Current progress of rehabilitative strategies in stem cell therapy for spinal cord injury: a review.
Journal
NPJ Regenerative medicine
ISSN: 2057-3995
Titre abrégé: NPJ Regen Med
Pays: United States
ID NLM: 101699846
Informations de publication
Date de publication:
25 Nov 2021
25 Nov 2021
Historique:
received:
19
02
2021
accepted:
21
10
2021
entrez:
26
11
2021
pubmed:
27
11
2021
medline:
27
11
2021
Statut:
epublish
Résumé
Stem cell-based regenerative therapy has opened an avenue for functional recovery of patients with spinal cord injury (SCI). Regenerative rehabilitation is attracting wide attention owing to its synergistic effects, feasibility, non-invasiveness, and diverse and systemic properties. In this review article, we summarize the features of rehabilitation, describe the mechanism of combinatorial treatment, and discuss regenerative rehabilitation in the context of SCI. Although conventional rehabilitative methods have commonly been implemented alone, especially in studies of acute-to-subacute SCI, the combinatorial effects of intensive and advanced methods, including various neurorehabilitative approaches, have also been reported. Separating the concept of combined rehabilitation from regenerative rehabilitation, we suggest that the main roles of regenerative rehabilitation can be categorized as conditioning/reconditioning, functional training, and physical exercise, all of which are indispensable for enhancing functional recovery achieved using stem cell therapies.
Identifiants
pubmed: 34824291
doi: 10.1038/s41536-021-00191-7
pii: 10.1038/s41536-021-00191-7
pmc: PMC8616941
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
81Subventions
Organisme : Japan Agency for Medical Research and Development (AMED)
ID : JP20bm0204001
Organisme : Japan Agency for Medical Research and Development (AMED)
ID : JP19bm0204001
Organisme : Japan Agency for Medical Research and Development (AMED)
ID : JP18bk0104017
Organisme : Japan Agency for Medical Research and Development (AMED)
ID : JP20bm0204001
Organisme : Japan Agency for Medical Research and Development (AMED)
ID : JP19bm0204001
Organisme : Japan Agency for Medical Research and Development (AMED)
ID : JP18bk0104017
Informations de copyright
© 2021. The Author(s).
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