Recent Advances in Biotransformation by Cunninghamella Species.
Filamentous fungi
chemical modifications
cytochrome P450
green chemical
metabolism
xenobiotics.
Journal
Current drug metabolism
ISSN: 1875-5453
Titre abrégé: Curr Drug Metab
Pays: Netherlands
ID NLM: 100960533
Informations de publication
Date de publication:
2021
2021
Historique:
received:
12
06
2021
revised:
02
09
2021
accepted:
22
10
2021
pubmed:
27
11
2021
medline:
22
2
2022
entrez:
26
11
2021
Statut:
ppublish
Résumé
The goal of the biotransformation process is to develop structural changes and generate new chemical compounds, which can occur naturally in mammalian and microbial organisms, such as filamentous fungi, and represent a tool to achieve enhanced bioactive compounds. Cunninghamella spp. is among the fungal models most widely used in biotransformation processes at phase I and II reactions, mimicking the metabolism of drugs and xenobiotics in mammals and generating new molecules based on substances of natural and synthetic origin. Therefore, the goal of this review is to highlight the studies involving the biotransformation of Cunninghamella species between January 2015 and March 2021, in addition to updating existing studies to identify the similarities between the human metabolite and Cunninghamella patterns of active compounds, with related advantages and challenges, and providing new tools for further studies in this scope.
Identifiants
pubmed: 34825868
pii: CDM-EPUB-119078
doi: 10.2174/1389200222666211126100023
doi:
Substances chimiques
Biological Factors
0
Xenobiotics
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1035-1064Subventions
Organisme : Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES)
ID : 001
Informations de copyright
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