Drug delivery approaches for HuR-targeted therapy for lung cancer.
CRISPR/Cas-9
Drug delivery
HuR
Lung cancer
Nanomedicine
RBP
siRNA
Journal
Advanced drug delivery reviews
ISSN: 1872-8294
Titre abrégé: Adv Drug Deliv Rev
Pays: Netherlands
ID NLM: 8710523
Informations de publication
Date de publication:
01 2022
01 2022
Historique:
received:
17
10
2021
accepted:
18
11
2021
pubmed:
26
11
2021
medline:
3
3
2022
entrez:
25
11
2021
Statut:
ppublish
Résumé
Lung cancer (LC) is often diagnosed at an advanced stage and conventional treatments for disease management have limitations associated with them. Novel therapeutic targets are thus avidly sought for the effective management of LC. RNA binding proteins (RBPs) have been convincingly established as key players in tumorigenesis, and their dysregulation is linked to multiple cancers, including LC. In this context, we review the role of Human antigen R (HuR), an RBP that is overexpressed in LC, and further associated with various aspects of LC tumor growth and response to therapy. Herein, we describe the role of HuR in LC progression and outline the evidences supporting various pharmacologic and biologic approaches for inhibiting HuR expression and function. These approaches, including use of small molecule inhibitors, siRNAs and shRNAs, have demonstrated favorable results in reducing tumor cell growth, invasion and migration, angiogenesis and metastasis. Hence, HuR has significant potential as a key therapeutic target in LC. Use of siRNA-based approaches, however, have certain limitations that prevent their maximal exploitation as cancer therapies. To address this, in the conclusion of this review, we provide a list of nanomedicine-based HuR targeting approaches currently being employed for siRNA and shRNA delivery, and provide a rationale for the immense potential therapeutic benefits offered by nanocarrier-based HuR targeting and its promise for treating patients with LC.
Identifiants
pubmed: 34822926
pii: S0169-409X(21)00461-0
doi: 10.1016/j.addr.2021.114068
pmc: PMC8724414
mid: NIHMS1760063
pii:
doi:
Substances chimiques
ELAV-Like Protein 1
0
ELAVL1 protein, human
0
RNA, Small Interfering
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
114068Subventions
Organisme : NCI NIH HHS
ID : R01 CA167516
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA254192
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA225520
Pays : United States
Organisme : BLRD VA
ID : I01 BX003420
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM103639
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA233201
Pays : United States
Informations de copyright
Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Références
Nucleic Acids Res. 2018 Jun 20;46(11):5809-5821
pubmed: 29931370
Nat Rev Neurol. 2018 Jan;14(1):9-21
pubmed: 29192260
Lung Cancer. 2015 Aug;89(2):189-96
pubmed: 26013954
Mol Cell Biol. 2003 Oct;23(20):7177-88
pubmed: 14517288
EMBO J. 1998 Jun 15;17(12):3448-60
pubmed: 9628880
Proc Natl Acad Sci U S A. 2008 Dec 23;105(51):20297-302
pubmed: 19088191
J Mater Chem B. 2020 Apr 8;8(14):2768-2774
pubmed: 32154812
Elife. 2014 Jun 04;3:
pubmed: 24898756
Adv Drug Deliv Rev. 2014 Feb;66:110-6
pubmed: 24384374
Cancer Res. 2001 Mar 1;61(5):2154-61
pubmed: 11280780
Mol Cell. 2016 Aug 18;63(4):696-710
pubmed: 27453046
Gastroenterology. 2013 Jul;145(1):166-175.e8
pubmed: 23541909
Pharmacol Ther. 2018 Aug;188:1-11
pubmed: 29476772
Nucleic Acids Res. 2019 Jan 25;47(2):1011-1029
pubmed: 30418581
Sci Rep. 2019 Jan 29;9(1):845
pubmed: 30696915
Hepatology. 2012 Nov;56(5):1870-82
pubmed: 22576182
Genes Dev. 2013 May 1;27(9):1046-58
pubmed: 23618873
J Biol Chem. 2017 Oct 13;292(41):16999-17010
pubmed: 28790173
Oncotarget. 2016 Oct 4;7(40):64820-64835
pubmed: 27588488
BMC Mol Biol. 2017 Jul 20;18(1):19
pubmed: 28728573
Cancer Res. 2021 Apr 15;81(8):2220-2233
pubmed: 33602784
J Thorac Oncol. 2009 Mar;4(3):284-90
pubmed: 19190516
Cancers (Basel). 2019 Apr 29;11(5):
pubmed: 31035440
Mol Cancer Ther. 2019 Jul;18(7):1243-1254
pubmed: 31064870
Clin Transl Oncol. 2014 Oct;16(10):886-91
pubmed: 24522888
Biotechnol Lett. 2018 Apr;40(4):623-631
pubmed: 29344850
Mol Cancer Ther. 2017 Aug;16(8):1470-1486
pubmed: 28572169
Cancer Cell. 2010 Jul 13;18(1):52-62
pubmed: 20609352
Int J Cancer. 2010 Apr 15;126(8):1817-1827
pubmed: 19697322
Curr Drug Deliv. 2017;14(1):36-46
pubmed: 27538460
Oncotarget. 2016 Nov 8;7(45):74043-74058
pubmed: 27677075
ACS Chem Biol. 2015 Jun 19;10(6):1476-84
pubmed: 25750985
Ann Oncol. 2006 Aug;17(8):1263-8
pubmed: 16740598
Neoplasia. 2016 Nov;18(11):674-688
pubmed: 27764700
Tumour Biol. 2017 Apr;39(4):1010428317695928
pubmed: 28381175
Int J Pharm. 2018 Sep 5;548(1):707-720
pubmed: 30012508
Hum Mol Genet. 2016 Jun 15;25(12):2514-2524
pubmed: 27206983
Histol Histopathol. 2012 May;27(5):617-26
pubmed: 22419026
ACS Nano. 2019 Dec 24;13(12):13853-13865
pubmed: 31479239
World J Gastroenterol. 2015 Dec 14;21(46):13004-19
pubmed: 26675757
Aging (Albany NY). 2019 Sep 16;11(18):7473-7491
pubmed: 31527303
Nat Commun. 2019 Sep 13;10(1):4171
pubmed: 31519904
Genes Dev. 2008 Jul 1;22(13):1804-15
pubmed: 18593881
Nature. 2017 Mar 23;543(7646):568-572
pubmed: 28297718
Oncotarget. 2015 Sep 29;6(29):27312-31
pubmed: 26314962
Mol Cell Biol. 2008 Apr;28(8):2608-25
pubmed: 18285462
Anticancer Agents Med Chem. 2019;19(5):580-586
pubmed: 30451118
Nat Rev Drug Discov. 2020 Oct;19(10):672
pubmed: 32873921
J Nanobiotechnology. 2016 Jun 21;14(1):47
pubmed: 27328938
Cancers (Basel). 2020 Jun 18;12(6):
pubmed: 32570729
J Am Chem Soc. 2015 Feb 18;137(6):2140-54
pubmed: 25474531
Commun Biol. 2020 Apr 24;3(1):193
pubmed: 32332873
Mol Cell Biol. 2018 Jan 16;38(3):
pubmed: 29133460
Hepatology. 2012 Apr;55(4):1237-48
pubmed: 22095636
Wiley Interdiscip Rev RNA. 2020 May;11(3):e1581
pubmed: 31970930
Mol Cancer. 2012 Mar 21;11:13
pubmed: 22436134
Sci Rep. 2016 Feb 25;6:22141
pubmed: 26912347
Trends Cardiovasc Med. 2015 Nov;25(8):676-83
pubmed: 25801788
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2020 Jul;12(4):e1621
pubmed: 32131140
Free Radic Biol Med. 2015 Feb;79:217-27
pubmed: 25528059
Int J Oncol. 2002 Nov;21(5):997-1001
pubmed: 12370746
AAPS J. 2017 Mar;19(2):475-486
pubmed: 27882487
Cancer Res. 2006 Aug 15;66(16):7948-56
pubmed: 16912169
Biomed Pharmacother. 2017 Jul;91:788-795
pubmed: 28501005
Cell Death Dis. 2020 Nov 20;11(11):995
pubmed: 33219221
Nucleic Acids Res. 1997 Sep 15;25(18):3564-9
pubmed: 9278474
J Nanobiotechnology. 2021 Jun 9;19(1):172
pubmed: 34107976
Cancer Med. 2016 Jul;5(7):1588-98
pubmed: 27075229
Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):3469-74
pubmed: 25733852
Cancer Res. 2009 Jun 1;69(11):4567-72
pubmed: 19487279
PLoS One. 2013;8(3):e59095
pubmed: 23516604
Cancers (Basel). 2021 Jan 07;13(2):
pubmed: 33430354
Front Oncol. 2021 Jun 14;11:645832
pubmed: 34195070
Mol Carcinog. 2000 Jun;28(2):76-83
pubmed: 10900464
Pharmacol Ther. 2019 Nov;203:107390
pubmed: 31302171
Biochem Biophys Res Commun. 2007 Apr 27;356(1):318-21
pubmed: 17350594
Cancer Gene Ther. 2015 Dec;22(12):581-90
pubmed: 26494555
Neurol Genet. 2019 Apr 01;5(2):e323
pubmed: 31119194
Carcinogenesis. 2014 Sep;35(9):1983-92
pubmed: 24692066
Front Pharmacol. 2019 Mar 29;10:305
pubmed: 30983999
Methods Mol Biol. 2013;942:205-32
pubmed: 23027054
Oncotarget. 2016 Jul 19;7(29):45249-45262
pubmed: 27303922
Mult Scler Relat Disord. 2020 Jun;41:102048
pubmed: 32200342
Oncotarget. 2016 Jan 12;7(2):1895-911
pubmed: 26672765
J Hematol Oncol. 2020 Jul 11;13(1):90
pubmed: 32653017
J Exp Clin Cancer Res. 2012 Apr 26;31:36
pubmed: 22537942
Protein Pept Lett. 2020;27(10):931-944
pubmed: 32264803
Mol Cell Biol. 2011 Sep;31(18):3773-89
pubmed: 21746880
Adv Pharm Bull. 2014 Dec;4(4):313-21
pubmed: 25436185
Mol Cell Biol. 2013 May;33(10):2029-46
pubmed: 23478261
Oncotarget. 2013 May;4(5):739-50
pubmed: 23715514
Oncol Rep. 2011 Jul;26(1):237-45
pubmed: 21503589
Cell Mol Life Sci. 2001 Feb;58(2):266-77
pubmed: 11289308
Nanomedicine. 2018 Feb;14(2):373-384
pubmed: 29155362
Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2987-92
pubmed: 14981256
World J Clin Cases. 2019 Jan 26;7(2):171-190
pubmed: 30705894
Hum Genet. 1997 Jan;99(1):32-3
pubmed: 9003489
J Control Release. 2017 Nov 28;266:17-26
pubmed: 28911805
Am J Physiol Cell Physiol. 2020 Mar 1;318(3):C605-C614
pubmed: 31940247
Mol Cell. 2007 Feb 23;25(4):543-57
pubmed: 17317627
PLoS One. 2017 Oct 2;12(10):e0185625
pubmed: 28968471
Gland Surg. 2014 Aug;3(3):203-6
pubmed: 25207213
Methods Mol Biol. 2010;624:25-37
pubmed: 20217587
J Cell Physiol. 2021 Oct;236(10):6836-6851
pubmed: 33855709
Int J Nanomedicine. 2021 Apr 12;16:2803-2818
pubmed: 33880025
Mol Cancer. 2019 Nov 13;18(1):158
pubmed: 31718709
Cancer Lett. 2018 May 1;421:145-151
pubmed: 29471005
Oncol Res. 2016;23(1-2):61-8
pubmed: 26802652
Lancet. 2016 Sep 3;388(10048):1012-24
pubmed: 27598681
Int J Med Sci. 2017 Apr 9;14(5):452-461
pubmed: 28539821
Nat Rev Mol Cell Biol. 2020 Oct;21(10):585-606
pubmed: 32457507
Oncol Rep. 2017 Dec;38(6):3659-3667
pubmed: 29039571
J Virol. 2005 Jan;79(1):472-85
pubmed: 15596840
Mol Ther Nucleic Acids. 2019 Mar 1;14:142-157
pubmed: 30594893
Nat Rev Dis Primers. 2015 May 21;1:15009
pubmed: 27188576
Biochim Biophys Acta Mol Basis Dis. 2018 Oct;1864(10):3099-3108
pubmed: 29859241
Nucleic Acids Res. 2014 Jan;42(2):1196-208
pubmed: 24106086
Nat Chem Biol. 2007 Aug;3(8):508-15
pubmed: 17632515
Cell Physiol Biochem. 2016;40(5):1039-1051
pubmed: 27941336
Mol Cell Biol. 2012 Mar;32(5):929-40
pubmed: 22215620
Circulation. 2021 May 18;143(20):2007-2022
pubmed: 33663221
Cell Struct Funct. 2010;35(2):95-105
pubmed: 20953064
Int J Oncol. 2008 Feb;32(2):341-7
pubmed: 18202756
Pharmaceutics. 2017 Mar 27;9(2):
pubmed: 28346375
Cell Death Dis. 2011 Jun 16;2:e173
pubmed: 21677688
PLoS One. 2017 Feb 24;12(2):e0172787
pubmed: 28235063
Pharmacol Res. 2016 Sep;111:713-720
pubmed: 27475885
Int J Mol Med. 2018 Nov;42(5):2930-2942
pubmed: 30226552
J Cell Biochem. 2010 Oct 15;111(3):727-34
pubmed: 20626035
Biochim Biophys Acta. 2011 Sep;1813(9):1663-7
pubmed: 21315776
Nat Rev Genet. 2014 Dec;15(12):829-45
pubmed: 25365966
Int J Biomed Sci. 2017 Jun;13(2):48-57
pubmed: 28824341
Oncotarget. 2016 Mar 29;7(13):16760-72
pubmed: 26919236
Mol Cancer Ther. 2020 Nov;19(11):2267-2277
pubmed: 32879054
Nucleic Acids Res. 2016 Feb 18;44(3):1227-46
pubmed: 26717985
Mol Cancer. 2018 Jan 19;17(1):11
pubmed: 29351796
Surg Oncol. 2020 Sep;34:31-39
pubmed: 32891348
Int J Oncol. 2016 Nov;49(5):2001-2010
pubmed: 27826622
Nature. 2018 Aug;560(7718):382-386
pubmed: 30089911
Cell Cycle. 2008 Nov 1;7(21):3371-7
pubmed: 18948743
AAPS J. 2021 Feb 14;23(2):30
pubmed: 33586060
Sci Rep. 2017 May 12;7(1):1862
pubmed: 28500326
Genes Dev. 2018 Sep 1;32(17-18):1161-1174
pubmed: 30115631
Cell Signal. 2013 Dec;25(12):2485-95
pubmed: 23978401
Clin Exp Pharmacol Physiol. 2008 Nov;35(11):1371-6
pubmed: 18565190
Cell Death Differ. 2019 Jul;26(7):1346-1364
pubmed: 30341421
Cancer. 1995 Jul 1;76(1):20-5
pubmed: 8630872
Mol Cancer Res. 2019 Oct;17(10):2029-2041
pubmed: 31383722
Cancer Med. 2020 Nov;9(22):8612-8623
pubmed: 33016643
Nature. 2013 Jul 11;499(7457):172-7
pubmed: 23846655
Mol Ther. 2017 Jul 5;25(7):1580-1587
pubmed: 28392161
Proc Natl Acad Sci U S A. 2016 Jan 19;113(3):520-5
pubmed: 26729861
Nucleic Acids Res. 2020 Jan 8;48(D1):D307-D313
pubmed: 31598693
FASEB J. 2020 Nov;34(11):15047-15061
pubmed: 32954540
Invest New Drugs. 2019 Oct;37(5):1107-1116
pubmed: 30612309
Cell Rep. 2014 Apr 24;7(2):539-551
pubmed: 24703842
Clin Lab. 2016;62(4):711-8
pubmed: 27215092
Zhongguo Fei Ai Za Zhi. 2010 Dec;13(12):1132-5
pubmed: 21159249
J Cell Sci. 1998 Nov;111 ( Pt 21):3145-56
pubmed: 9763509
Nat Rev Cancer. 2018 Jan;18(1):5-18
pubmed: 29170536
J Exp Clin Cancer Res. 2019 Nov 27;38(1):478
pubmed: 31775888
Exp Cell Res. 2015 Jan 1;330(1):66-80
pubmed: 25240929
Mol Cancer Ther. 2016 Sep;15(9):2232-43
pubmed: 27371730
Oncol Lett. 2017 Apr;13(4):2274-2280
pubmed: 28454391
Cancer Res. 2017 Sep 15;77(18):5011-5025
pubmed: 28687616
Antisense Res Dev. 1991 Summer;1(2):141-51
pubmed: 1841656
J Biol Chem. 1996 Apr 5;271(14):8144-51
pubmed: 8626503
Wiley Interdiscip Rev RNA. 2017 Jan;8(1):
pubmed: 27307117
RNA Biol. 2020 Feb;17(2):211-226
pubmed: 31607220
Mol Cancer Res. 2012 Jan;10(1):167-80
pubmed: 22049153
Cell Cycle. 2007 Jun 1;6(11):1288-92
pubmed: 17534146
Biomedicines. 2021 Jan 27;9(2):
pubmed: 33513829
J Cell Mol Med. 2020 Feb;24(4):2423-2433
pubmed: 31951319
Sci Rep. 2017 Aug 30;7(1):9694
pubmed: 28855578
Cancer Lett. 2017 May 1;393:103-112
pubmed: 28219770
J Biol Chem. 2013 Feb 15;288(7):4908-21
pubmed: 23223443
Vasc Health Risk Manag. 2006;2(3):213-9
pubmed: 17326328
Transl Res. 2019 Dec;214:62-91
pubmed: 31369717
Oncogene. 2016 Mar 31;35(13):1725-35
pubmed: 26096938
J Immunol. 2015 Oct 1;195(7):3449-62
pubmed: 26320247
Nat Immunol. 2015 Apr;16(4):415-25
pubmed: 25706746
Tumour Biol. 2015 Jan;36(1):315-27
pubmed: 25252849
Curr Diabetes Rev. 2006 Aug;2(3):363-6
pubmed: 18220641
Cancer Biol Ther. 2019;20(7):979-988
pubmed: 30991885
Biomaterials. 2016 Feb;79:56-68
pubmed: 26695117
Mol Cancer Res. 2011 May;9(5):648-59
pubmed: 21498545
Adv Exp Med Biol. 2018;995:65-95
pubmed: 30539506
Gene Ther. 2022 Apr;29(3-4):157-170
pubmed: 34363036
Chem Biol Interact. 2019 Aug 25;309:108720
pubmed: 31226287
J Cell Physiol. 2020 Feb;235(2):1576-1587
pubmed: 31313286
J Thorac Dis. 2021 Mar;13(3):1370-1379
pubmed: 33841930
J Exp Clin Cancer Res. 2020 Jun 20;39(1):117
pubmed: 32563270
Methods Mol Biol. 2020;2059:167-189
pubmed: 31435921
J Neurochem. 2015 Mar;132(6):642-56
pubmed: 25581122
Nat Commun. 2021 Apr 23;12(1):2397
pubmed: 33893274
Sci Rep. 2016 Jun 08;6:27611
pubmed: 27271770
Theranostics. 2021 Jan 1;11(3):1396-1411
pubmed: 33391541
J Genet Genomics. 2021 Jul 20;48(7):606-617
pubmed: 34362680
Cancer Lett. 2005 Jun 1;223(1):137-42
pubmed: 15890246
Cell Signal. 2008 Dec;20(12):2165-73
pubmed: 18585896
Sci Rep. 2016 Dec 12;6:38541
pubmed: 27941871
Clin Cancer Res. 2013 Nov 15;19(22):6074-83
pubmed: 23958744
Cell Rep. 2021 May 25;35(8):109178
pubmed: 34038724
Oncol Lett. 2020 Apr;19(4):3111-3122
pubmed: 32218862
J Laryngol Otol. 2010 Nov;124(11):1183-9
pubmed: 20519042
Nanoscale Res Lett. 2014 May 21;9(1):247
pubmed: 24994950
Arterioscler Thromb Vasc Biol. 2020 Apr;40(4):943-957
pubmed: 32075416
RNA Biol. 2014;11(10):1250-61
pubmed: 25584704
Oncogene. 2003 Oct 16;22(46):7146-54
pubmed: 14562043
Mol Cancer. 2019 Nov 21;18(1):167
pubmed: 31752906
J Pathol. 2013 Mar;229(4):630-9
pubmed: 23132731
Eur J Pharmacol. 2019 Jun 15;853:345-352
pubmed: 30981768
J Hematol Oncol. 2019 Jun 7;12(1):55
pubmed: 31174564
Cell Mol Life Sci. 2009 Apr;66(7):1239-56
pubmed: 19099192
J Mol Biol. 2006 Aug 18;361(3):470-81
pubmed: 16854432
J Clin Invest. 2009 Dec;119(12):3530-43
pubmed: 19884656
J Clin Transl Res. 2021 Mar 16;7(2):140-155
pubmed: 34104817
J Biol Chem. 2011 Oct 14;286(41):35499-35508
pubmed: 21862584
Proc Natl Acad Sci U S A. 2016 Jun 21;113(25):6955-60
pubmed: 27274057
Cell Death Dis. 2020 Dec 2;11(12):1031
pubmed: 33268793
Proteomics Clin Appl. 2015 Apr;9(3-4):358-67
pubmed: 25684126
Genet Mol Biol. 2017 Jan-Mar;40(1):22-30
pubmed: 28463381
Br J Cancer. 2011 Mar 1;104(5):819-29
pubmed: 21285980
Atherosclerosis. 2007 Nov;195(1):e134-43
pubmed: 17531241
Wiley Interdiscip Rev RNA. 2017 Jan;8(1):
pubmed: 27659605
EBioMedicine. 2019 Jul;45:208-219
pubmed: 31221586
Cancers (Basel). 2021 Jan 06;13(2):
pubmed: 33418925
Am J Cancer Res. 2020 Mar 01;10(3):727-742
pubmed: 32266087
Proc Natl Acad Sci U S A. 2013 Jun 4;110(23):9409-14
pubmed: 23676272
Mol Biol Cell. 2007 Jun;18(6):2137-48
pubmed: 17392515
Pharmaceuticals (Basel). 2013 Feb 04;6(2):161-83
pubmed: 24275946
J Biol Chem. 2003 Dec 19;278(51):51758-69
pubmed: 14523003
Curr Opin Biotechnol. 2007 Feb;18(1):26-30
pubmed: 17254762
J Clin Invest. 2020 Jul 1;130(7):3848-3864
pubmed: 32315290
Mol Cancer Ther. 2013 Jul;12(7):1202-12
pubmed: 23619299
Nat Rev Mol Cell Biol. 2007 Jun;8(6):479-90
pubmed: 17473849
Front Biosci (Landmark Ed). 2012 Jan 01;17(1):189-205
pubmed: 22201738
Pharmaceutics. 2018 Aug 08;10(3):
pubmed: 30096839
Mol Cancer. 2021 May 29;20(1):80
pubmed: 34051805
Nano Rev. 2012;3:
pubmed: 23240070
Int J Med Sci. 2017 Jul 18;14(8):785-790
pubmed: 28824314
Annu Rev Pharmacol Toxicol. 2010;50:259-93
pubmed: 20055705
Cancer Cell Int. 2019 Apr 02;19:79
pubmed: 30976203
Biomolecules. 2019 Aug 03;9(8):
pubmed: 31382626
J Laryngol Otol. 2013 Dec;127(12):1194-202
pubmed: 24300127
AAPS J. 2018 Jul 9;20(5):82
pubmed: 29987691
Arterioscler Thromb Vasc Biol. 2014 Jan;34(1):8-16
pubmed: 24158514
PLoS One. 2017 Apr 17;12(4):e0175471
pubmed: 28414767
Oncology. 2009;76(6):420-9
pubmed: 19420963
Nat Commun. 2020 Jan 10;11(1):213
pubmed: 31924774
IEEE Trans Nanobioscience. 2016 Dec;15(8):849-863
pubmed: 28092499
RNA Biol. 2017 Mar 4;14(3):361-369
pubmed: 28080204
Nanoscale Res Lett. 2013 Feb 22;8(1):102
pubmed: 23432972
Acta Biochim Biophys Sin (Shanghai). 2017 Sep 1;49(9):753-763
pubmed: 28910975
Oncol Lett. 2014 Apr;7(4):1073-1077
pubmed: 24944671
J Exp Clin Cancer Res. 2019 Jan 28;38(1):37
pubmed: 30691465
Int J Mol Sci. 2013 May 10;14(5):10015-41
pubmed: 23665903
Pain. 2021 May 1;162(5):1500-1510
pubmed: 33259457
Cancer Res. 2016 May 1;76(9):2626-36
pubmed: 27197265
Mol Cell Biol. 2009 May;29(10):2762-76
pubmed: 19307312
Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):268-277
pubmed: 30600739
Adv Exp Med Biol. 2021;1310:401-447
pubmed: 33834444
Curr Opin Genet Dev. 2018 Feb;48:112-120
pubmed: 29216518
Glia. 2019 Dec;67(12):2424-2439
pubmed: 31400163
J Nanobiotechnology. 2019 Jan 29;17(1):19
pubmed: 30696428
Med Oncol. 2011 Dec;28 Suppl 1:S577-85
pubmed: 21046284
Mol Cell. 2011 Feb 18;41(4):419-31
pubmed: 21329880
Cancers (Basel). 2019 Dec 13;11(12):
pubmed: 31847141
Mol Cancer Res. 2017 Jun;15(6):696-707
pubmed: 28242812
Cytokine Growth Factor Rev. 2021 Feb;57:19-26
pubmed: 33160830
Cancer Res. 2016 Mar 15;76(6):1549-59
pubmed: 26921342
Mol Cancer. 2020 Jun 29;19(1):112
pubmed: 32600329
Immunotherapy. 2017 Mar;9(4):347-360
pubmed: 28303764
Expert Opin Drug Deliv. 2013 Apr;10(4):451-68
pubmed: 23316711
J Biol Chem. 2021 Aug;297(2):100997
pubmed: 34302808
RNA Biol. 2013 Feb;10(2):277-86
pubmed: 23324604
Acta Pharm Sin B. 2020 Aug;10(8):1414-1425
pubmed: 32963940
J Biol Chem. 2015 May 29;290(22):13958-71
pubmed: 25882842
Nat Commun. 2013;4:2939
pubmed: 24326307
Cell Death Dis. 2021 Apr 9;12(4):385
pubmed: 33837179
Exp Eye Res. 2017 Aug;161:116-123
pubmed: 28619505
Cancer Med. 2018 Dec;7(12):6269-6280
pubmed: 30449075
Nucleic Acids Res. 2017 Sep 19;45(16):9514-9527
pubmed: 28934484
Cancer Manag Res. 2020 Sep 25;12:9033-9043
pubmed: 33061598
PLoS Genet. 2014 Apr 10;10(4):e1004289
pubmed: 24722255
Signal Transduct Target Ther. 2021 Mar 5;6(1):108
pubmed: 33664238
Cell Death Differ. 2019 Nov;26(11):2329-2343
pubmed: 30787392
Oncogene. 2021 Mar;40(12):2230-2242
pubmed: 33649535
J Med Chem. 2018 Feb 22;61(4):1483-1498
pubmed: 29313684
Front Genet. 2021 May 12;12:673286
pubmed: 34054927
Nat Rev Mol Cell Biol. 2002 Mar;3(3):195-205
pubmed: 11994740
Int J Mol Sci. 2018 Jan 30;19(2):
pubmed: 29385744
Mol Cell. 2012 Aug 24;47(4):648-55
pubmed: 22841487
Leukemia. 2018 Sep;32(9):1948-1957
pubmed: 29487387
Neuroreport. 2021 Jun 9;32(9):824-832
pubmed: 33994531
Sci Rep. 2017 Dec 8;7(1):17233
pubmed: 29222492
RNA. 2008 Dec;14(12):2538-49
pubmed: 18952824
Int J Mol Sci. 2020 Oct 03;21(19):
pubmed: 33023062
Life (Basel). 2021 Jul 13;11(7):
pubmed: 34357054
Thorac Cancer. 2021 Sep;12(18):2449-2457
pubmed: 34342121
Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15293-8
pubmed: 9860962
Oncotarget. 2017 May 11;8(47):81994-82005
pubmed: 29137239
Nat Commun. 2019 Sep 4;10(1):3983
pubmed: 31484925
Mol Biol Cell. 2011 Aug 15;22(16):2875-85
pubmed: 21737689
J Thorac Dis. 2020 Oct;12(10):6240-6252
pubmed: 33209463
Nature. 2004 Sep 16;431(7006):343-9
pubmed: 15372041
Mod Pathol. 2011 Oct;24(10):1336-47
pubmed: 21572400
Cancers (Basel). 2020 Sep 21;12(9):
pubmed: 32967226
Sci Rep. 2019 May 14;9(1):7374
pubmed: 31089242
Cell Cycle. 2016 Nov 16;15(22):3094-3104
pubmed: 27767378
Mol Cell Biol. 2010 Mar;30(6):1397-410
pubmed: 20086103
Sci Rep. 2015 Nov 10;5:16478
pubmed: 26553968