Germline biallelic mutation affecting the transcription factor Helios causes pleiotropic defects of immunity.


Journal

Science immunology
ISSN: 2470-9468
Titre abrégé: Sci Immunol
Pays: United States
ID NLM: 101688624

Informations de publication

Date de publication:
26 Nov 2021
Historique:
entrez: 26 11 2021
pubmed: 27 11 2021
medline: 8 3 2022
Statut: ppublish

Résumé

Helios, a member of the Ikaros family of transcription factors, is predominantly expressed in developing thymocytes, activated T cells, and regulatory T cells (T

Identifiants

pubmed: 34826259
doi: 10.1126/sciimmunol.abe3981
pmc: PMC7612971
mid: EMS146203
doi:

Substances chimiques

IKZF2 protein, human 0
Interleukin-2 0
Ikaros Transcription Factor 148971-36-2

Types de publication

Journal Article Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

eabe3981

Subventions

Organisme : European Research Council
ID : 820074
Pays : International

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Auteurs

Tala Shahin (T)

St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria.
Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria.
CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria.

Hye Sun Kuehn (HS)

Immunology Service, Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20814, USA.

Mohamed R Shoeb (MR)

St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria.

Lisa Gawriyski (L)

Institute of Biotechnology, Helsinki Institute of Life Science, Proteomics Unit, University of Helsinki, Helsinki, Finland.

Sarah Giuliani (S)

St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria.
Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria.

Peter Repiscak (P)

St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria.

Birgit Hoeger (B)

St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria.
Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria.

Özlem Yüce Petronczki (Ö)

St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria.
Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria.

Sevgi Köstel Bal (SK)

St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria.
Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria.

Samaneh Zoghi (S)

St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria.
Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria.

Jasmin Dmytrus (J)

St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria.
Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria.

Davide Seruggia (D)

St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria.

Irinka Castanon (I)

St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria.

Nima Rezaei (N)

Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran.

Markku Varjosalo (M)

Institute of Biotechnology, Helsinki Institute of Life Science, Proteomics Unit, University of Helsinki, Helsinki, Finland.

Florian Halbritter (F)

St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria.

Sergio D Rosenzweig (SD)

Immunology Service, Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20814, USA.

Kaan Boztug (K)

St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria.
Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria.
CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria.
St. Anna Children's Hospital, Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria.

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