MiR-191-5p alleviates microglial cell injury by targeting Map3k12 (mitogen-activated protein kinase kinase kinase 12) to inhibit the MAPK (mitogen-activated protein kinase) signaling pathway in Alzheimer's disease.
Alzheimer Disease
/ enzymology
Amyloid beta-Peptides
/ toxicity
Animals
Down-Regulation
/ genetics
Hippocampus
/ metabolism
MAP Kinase Kinase Kinases
/ metabolism
MAP Kinase Signaling System
/ drug effects
Male
Mice, Inbred C57BL
Mice, Transgenic
Microglia
/ drug effects
Peptide Fragments
/ toxicity
Alzheimer’s disease
Map3k12
Mapk signaling
miR-191-5p
microglia
Journal
Bioengineered
ISSN: 2165-5987
Titre abrégé: Bioengineered
Pays: United States
ID NLM: 101581063
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
pubmed:
26
11
2021
medline:
16
2
2022
entrez:
25
11
2021
Statut:
ppublish
Résumé
Alzheimer's disease (AD) is a progressive neurodegenerative disease. Multiple reports have elucidated that microRNAs are promising biomarkers for AD diagnosis and treatment. Herein, the effect of miR-191-5p on microglial cell injury and the underlying mechanism were explored. APP/PS1 transgenic mice were utilized to establish mouse model of AD. Amyloid-β protein 1-42 (Aβ1-42)-treated microglia were applied to establish
Identifiants
pubmed: 34818971
doi: 10.1080/21655979.2021.2008638
pmc: PMC8810200
doi:
Substances chimiques
Amyloid beta-Peptides
0
Peptide Fragments
0
amyloid beta-protein (1-42)
0
MAP Kinase Kinase Kinases
EC 2.7.11.25
mitogen-activated protein kinase kinase kinase 12
EC 2.7.11.25
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
12678-12690Références
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