Weight changes, metabolic syndrome and all-cause mortality among Asian adults living with HIV.
Asian people living with HIV
HIV/AIDS
all-cause mortality
metabolic syndrome
weight gain
Journal
HIV medicine
ISSN: 1468-1293
Titre abrégé: HIV Med
Pays: England
ID NLM: 100897392
Informations de publication
Date de publication:
03 2022
03 2022
Historique:
received:
14
07
2021
accepted:
09
11
2021
pubmed:
25
11
2021
medline:
15
3
2022
entrez:
24
11
2021
Statut:
ppublish
Résumé
We investigated weight changes following antiretroviral therapy (ART) initiation, the development of metabolic syndrome (MetS) and its association with all-cause mortality among Asian adults living with HIV. Participants enrolled in a regional Asian HIV-infected cohort with weight and height measurements at ART initiation were eligible for inclusion in the analysis. Factors associated with weight changes and incident MetS (according to the International Diabetic Federation (IDF) definition) were analysed using linear mixed models and Cox regression, respectively. Competing-risk regression models were used to investigate the association of MetS with all-cause mortality. Among 4931 people living with HIV (PLWH), 66% were male. At ART initiation, the median age was 34 [interquartile range (IQR) 29-41] years, and the median (IQR) weight and body mass index (BMI) were 55 (48-63) kg and 20.5 (18.4-22.9) kg/m Weight gain after ART initiation was significantly higher among those initiating ART with lower CD4 count, higher HIV RNA and an INSTI-based regimen after controlling for baseline BMI. Greater efforts to identify and manage MetS among PLWH are needed.
Identifiants
pubmed: 34816562
doi: 10.1111/hiv.13211
pmc: PMC8847330
mid: NIHMS1755784
doi:
Substances chimiques
Reverse Transcriptase Inhibitors
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
274-286Subventions
Organisme : NIAID NIH HHS
ID : U01 AI069907
Pays : United States
Investigateurs
P S Ly
(PS)
V Khol
(V)
F J Zhang
(FJ)
H X Zhao
(HX)
N Han
(N)
M P Lee
(MP)
P C K Li
(PCK)
T S Kwong
(TS)
T H Li
(TH)
N Kumarasamy
(N)
C Ezhilarasi
(C)
S Pujari
(S)
K Joshi
(K)
S Gaikwad
(S)
A Chitalikar
(A)
S Sangle
(S)
V Mave
(V)
I Marbaniang
(I)
S Nimkar
(S)
T P Merati
(TP)
D N Wirawan
(DN)
F Yuliana
(F)
E Yunihastuti
(E)
A Widhani
(A)
S Maria
(S)
T H Karjadi
(TH)
J Tanuma
(J)
S Oka
(S)
T Nishijima
(T)
J Y Choi
(JY)
S Na
(S)
J M Kim
(JM)
Y M Gani
(YM)
N B Rudi
(NB)
I Azwa
(I)
A Kamarulzaman
(A)
S F SyedOmar
(SF)
S Ponnampalavanar
(S)
R Ditangco
(R)
M K Pasayan
(MK)
M L Mationg
(ML)
Y J Chan
(YJ)
W W Ku
(WW)
P C Wu
(PC)
E Ke
(E)
O T Ng
(OT)
P L Lim
(PL)
L S Lee
(LS)
T Yap
(T)
O T Ng
(OT)
A Avihingsanon
(A)
S Gatechompol
(S)
P Phanuphak
(P)
C Phadungphon
(C)
S Kiertiburanakul
(S)
A Phuphuakrat
(A)
L Chumla
(L)
N Sanmeema
(N)
R Chaiwarith
(R)
T Sirisanthana
(T)
J Praparattanapan
(J)
K Nuket
(K)
S Khusuwan
(S)
P Payoong
(P)
P Kantipong
(P)
P Kambua
(P)
T N Pham
(TN)
K V Nguyen
(KV)
D T H Nguyen
(DTH)
D T Nguyen
(DT)
C D Do
(CD)
A V Ngo
(AV)
L T Nguyen
(LT)
A H Sohn
(AH)
J L Ross
(JL)
B Petersen
(B)
M G Law
(MG)
A Jiamsakul
(A)
D Rupasinghe
(D)
Informations de copyright
© 2021 British HIV Association.
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