A histopathological classification scheme for abdominal aortic aneurysm disease.
Abdominal aortic aneurysm
Classification
Histology
Thoracic aortic aneurysm
Vascular remodeling
Journal
JVS-vascular science
ISSN: 2666-3503
Titre abrégé: JVS Vasc Sci
Pays: United States
ID NLM: 101767073
Informations de publication
Date de publication:
2021
2021
Historique:
received:
18
05
2021
accepted:
08
09
2021
entrez:
26
11
2021
pubmed:
27
11
2021
medline:
27
11
2021
Statut:
epublish
Résumé
Two consensus histopathological classifications for thoracic aortic aneurysms (TAAs) and inflammatory aortic diseases have been issued to facilitate clinical decision-making and inter-study comparison. However, these consensus classifications do not specifically encompass abdominal aortic aneurysms (AAAs). Given its high prevalence and the existing profound pathophysiologic knowledge gaps, extension of the consensus classification scheme to AAAs would be highly instrumental. The aim of this study was to test the applicability of, and if necessary to adapt, the issued consensus classification schemes for AAAs. Seventy-two AAA anterolateral wall samples were collected during elective and emergency open aneurysm repair performed between 2002 and 2013. Histologic analysis (hematoxylin and eosin and Movat Pentachrome) and (semi-quantitative and qualitative) grading were performed in order to map the histological aspects of AAA. Immunohistochemistry was performed for visualization of aspects of the adaptive and innate immune system, and for a more detailed analysis of atherosclerotic lesions in AAA. Because the existing consensus classification schemes do not adequately capture the aspects of AAA disease, an AAA-specific 11-point histopathological consensus classification was devised. Systematic application of this classification indicated several universal features for AAA (eg, [almost] complete elastolysis), but considerable variation for other aspects (eg, inflammation and atherosclerotic lesions). This first multiparameter histopathological AAA consensus classification illustrates the sharp histological contrasts between thoracic and abdominal aneurysms. The value of the proposed scoring system for AAA disease is illustrated by its discriminatory capacity to identify samples from patients with a nonclassical (genetic) variant of AAA disease.
Identifiants
pubmed: 34825232
doi: 10.1016/j.jvssci.2021.09.001
pii: S2666-3503(21)00022-5
pmc: PMC8605212
doi:
Types de publication
Journal Article
Langues
eng
Pagination
260-273Informations de copyright
© 2021 by the Society for Vascular Surgery. Published by Elsevier Inc.
Références
Int J Cardiol. 2016 Dec 1;224:328-334
pubmed: 27668706
J Am Heart Assoc. 2015 Mar 26;4(4):
pubmed: 25814626
J Vasc Surg. 2018 Jun;67(6):1891-1900.e4
pubmed: 28912007
Oncotarget. 2015 May 30;6(15):12984-96
pubmed: 25944698
J Clin Invest. 1998 Dec 1;102(11):1900-10
pubmed: 9835614
N Engl J Med. 2003 Dec 11;349(24):2316-25
pubmed: 14668457
Cardiovasc Res. 2011 Jul 15;91(2):358-67
pubmed: 21436157
Atherosclerosis. 2010 May;210(1):100-6
pubmed: 20031134
Cardiovasc Pathol. 2016 May-Jun;25(3):247-257
pubmed: 27031798
Nat Rev Cardiol. 2016 Feb;13(2):79-98
pubmed: 26503410
J Vasc Surg. 2001 Aug;34(2):291-9
pubmed: 11496282
Circ Res. 2019 Feb 15;124(4):588-606
pubmed: 30763214
Front Surg. 2016 Jan 25;3:1
pubmed: 26835458
Circ Res. 2014 May 23;114(11):1772-87
pubmed: 24855201
Clin Sci (Lond). 2008 Jun;114(11):687-97
pubmed: 18078385
Cardiovasc Pathol. 2015 Sep-Oct;24(5):267-78
pubmed: 26051917
Cardiovasc Res. 2011 Apr 1;90(1):18-27
pubmed: 21037321
Nat Clin Pract Cardiovasc Med. 2008 Aug;5 Suppl 2:S18-25
pubmed: 18641602
J Am Heart Assoc. 2017 Nov 30;6(12):
pubmed: 29191809
Crit Care. 2016 Oct 21;20(1):319
pubmed: 27765054
Springerplus. 2015 May 16;4:231
pubmed: 26110102
Exp Mol Med. 2019 Dec 19;51(12):1-15
pubmed: 31857579
Cardiovasc Pathol. 2017 Mar - Apr;27:71-75
pubmed: 28189002
BJS Open. 2021 Jan 8;5(1):
pubmed: 33609372
Cardiovasc Res. 2021 Apr 23;117(5):1402-1416
pubmed: 32678909
Cytokine. 2018 Aug;108:96-104
pubmed: 29587155
Expert Rev Cardiovasc Ther. 2015;13(9):975-87
pubmed: 26308600
Eur J Vasc Endovasc Surg. 2020 Mar;59(3):494
pubmed: 31839474
Arterioscler Thromb Vasc Biol. 2010 Jun;30(6):1075-7
pubmed: 20484703
Oncoimmunology. 2017 Dec 18;7(2):e1378844
pubmed: 29416939
Arterioscler Thromb Vasc Biol. 2006 May;26(5):987-94
pubmed: 16497993
Circulation. 2014 Jun 17;129(24):2557-66
pubmed: 24934463
J Thorac Cardiovasc Surg. 2008 Nov;136(5):1123-30
pubmed: 19026791
Nat Rev Cardiol. 2019 Jul;16(7):389-406
pubmed: 30846875