Ligands binding to the prion protein induce its proteolytic release with therapeutic potential in neurodegenerative proteinopathies.


Journal

Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440

Informations de publication

Date de publication:
26 Nov 2021
Historique:
entrez: 24 11 2021
pubmed: 25 11 2021
medline: 25 11 2021
Statut: ppublish

Résumé

The prion protein (PrP

Identifiants

pubmed: 34818048
doi: 10.1126/sciadv.abj1826
pmc: PMC8612689
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

eabj1826

Références

Annu Rev Biochem. 2019 Jun 20;88:785-810
pubmed: 30917002
Prog Neurobiol. 2015 Dec;135:1-20
pubmed: 26522965
EMBO J. 1996 Mar 15;15(6):1255-64
pubmed: 8635458
J Biol Chem. 2020 Oct 9;295(41):14178-14188
pubmed: 32788217
Science. 2003 Oct 31;302(5646):814-8
pubmed: 14593165
Nature. 2001 Aug 16;412(6848):739-43
pubmed: 11507642
Microbiol Immunol. 2013 Apr;57(4):288-97
pubmed: 23586633
Neurobiol Dis. 2009 May;34(2):267-78
pubmed: 19385058
Proc Natl Acad Sci U S A. 2019 Apr 16;116(16):7793-7798
pubmed: 30936307
FEBS Lett. 2009 Nov 19;583(22):3671-5
pubmed: 19854187
J Biol Chem. 2005 Mar 25;280(12):11247-58
pubmed: 15618225
J Biol Chem. 2012 Sep 28;287(40):33104-8
pubmed: 22915585
J Immunol. 2001 Jul 1;167(1):123-31
pubmed: 11418640
J Biol Chem. 2018 May 25;293(21):8020-8031
pubmed: 29636413
Neurobiol Dis. 2009 Nov;36(2):233-41
pubmed: 19632330
Sci Rep. 2016 Mar 15;6:23180
pubmed: 26976106
Proc Natl Acad Sci U S A. 2001 Aug 14;98(17):9836-41
pubmed: 11504948
Biophys J. 2014 Nov 18;107(10):2313-24
pubmed: 25418300
Neurology. 2014 Nov 18;83(21):1930-5
pubmed: 25344383
PLoS Pathog. 2012;8(11):e1002985
pubmed: 23133383
Structure. 2014 Feb 4;22(2):291-303
pubmed: 24373770
Science. 2000 Feb 25;287(5457):1503-6
pubmed: 10688802
Annu Rev Biophys Biomol Struct. 1997;26:373-99
pubmed: 9241424
EMBO Mol Med. 2010 Aug;2(8):289-90
pubmed: 20698011
Mol Neurodegener. 2011 May 27;6:36
pubmed: 21619641
J Neurochem. 2020 Jan;152(1):136-150
pubmed: 31264722
J Appl Crystallogr. 2015 Mar 12;48(Pt 2):431-443
pubmed: 25844078
EMBO J. 2019 Feb 1;38(3):
pubmed: 30630857
Neurobiol Aging. 2014 Jul;35(7):1537-48
pubmed: 24602510
J Biol Chem. 2002 Jul 12;277(28):25457-64
pubmed: 11994310
Nat Commun. 2011 Jun 07;2:336
pubmed: 21654636
J Neurochem. 2009 Apr;109(1):60-73
pubmed: 19226372
Protein Sci. 2013 Jan;22(1):22-34
pubmed: 23081827
J Comput Chem. 2004 Oct;25(13):1605-12
pubmed: 15264254
PLoS One. 2017 Aug 7;12(8):e0182589
pubmed: 28787011
Proc Natl Acad Sci U S A. 2001 Jul 31;98(16):9295-9
pubmed: 11470893
J Biol Chem. 2010 Aug 20;285(34):26335-40
pubmed: 20554517
Nucleic Acids Res. 2020 Nov 4;48(19):10615-10631
pubmed: 32776089
J Appl Crystallogr. 2017 Jun 26;50(Pt 4):1212-1225
pubmed: 28808438
Science. 2003 Oct 31;302(5646):871-4
pubmed: 14593181
Nat Protoc. 2008;3(4):555-62
pubmed: 18388937
Nature. 2013 Sep 5;501(7465):102-6
pubmed: 23903654
J Biol Chem. 1993 Jul 25;268(21):15922-8
pubmed: 8101844
EMBO J. 2011 May 18;30(10):2057-70
pubmed: 21441896
J Biol Chem. 2013 Mar 15;288(11):7857-7866
pubmed: 23362282
BMJ. 2018 Oct 31;363:k4608
pubmed: 30381386
Neuron. 2010 Jun 10;66(5):739-54
pubmed: 20547131
J Neurosci. 2012 Sep 19;32(38):13255-63
pubmed: 22993441
Neuron. 2008 Aug 14;59(3):359-74
pubmed: 18701063
Glycobiology. 1993 Aug;3(4):319-29
pubmed: 7691278
Pathogens. 2018 Mar 07;7(1):
pubmed: 29518975
J Biol Chem. 2009 Aug 21;284(34):22590-600
pubmed: 19564338
J Biol Chem. 2019 Apr 12;294(15):6042-6053
pubmed: 30787106
J Biol Chem. 2016 Feb 12;291(7):3174-83
pubmed: 26719327
Nature. 1992 Apr 16;356(6370):577-82
pubmed: 1373228
Science. 2005 Jun 3;308(5727):1435-9
pubmed: 15933194
Nat Protoc. 2007;2(10):2480-91
pubmed: 17947990
Mol Med. 1994 Nov;1(1):19-30
pubmed: 8790598
Nature. 2003 Mar 6;422(6927):80-3
pubmed: 12621436
J Biol Chem. 2017 Oct 13;292(41):16858-16871
pubmed: 28842494
BMC Neurosci. 2010 Oct 14;11:130
pubmed: 20946660
Acta Neuropathol. 2020 Mar;139(3):503-526
pubmed: 31853635
Biochemistry. 1997 Feb 18;36(7):1581-97
pubmed: 9048542
J Biol Chem. 2012 Feb 10;287(7):5021-32
pubmed: 22184125
Cell. 1994 Jul 1;77(7):967-8
pubmed: 7912659
Neurobiol Aging. 2005 Aug-Sep;26(8):1177-82
pubmed: 15917101
Front Mol Neurosci. 2017 Mar 20;10:77
pubmed: 28373833
Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3922-7
pubmed: 10097139
J Biol Chem. 2020 Jul 24;295(30):10420-10433
pubmed: 32513872
Ann Clin Transl Neurol. 2019 Feb 27;6(3):554-574
pubmed: 30911579
J Biol Chem. 2014 Sep 12;289(37):25497-508
pubmed: 25074940
J Biol Chem. 2020 Sep 25;295(39):13516-13531
pubmed: 32723867
Elife. 2015 Feb 05;4:
pubmed: 25654651
Mol Cell Biol. 2015 Oct;35(19):3381-95
pubmed: 26217011
Mol Neurobiol. 2018 Oct;55(10):7758-7774
pubmed: 29460268
Mol Neurobiol. 2019 Mar;56(3):2073-2091
pubmed: 29987703
J Neurochem. 2005 Dec;95(5):1373-86
pubmed: 16313516
Science. 2001 Oct 5;294(5540):178-82
pubmed: 11546838
J Biol Chem. 2003 May 16;278(20):18524-31
pubmed: 12637572
J Biol Chem. 2019 Apr 26;294(17):7085-7097
pubmed: 30872401
J Biol Chem. 2015 Jul 10;290(28):17041-54
pubmed: 25925953
Proc Natl Acad Sci U S A. 2020 Nov 17;117(46):28625-28631
pubmed: 33139554
J Neurochem. 2012 Mar;120(6):853-68
pubmed: 22145935
Acta Neuropathol. 2001 Jan;101(1):49-56
pubmed: 11194941
Rev Sci Instrum. 2007 Jan;78(1):013705
pubmed: 17503926
Elife. 2017 May 20;6:
pubmed: 28527237
Neurobiol Dis. 2016 Jul;91:124-131
pubmed: 26949218
Nat Neurosci. 2017 Nov;20(11):1569-1579
pubmed: 28945221
J Neurochem. 2004 Apr;89(2):454-63
pubmed: 15056288
Biophys J. 2015 Aug 18;109(4):793-805
pubmed: 26287631
Science. 2004 Mar 5;303(5663):1514-6
pubmed: 14752167
Lab Invest. 2019 Nov;99(11):1741-1748
pubmed: 31249376
J Gen Virol. 2008 Jun;89(Pt 6):1533-1544
pubmed: 18474571
Brain Pathol. 2021 Sep;31(5):e12941
pubmed: 33624334
Mol Neurobiol. 2020 Jun;57(6):2812-2829
pubmed: 32367491
J Neurochem. 2017 Jul;142(1):171-182
pubmed: 28407243
Neuron. 2013 Sep 4;79(5):887-902
pubmed: 24012003
Hum Mol Genet. 2002 Oct 1;11(21):2615-24
pubmed: 12354787
Acta Neuropathol. 2020 Mar;139(3):527-546
pubmed: 31673874
Bioinformatics. 2016 Jul 1;32(13):2062-4
pubmed: 27153695
Antimicrob Agents Chemother. 2018 Jan 25;62(2):
pubmed: 29133563
J Cell Sci. 2016 Oct 15;129(20):3878-3891
pubmed: 27591261
Trends Cell Biol. 1994 Jan;4(1):10-4
pubmed: 14731823
J Neurosci. 2011 May 18;31(20):7259-63
pubmed: 21593310
J Med Chem. 2003 Aug 14;46(17):3563-4
pubmed: 12904059
PLoS One. 2008;3(12):e3872
pubmed: 19060956
Nature. 2016 Aug 25;536(7617):464-8
pubmed: 27501152
PLoS Pathog. 2018 Oct 1;14(10):e1007335
pubmed: 30273408
J Neurosci. 2014 Apr 30;34(18):6140-5
pubmed: 24790184
Cell. 2003 Apr 4;113(1):49-60
pubmed: 12679034
Nat Commun. 2014 Mar 04;5:3374
pubmed: 24594908
Nature. 2009 Feb 26;457(7233):1128-32
pubmed: 19242475
EMBO Mol Med. 2010 Aug;2(8):306-14
pubmed: 20665634
Sci Rep. 2013 Oct 09;3:2911
pubmed: 24105336
PLoS Pathog. 2015 Feb 24;11(2):e1004662
pubmed: 25710374
Nature. 2011 Feb 24;470(7335):540-2
pubmed: 21350487
EMBO J. 2019 Aug 1;38(15):e101183
pubmed: 31267565
J Neurosci. 2018 Dec 12;38(50):10595-10606
pubmed: 30355631
J Neurochem. 2016 Apr;137(1):88-100
pubmed: 26710111
Proc Natl Acad Sci U S A. 2008 Jul 22;105(29):10238-43
pubmed: 18632556
JCI Insight. 2019 Jul 30;5:
pubmed: 31361599
Eur J Neurosci. 2006 May;23(10):2635-47
pubmed: 16817866
Mol Neurodegener. 2018 Apr 6;13(1):18
pubmed: 29625583
Brain. 2016 Feb;139(Pt 2):526-46
pubmed: 26667279
Science. 1982 Apr 9;216(4542):136-44
pubmed: 6801762
J Immunol. 2017 Jul 1;199(1):224-232
pubmed: 28533442
Trends Neurosci. 2002 Dec;25(12):616-20
pubmed: 12446128
Commun Biol. 2020 Jul 9;3(1):365
pubmed: 32647130
J Virol. 2005 Jul;79(13):8330-8
pubmed: 15956578
Mol Immunol. 2009 Feb;46(4):532-40
pubmed: 18973947
J Appl Crystallogr. 2012 Mar 15;45(Pt 2):342-350
pubmed: 25484842
Protein Expr Purif. 2005 May;41(1):207-34
pubmed: 15915565
Int J Mol Sci. 2019 Jan 16;20(2):
pubmed: 30654447
Acta Neuropathol. 2020 Dec;140(6):811-830
pubmed: 32926214

Auteurs

Luise Linsenmeier (L)

Institute of Neuropathology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.

Behnam Mohammadi (B)

Institute of Neuropathology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.

Mohsin Shafiq (M)

Institute of Neuropathology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.

Karl Frontzek (K)

Institute of Neuropathology, University of Zurich, Zürich, Switzerland.

Julia Bär (J)

Institute of Biology, Humboldt-Universität zu Berlin, Berlin, Germany.
Center for Molecular Neurobiology Hamburg (ZMNH), UKE, Hamburg, Germany.

Amulya N Shrivastava (AN)

École Normale Supérieure, Institut de Biologie de l'ENS (IBENS), INSERM, CNRS, PSL Research University, Paris, France.

Markus Damme (M)

Institute of Biochemistry, Christian Albrechts University, Kiel, Germany.

Feizhi Song (F)

Institute of Neuropathology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.

Alexander Schwarz (A)

Institute of Nanostructure and Solid State Physics, Universität Hamburg, Hamburg, Germany.

Stefano Da Vela (S)

European Molecular Biology Laboratory (EMBL), Hamburg, Germany.

Tania Massignan (T)

Dulbecco Telethon Laboratory of Prions and Amyloids, CIBIO, University of Trento, Trento, Italy.

Sebastian Jung (S)

Department Biochemistry of Neurodegenerative Diseases, Institute of Biochemistry and Pathobiochemistry, Ruhr University Bochum, Bochum, Germany.

Angela Correia (A)

Department of Neurology, University Medical Center Göttingen, Göttingen, Germany.

Matthias Schmitz (M)

Department of Neurology, University Medical Center Göttingen, Göttingen, Germany.

Berta Puig (B)

Department of Neurology, Experimental Research in Stroke and Inflammation, UKE, Hamburg, Germany.

Simone Hornemann (S)

Institute of Neuropathology, University of Zurich, Zürich, Switzerland.

Inga Zerr (I)

Department of Neurology, University Medical Center Göttingen, Göttingen, Germany.

Jörg Tatzelt (J)

Department Biochemistry of Neurodegenerative Diseases, Institute of Biochemistry and Pathobiochemistry, Ruhr University Bochum, Bochum, Germany.
Cluster of Excellence RESOLV, Bochum, Germany.

Emiliano Biasini (E)

Dulbecco Telethon Laboratory of Prions and Amyloids, CIBIO, University of Trento, Trento, Italy.

Paul Saftig (P)

Institute of Biochemistry, Christian Albrechts University, Kiel, Germany.

Michaela Schweizer (M)

Center for Molecular Neurobiology Hamburg (ZMNH), UKE, Hamburg, Germany.

Dmitri Svergun (D)

European Molecular Biology Laboratory (EMBL), Hamburg, Germany.

Ladan Amin (L)

Department of Biochemistry, Boston University School of Medicine, Boston, MA, USA.

Federica Mazzola (F)

Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland.

Luca Varani (L)

Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland.

Simrika Thapa (S)

Calgary Prion Research Unit, University of Calgary, Calgary, Alberta, Canada.

Sabine Gilch (S)

Calgary Prion Research Unit, University of Calgary, Calgary, Alberta, Canada.

Hermann Schätzl (H)

Calgary Prion Research Unit, University of Calgary, Calgary, Alberta, Canada.

David A Harris (DA)

Department of Biochemistry, Boston University School of Medicine, Boston, MA, USA.

Antoine Triller (A)

École Normale Supérieure, Institut de Biologie de l'ENS (IBENS), INSERM, CNRS, PSL Research University, Paris, France.

Marina Mikhaylova (M)

Institute of Biology, Humboldt-Universität zu Berlin, Berlin, Germany.
Center for Molecular Neurobiology Hamburg (ZMNH), UKE, Hamburg, Germany.

Adriano Aguzzi (A)

Institute of Neuropathology, University of Zurich, Zürich, Switzerland.

Hermann C Altmeppen (HC)

Institute of Neuropathology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.

Markus Glatzel (M)

Institute of Neuropathology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.

Classifications MeSH