A Molecular Study on Hepatitis E Virus (HEV) in Pigs in Bulgaria.
Bulgaria
RNA
genotype 3
hepatitis E virus (HEV)
pigs
Journal
Veterinary sciences
ISSN: 2306-7381
Titre abrégé: Vet Sci
Pays: Switzerland
ID NLM: 101680127
Informations de publication
Date de publication:
06 Nov 2021
06 Nov 2021
Historique:
received:
20
10
2021
revised:
29
10
2021
accepted:
04
11
2021
entrez:
25
11
2021
pubmed:
26
11
2021
medline:
26
11
2021
Statut:
epublish
Résumé
Information on hepatitis E virus (HEV) strains circulating in animal reservoirs in Bulgaria is currently lacking. Herein, by screening HEV seropositive sera obtained from Bulgarian swine and wild boars, viral RNA was detected at high prevalence rate (28.2%) in industrial pigs. Sequence analysis of the partial polymerase (RdRp) region revealed the highest genetic correlation with HEVs of genotype (Gt) 3 identified in French and Dutch patients. For three such strains, a 700-bp fragment of the open reading frame 2 gene was generated. On phylogenetic analysis, the Bulgarian strains clustered tightly (93.8-98.3% nt) with human and animal HEVs classified within the Gt3 subtype c.
Identifiants
pubmed: 34822640
pii: vetsci8110267
doi: 10.3390/vetsci8110267
pmc: PMC8619608
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Project "Demetra" (Dipartimenti di Eccellenza 2018 - 2022, CUP_C46C18000530001), funded by the Italian Ministry for Education, University and Research.
ID : CUP_C46C18000530001
Références
Mol Biol Evol. 2018 Jun 1;35(6):1547-1549
pubmed: 29722887
Open Access Maced J Med Sci. 2019 Jan 25;7(3):458-460
pubmed: 30834019
J Virol. 2017 Oct 27;91(22):
pubmed: 28878075
Vector Borne Zoonotic Dis. 2021 Jun;21(6):441-445
pubmed: 33625897
J Gen Virol. 2020 Jul;101(7):692-698
pubmed: 32469300
Rev Med Virol. 2018 Sep;28(5):e1987
pubmed: 29939461
Proc Natl Acad Sci U S A. 1997 Sep 2;94(18):9860-5
pubmed: 9275216
J Hepatol. 2017 May;66(5):1082-1095
pubmed: 27913223
Curr Opin Virol. 2019 Feb;34:10-17
pubmed: 30497051
Emerg Infect Dis. 2012 May;18(5):869-72
pubmed: 22516170
J Virol Methods. 2006 Jan;131(1):65-71
pubmed: 16125257
Front Microbiol. 2021 Jan 28;11:634430
pubmed: 33584599
Animals (Basel). 2020 Aug 28;10(9):
pubmed: 32872096
Viruses. 2021 Mar 16;13(3):
pubmed: 33809748
Arch Virol. 2008;153(9):1703-13
pubmed: 18679765
Vector Borne Zoonotic Dis. 2019 Oct;19(10):767-772
pubmed: 31017536
J Med Virol. 2019 Jan;91(1):132-138
pubmed: 30168583
PLoS One. 2018 Jun 7;13(6):e0198045
pubmed: 29879148
Arch Virol. 2016 Oct;161(10):2829-34
pubmed: 27393602
N Engl J Med. 2008 Feb 21;358(8):811-7
pubmed: 18287603
Pathogens. 2020 Nov 03;9(11):
pubmed: 33153218
Curr Opin Microbiol. 2021 Feb;59:8-15
pubmed: 32810801
J Gen Virol. 2017 Nov;98(11):2645-2646
pubmed: 29022866
Vet Microbiol. 2013 Jul 26;165(1-2):148-54
pubmed: 23434129
J Virol. 2012 Sep;86(17):9134-47
pubmed: 22696648