Chrysin and flunixin meglumine mitigate overloaded copper-induced testicular and spermatological damages via modulation of oxidative stress and apoptosis in rats.
apoptosis
chrysin
copper
flunixin meglumine
reproductive toxicity
Journal
Andrologia
ISSN: 1439-0272
Titre abrégé: Andrologia
Pays: Germany
ID NLM: 0423506
Informations de publication
Date de publication:
Mar 2022
Mar 2022
Historique:
revised:
12
10
2021
received:
21
07
2021
accepted:
13
11
2021
pubmed:
25
11
2021
medline:
16
2
2022
entrez:
24
11
2021
Statut:
ppublish
Résumé
This study aimed to evaluate the possible protective actions of chrysin and flunixine meglumine on testicular and spermatological injuries experimentally stimulated by copper. We separated 36 male Sprague-Dawley rats into six equal groups: control, chrysin, flunixine meglumine, copper, copper +chrysin and copper +flunixine meglumine. Chrysin (50 mg/kg/bw/po), flunixine meglumine (2.2 mg/kg/bw/ip) and copper (500 mg/kg/bw/po) were administered day to day for 21 days. Copper administration caused significant morphological, physiological and biochemical alterations compared to the control group, which are as follows: production of oxidative stress, thanks to rise in testis lipid peroxidation and fall in antioxidant enzyme concentrations, decrease in sperm quality and increase in morphologic sperm abnormalities, suppression of spermatogenesis and prominent alterations in the testis histomorphology and induction of apoptosis in the testis tissues. On the other hand, compared to the copper group, treatment with chrysin or flunixine meglumine significantly attenuated these alterations. In conclusion, chrysin and flunixine meglumine have benefits such as antioxidant, antiapoptotic and anti-inflammatory against copper-induced testicular and spermatological damages in rats via the modulation of oxidative stress and apoptosis. Consequently, chrysin is a natural product which has comparable therapeutic actions to flunixine meglumine on the male reproductive system.
Substances chimiques
Antioxidants
0
Flavonoids
0
chrysin
3CN01F5ZJ5
Copper
789U1901C5
flunixin meglumine
8Y3JK0JW3U
Clonixin
V7DXN0M42R
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e14327Subventions
Organisme : Firat University Scientific Research Projects Unit
ID : (VF.14.11)
Informations de copyright
© 2021 Wiley-VCH GmbH.
Références
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