Highly accurate and label-free discrimination of single cancer cell using a plasmonic oxide-based nanoprobe.

Biosensing Techniques HEK293 Cells Humans Leukocytes, Mononuclear Metal Nanoparticles Neoplasms / diagnosis Oxides Spectrum Analysis, Raman
Colorimetric cell detection Plasmon oxide Single cell detection Surface enhanced Raman spectroscopy

Journal

Biosensors & bioelectronics
ISSN: 1873-4235
Titre abrégé: Biosens Bioelectron
Pays: England
ID NLM: 9001289

Informations de publication

Date de publication:
15 Feb 2022
Historique:
received: 01 08 2021
revised: 01 11 2021
accepted: 14 11 2021
pubmed: 27 11 2021
medline: 5 1 2022
entrez: 26 11 2021
Statut: ppublish

Résumé

The detection of cancer cells at the single-cell level enables many novel functionalities such as next-generation cancer prognosis and accurate cellular analysis. While surface-enhanced Raman spectroscopy (SERS) has been widely considered as an effective tool in a low-cost and label-free manner, however, it is challenging to discriminate single cancer cells with an accuracy above 90% mainly due to the poor biocompatibility of the noble-metal-based SERS agents. Here, we report a dual-functional nanoprobe based on dopant-driven plasmonic oxides, demonstrating a maximum accuracy above 90% in distinguishing single THP-1 cell from peripheral blood mononuclear cell (PBMC) and human embryonic kidney (HEK) 293 from human macrophage cell line U937 based on their SERS patterns. Furthermore, this nanoprobe can be triggered by the bio-redox response from individual cells towards stimuli, empowering another complementary colorimetric cell detection, approximately achieving the unity discrimination accuracy at a single-cell level. Our strategy could potentially enable the future accurate and low-cost detection of cancer cells from mixed cell samples.

Identifiants

DOI: 10.1016/j.bios.2021.113814 PMID: 34823964
pubmed: 34823964
pii: S0956-5663(21)00851-4
doi: 10.1016/j.bios.2021.113814
pii:
doi:

Substances chimiques

Oxides 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

113814

Informations de copyright

Copyright © 2021 Elsevier B.V. All rights reserved.

Auteurs

Bao Yue Zhang (BY)

School of Engineering, RMIT University, Melbourne, Victoria, 3000, Australia. Electronic address: baoyue.zhang@rmit.edu.au.

Pengju Yin (P)

School of Mathematics and Physics, Hebei University of Engineering, Handan, 056038, China; School of Life Science and Technology, Xidian University, Xi'an, 710126, China.

Yihong Hu (Y)

School of Engineering, RMIT University, Melbourne, Victoria, 3000, Australia.

Crispin Szydzik (C)

School of Engineering, RMIT University, Melbourne, Victoria, 3000, Australia; The Australian Centre for Blood Diseases, Monash University, Melbourne, Victoria, 3004, Australia.

Muhammad Waqas Khan (MW)

School of Engineering, RMIT University, Melbourne, Victoria, 3000, Australia; Manufacturing, CSIRO, Clayton, Victoria, 3168, Australia.

Kai Xu (K)

School of Engineering, RMIT University, Melbourne, Victoria, 3000, Australia.

Peter Thurgood (P)

School of Engineering, RMIT University, Melbourne, Victoria, 3000, Australia.

Nasir Mahmood (N)

School of Engineering, RMIT University, Melbourne, Victoria, 3000, Australia.

Chaitali Dekiwadia (C)

RMIT Microscopy and Microanalysis Facility (RMMF), RMIT University, Melbourne, 3001, Australia.

Sanjida Afrin (S)

School of Engineering, RMIT University, Melbourne, Victoria, 3000, Australia.

Yunyi Yang (Y)

Faculty of Science, Engineering and Technology, Swinburne University of Technology, Hawthorn, VIC, 3122 Australia.

Qijie Ma (Q)

School of Engineering, RMIT University, Melbourne, Victoria, 3000, Australia.

Chris F McConville (CF)

Institute for Frontier Materials (IFM), Deakin University, Waurn Ponds, VIC, 3216, Australia.

Khashayar Khoshmanesh (K)

School of Engineering, RMIT University, Melbourne, Victoria, 3000, Australia.

Arnan Mitchell (A)

School of Engineering, RMIT University, Melbourne, Victoria, 3000, Australia.

Bo Hu (B)

School of Life Science and Technology, Xidian University, Xi'an, 710126, China.

Sara Baratchi (S)

School of Health and Biomedical Sciences, RMIT University, Bundoora, VIC, 3083 Australia; Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia. Electronic address: sara.baratchi@rmit.edu.au.

Jian Zhen Ou (JZ)

School of Engineering, RMIT University, Melbourne, Victoria, 3000, Australia. Electronic address: jianzhen.ou@rmit.edu.au.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Techniques d'investigation › Techniques de sonde moléculaire › Techniques de biocapteur › Highly accurate and label-free discrimination...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules HEK293 › Highly accurate and label-free discrimination...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Highly accurate and label-free discrimination...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Highly accurate and label-free discrimination...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Nanostructures › Nanoparticules › Nanoparticules métalliques › Highly accurate and label-free discrimination...
questionsmedicales.fr › Tumeurs › Highly accurate and label-free discrimination...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Oxydes › Highly accurate and label-free discrimination...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse spectrale › Analyse spectrale Raman › Highly accurate and label-free discrimination...