Frank's sign and paired ear creases of the helix : Current concepts of significance for morbidity.
Atherosclerosis
Cardiovascular disease
Cerebrovascular disease
Frank’s sign
Histology
Paired ear creases of the helix
Journal
Wiener klinische Wochenschrift
ISSN: 1613-7671
Titre abrégé: Wien Klin Wochenschr
Pays: Austria
ID NLM: 21620870R
Informations de publication
Date de publication:
Mar 2022
Mar 2022
Historique:
received:
02
07
2021
accepted:
14
10
2021
pubmed:
25
11
2021
medline:
17
3
2022
entrez:
24
11
2021
Statut:
ppublish
Résumé
Frank's sign (FS) was described in 1973 as an auricular marker for cardiovascular disease presenting as a crease of the auricular lobule. Since its first clinical description, there have been multiple studies underlining the role of FS in a myriad of conditions, such as atherosclerosis, hypertension, cerebrovascular disease, peripheral artery disease, metabolic diseases as well as studies looking at physiological differences in the auricular shape that may mimic FS; however, a complex study to comprehensively analyze the clinical, gross, and histological findings of patients with FS has not yet been performed. Most studies focused on a specific system, mechanism of disease entry. This short review tries to summarize the current knowledge of FS in relation to diseases as well as its clinical classification, histology, and association with the recently described paired ear creases of the helix, as an attempt to reveal the dubious role of FS as a possible prognostic and predictive marker.
Identifiants
pubmed: 34817665
doi: 10.1007/s00508-021-01969-x
pii: 10.1007/s00508-021-01969-x
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
237-242Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.
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