Amino acid infusions in umbilical artery catheters enhance protein administration in infants born at extremely low gestational age.


Journal

Acta paediatrica (Oslo, Norway : 1992)
ISSN: 1651-2227
Titre abrégé: Acta Paediatr
Pays: Norway
ID NLM: 9205968

Informations de publication

Date de publication:
Mar 2022
Historique:
revised: 22 11 2021
received: 30 08 2021
accepted: 24 11 2021
pubmed: 26 11 2021
medline: 8 3 2022
entrez: 25 11 2021
Statut: ppublish

Résumé

It is challenging to provide extremely low gestational age neonates (ELGANs) with adequate protein supply. This study aimed to investigate whether amino acid (AA) infusion in the umbilical artery catheter (UAC) in ELGANs is safe and enhances protein supply and growth. A before and after study including infants born <27 weeks, treated in Uppsala, Sweden, during 2004-2007, compared those receiving normal saline/10% dextrose in water with those receiving AA infusion in the UAC. Data were retrieved from the Extremely Preterm Infants in Sweden Study, hospital records and the Swedish Neonatal Quality Register. Group comparisons, univariate and multivariate analyses were conducted. AA group (n = 41, females 39%) received on average approximately 0.3 g/kg/day more protein during the first postnatal week, compared to control group (n = 30, females 40%) (unstandardised coefficient (B) 0.26, p .001) but no difference was noted during 8-28 postnatal days. The type of infusion was not associated with growth variables. The incidence of neonatal morbidities and UAC-related thrombosis did not differ between the groups. AA infusions in the UACs in ELGANs is safe and enhances protein supply during the first postnatal week. However, this practice is not associated with growth during the first 28 postnatal days.

Identifiants

pubmed: 34822182
doi: 10.1111/apa.16196
doi:

Substances chimiques

Amino Acids 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

536-545

Informations de copyright

© 2021 The Authors. Acta Paediatrica published by John Wiley & Sons Ltd on behalf of Foundation Acta Paediatrica.

Références

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Auteurs

Spyros Gialamas (S)

Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.

Elisabeth Stoltz Sjöström (E)

Department of Food, Nutrition and Culinary Science, Umeå University, Umeå, Sweden.

Barbro Diderholm (B)

Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.

Magnus Domellöf (M)

Department of Clinical Sciences, Pediatrics, Umeå University, Umeå, Sweden.

Fredrik Ahlsson (F)

Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.

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