Treatment with sodium (
2-hydroxyglutarate
Hmox1
Ischemia-reperfusion injury
Liver
Oxidative stress
Pdk1
Proinflammatory cytokines
Vegfa
Journal
PeerJ
ISSN: 2167-8359
Titre abrégé: PeerJ
Pays: United States
ID NLM: 101603425
Informations de publication
Date de publication:
2021
2021
Historique:
received:
24
05
2021
accepted:
11
10
2021
entrez:
26
11
2021
pubmed:
27
11
2021
medline:
27
11
2021
Statut:
epublish
Résumé
Ischemia-reperfusion (IR) injury is one of the leading causes of early graft dysfunction in liver transplantation. Techniques such as ischemic preconditioning protect the graft through the activation of the hypoxia-inducible factors (HIF), which are downregulated by the EGLN family of prolyl-4-hydroxylases, a potential biological target for the development of strategies based on pharmacological preconditioning. For that reason, this study aims to evaluate the effect of the EGLN inhibitor sodium ( Twenty-eight female Wistar rats were divided into the following groups: sham (SH, The administration of (
Sections du résumé
BACKGROUND
BACKGROUND
Ischemia-reperfusion (IR) injury is one of the leading causes of early graft dysfunction in liver transplantation. Techniques such as ischemic preconditioning protect the graft through the activation of the hypoxia-inducible factors (HIF), which are downregulated by the EGLN family of prolyl-4-hydroxylases, a potential biological target for the development of strategies based on pharmacological preconditioning. For that reason, this study aims to evaluate the effect of the EGLN inhibitor sodium (
METHODS
METHODS
Twenty-eight female Wistar rats were divided into the following groups: sham (SH,
RESULTS
RESULTS
The administration of (
Identifiants
pubmed: 34824916
doi: 10.7717/peerj.12426
pii: 12426
pmc: PMC8592047
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e12426Informations de copyright
©2021 Cienfuegos-Pecina et al.
Déclaration de conflit d'intérêts
The authors declare there are no competing interests.
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