MC, Peters B, Nielsen M, Marcatili P (2017) BepiPred-2.0: improving sequence-based B-cell epitope prediction using conformational epitopes. Nucleic Acids Res 45:W24–W29
pubmed: 28472356
pmcid: 5570230