COVID-19-associated immune-mediated encephalitis mimicking acute-onset Creutzfeldt-Jakob disease.
Journal
Annals of clinical and translational neurology
ISSN: 2328-9503
Titre abrégé: Ann Clin Transl Neurol
Pays: United States
ID NLM: 101623278
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
revised:
26
10
2021
received:
01
05
2021
accepted:
03
11
2021
pubmed:
27
11
2021
medline:
24
12
2021
entrez:
26
11
2021
Statut:
ppublish
Résumé
We report a subtype of immune-mediated encephalitis associated with COVID-19, which closely mimics acute-onset sporadic Creutzfeldt-Jakob disease. A 64-year-old man presented with confusion, aphasia, myoclonus, and a silent interstitial pneumonia. He tested positive for SARS-CoV-2. Cognition and myoclonus rapidly deteriorated, EEG evolved to generalized periodic discharges and brain MRI showed multiple cortical DWI hyperintensities. CSF analysis was normal, except for a positive 14-3-3 protein. RT-QuIC analysis was negative. High levels of pro-inflammatory cytokines were present in the CSF and serum. Treatment with steroids and intravenous immunoglobulins produced EEG and clinical improvement, with a good neurological outcome at a 6-month follow-up.
Identifiants
pubmed: 34825771
doi: 10.1002/acn3.51479
pmc: PMC8670319
doi:
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
2314-2318Informations de copyright
© 2021 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.
Références
Brain. 2020 Oct 1;143(10):3104-3120
pubmed: 32637987
Ann Neurol. 2020 Aug;88(2):423-427
pubmed: 32418288
Neuroimage Clin. 2021;30:102523
pubmed: 33636540
J Neurol. 2021 Jun;268(6):2031-2034
pubmed: 32880721
Brain. 2020 Dec 1;143(12):e102
pubmed: 33064794
Nature. 2021 Jul;595(7868):565-571
pubmed: 34153974
J Infect Dis. 2021 Jan 4;223(1):28-37
pubmed: 32986824
Neurology. 2018 Jul 24;91(4):e331-e338
pubmed: 29934424
Cerebrovasc Dis. 2004;18(3):251-3
pubmed: 15305071
Neurol Neuroimmunol Neuroinflamm. 2020 Sep 25;7(6):
pubmed: 32978291
Brain. 2009 Oct;132(Pt 10):2659-68
pubmed: 19773352
Neurology. 2011 May 17;76(20):1711-9
pubmed: 21471469
Pract Neurol. 2017 Apr;17(2):113-121
pubmed: 28153848
Lancet Neurol. 2020 Nov;19(11):919-929
pubmed: 33031735
Neurology. 2012 Oct 2;79(14):1499-506
pubmed: 22993290
Neurology. 2006 Aug 8;67(3):538-9
pubmed: 16894130