Targeting arterial partial pressure of carbon dioxide in acute respiratory distress syndrome patients using extracorporeal carbon dioxide removal.
ECCO2R
acid-base
acute kidney injury
acute respiratory distress syndrome
arterial partial pressure of carbon dioxide
carbon dioxide
continuous venovenous hemofiltration
mathematical model
Journal
Artificial organs
ISSN: 1525-1594
Titre abrégé: Artif Organs
Pays: United States
ID NLM: 7802778
Informations de publication
Date de publication:
Apr 2022
Apr 2022
Historique:
revised:
06
10
2021
received:
17
08
2021
accepted:
08
11
2021
pubmed:
25
11
2021
medline:
5
4
2022
entrez:
24
11
2021
Statut:
ppublish
Résumé
A retrospective analysis of SUPERNOVA trial data showed that reductions in tidal volume to ultraprotective levels without significant increases in arterial partial pressure of carbon dioxide (PaCO We used a whole-body mathematical model of acid-base balance to quantify the effect of altering carbon dioxide (CO After calibrating model parameters to the clinical study data using the PrismaLung device, model predictions determined optimal extracorporeal blood flow rates for the PrismaLung+ and mechanical ventilation frequencies to obtain target PaCO The described model provides guidance on achieving target PaCO
Sections du résumé
BACKGROUND
BACKGROUND
A retrospective analysis of SUPERNOVA trial data showed that reductions in tidal volume to ultraprotective levels without significant increases in arterial partial pressure of carbon dioxide (PaCO
METHODS
METHODS
We used a whole-body mathematical model of acid-base balance to quantify the effect of altering carbon dioxide (CO
RESULTS
RESULTS
After calibrating model parameters to the clinical study data using the PrismaLung device, model predictions determined optimal extracorporeal blood flow rates for the PrismaLung+ and mechanical ventilation frequencies to obtain target PaCO
CONCLUSIONS
CONCLUSIONS
The described model provides guidance on achieving target PaCO
Substances chimiques
Carbon Dioxide
142M471B3J
Types de publication
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
677-687Subventions
Organisme : Narodowe Centrum Nauki
ID : 2017/27/B/ST7/03029
Organisme : Baxter International
Informations de copyright
© 2021 International Center for Artificial Organs and Transplantation and Wiley Periodicals LLC.
Références
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