Home-based pulmonary rehabilitation early after hospitalisation in COPD (early HomeBase): protocol for a randomised controlled trial.
COPD exacerbations
exercise
pulmonary rehabilitation
Journal
BMJ open respiratory research
ISSN: 2052-4439
Titre abrégé: BMJ Open Respir Res
Pays: England
ID NLM: 101638061
Informations de publication
Date de publication:
11 2021
11 2021
Historique:
received:
14
09
2021
accepted:
05
11
2021
entrez:
25
11
2021
pubmed:
26
11
2021
medline:
31
12
2021
Statut:
ppublish
Résumé
Chronic obstructive pulmonary disease (COPD) is characterised by exacerbations of respiratory disease, frequently requiring hospital admission. Pulmonary rehabilitation can reduce the likelihood of future hospitalisation, but programme uptake is poor. This study aims to compare hospital readmission rates, clinical outcomes and costs between people with COPD who undertake a home-based programme of pulmonary rehabilitation commenced early (within 2 weeks) of hospital discharge with usual care. A multisite randomised controlled trial, powered for superiority, will be conducted in Australia. Eligible patients admitted to one of the participating sites for an exacerbation of COPD will be invited to participate. Participants will be randomised 1:1. Intervention group participants will undertake an 8-week programme of home-based pulmonary rehabilitation commencing within 2 weeks of hospital discharge. Control group participants will receive usual care and a weekly phone call for attention control. Outcomes will be measured by a blinded assessor at baseline, after the intervention (week 9-10 posthospital discharge), and at 12 months follow-up. The primary outcome is hospital readmission at 12 months follow-up. Human Research Ethics approval for all sites provided by Alfred Health (Project 51216). Findings will be published in peer-reviewed journals, conferences and lay publications. ACTRN12619001122145.
Identifiants
pubmed: 34819323
pii: 8/1/e001107
doi: 10.1136/bmjresp-2021-001107
pmc: PMC8614151
pii:
doi:
Types de publication
Clinical Trial Protocol
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: NSC and AEH: declare grant funding from the NHMRC paid to their institution for the conduct of the trial. CFM declares board roles as Chair COPD National Program, Lung Foundation Australia; and Medical Director Institute for Breathing and Sleep. For all other authors, no competing interests are declared.
Références
Thorax. 2014 Nov;69(11):973-5
pubmed: 24985493
BMJ. 2004 Nov 20;329(7476):1209
pubmed: 15504763
Am Rev Respir Dis. 1987 Jun;135(6):1229-33
pubmed: 3592398
Ann Am Thorac Soc. 2021 May;18(5):e12-e29
pubmed: 33929307
Thorax. 2005 Nov;60(11):925-31
pubmed: 16055622
Respir Med. 2007 Feb;101(2):286-93
pubmed: 16806873
Chron Respir Dis. 2019 Jan-Dec;16:1479973119872517
pubmed: 31505942
Am J Respir Crit Care Med. 2015 Dec 1;192(11):1373-86
pubmed: 26623686
Eur Respir J. 2008 Feb;31(2):416-69
pubmed: 18238951
Chest. 2011 Dec;140(6):1534-1539
pubmed: 21737490
JAMA. 2021 Jul 20;326(3):257-265
pubmed: 34152382
Respirology. 2014 Jan;19(1):30-7
pubmed: 24256219
Lancet Respir Med. 2020 Jun;8(6):585-596
pubmed: 32526187
Curr Opin Pulm Med. 2018 Mar;24(2):138-146
pubmed: 29210750
Scand J Caring Sci. 2014 Jun;28(2):413-20
pubmed: 23713548
Med J Aust. 2017 Nov 20;207(10):436-442
pubmed: 29129177
Cochrane Database Syst Rev. 2016 Dec 08;12:CD005305
pubmed: 27930803
Eur Respir J. 2018 Jul 19;52(1):
pubmed: 30002103
Chron Respir Dis. 2018 Aug;15(3):323-326
pubmed: 29471678
Respirology. 2011 May;16(4):617-24
pubmed: 21199163
CMAJ. 2005 Aug 30;173(5):489-95
pubmed: 16129869
ERJ Open Res. 2020 Feb 17;6(1):
pubmed: 32083113
BMC Med. 2010 Mar 24;8:18
pubmed: 20334633
J Physiother. 2011;57(3):183-90
pubmed: 21843834
Chron Respir Dis. 2020 Jan-Dec;17:1479973120949207
pubmed: 32815732
PLoS One. 2016 May 05;11(5):e0109913
pubmed: 27149674
Respirology. 2009 Mar;14(2):230-8
pubmed: 19272084
Thorax. 2012 Nov;67(11):957-63
pubmed: 22684094
Thorax. 2001 Dec;56(12):954-9
pubmed: 11713359
Med Sci Sports Exerc. 1982;14(5):377-81
pubmed: 7154893
Cochrane Database Syst Rev. 2015 Feb 23;(2):CD003793
pubmed: 25705944
Thorax. 2017 Jan;72(1):57-65
pubmed: 27672116
Ann Am Thorac Soc. 2019 Jan;16(1):99-106
pubmed: 30417670
Eur Respir J. 2018 Nov 15;52(5):
pubmed: 30237306
BMC Pulm Med. 2018 Sep 15;18(1):154
pubmed: 30219047
BMJ. 2014 Jul 08;349:g4315
pubmed: 25004917
Int J Chron Obstruct Pulmon Dis. 2020 Feb 26;15:439-460
pubmed: 32161455
Eur Respir J. 2013 Oct;42(4):946-55
pubmed: 23349446
ERJ Open Res. 2015 Oct 06;1(2):
pubmed: 27730157
Am J Respir Crit Care Med. 2013 Oct 15;188(8):e13-64
pubmed: 24127811
Thorax. 2016 Jun;71(6):493-500
pubmed: 27030578
Thorax. 1987 Oct;42(10):773-8
pubmed: 3321537
Am J Respir Crit Care Med. 2021 Nov 1;204(9):1015-1023
pubmed: 34283694
J Cachexia Sarcopenia Muscle. 2017 Oct;8(5):748-758
pubmed: 28608438
Respirology. 2020 Feb;25(2):183-190
pubmed: 31418515
Respirology. 2017 May;22(4):800-819
pubmed: 28339144
J Physiother. 2014 Dec;60(4):181-8
pubmed: 25450482
J Physiother. 2017 Apr;63(2):84-93
pubmed: 28433238
Cochrane Database Syst Rev. 2021 Jan 29;1:CD013040
pubmed: 33511633
Thorax. 2014 Feb;69(2):181-2
pubmed: 23945168
Eur Respir J. 2013 Nov;42(5):1205-15
pubmed: 23397303
Glob Health Epidemiol Genom. 2018 Apr 6;3:e4
pubmed: 29868229
Respir Med. 2018 Apr;137:103-114
pubmed: 29605192