Loss-of-function mutation in

Adult Aged Female Germinal Center / immunology Humans Ikaros Transcription Factor / blood Male Middle Aged Mucosal-Associated Invariant T Cells / immunology Young Adult

Journal

Science immunology
ISSN: 2470-9468
Titre abrégé: Sci Immunol
Pays: United States
ID NLM: 101688624

Informations de publication

Date de publication:
26 Nov 2021
Historique:
entrez: 26 11 2021
pubmed: 27 11 2021
medline: 8 3 2022
Statut: ppublish

Résumé

The Ikaros family transcription factors regulate lymphocyte development. Loss-of-function variants in

Identifiants

DOI: 10.1126/sciimmunol.abe3454 PMID: 34826260
pubmed: 34826260
doi: 10.1126/sciimmunol.abe3454
doi:

Substances chimiques

IKZF2 protein, human 0
Ikaros Transcription Factor 148971-36-2

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

eabe3454

Auteurs

Iivo Hetemäki (I)

Translational Immunology Research Program, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
ORCID: 0000-0002-6576-3549

Meri Kaustio (M)

Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.
ORCID: 0000-0002-3547-8843

Matias Kinnunen (M)

Institute of Biotechnology, HiLIFE Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.
ORCID: 0000-0002-5659-0316

Nelli Heikkilä (N)

Translational Immunology Research Program, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
ORCID: 0000-0002-8879-1569

Salla Keskitalo (S)

Institute of Biotechnology, HiLIFE Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.
ORCID: 0000-0001-5555-1975

Kirsten Nowlan (K)

Translational Immunology Research Program, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
ORCID: 0000-0002-8713-4823

Simo Miettinen (S)

Translational Immunology Research Program, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Joona Sarkkinen (J)

Translational Immunology Research Program, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
ORCID: 0000-0002-5963-0379

Virpi Glumoff (V)

Research Unit of Biomedicine, University of Oulu, Oulu, Finland.
ORCID: 0000-0003-3461-6471

Noora Andersson (N)

Department of Pathology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
ORCID: 0000-0003-4708-7273

Kaisa Kettunen (K)

Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.
Department of Clinical Genetics and HUSLAB Laboratory of Genetics, Helsinki University Hospital, Helsinki, Finland.
ORCID: 0000-0001-7402-461X

Reetta Vanhanen (R)

Translational Immunology Research Program, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Katariina Nurmi (K)

Translational Immunology Research Program, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
ORCID: 0000-0001-5406-5334

Kari K Eklund (KK)

Translational Immunology Research Program, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Department of Rheumatology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Orton Orthopaedic Hospital of the Orton Foundation, Helsinki, Finland.
ORCID: 0000-0002-5870-4663

Johannes Dunkel (J)

Department of Pathology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
ORCID: 0000-0002-8576-8160

Mikko I Mäyränpää (MI)

Department of Pathology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
ORCID: 0000-0002-0877-9640

Heinrich Schlums (H)

Center for Hematology and Regenerative Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.
ORCID: 0000-0002-2895-7766

T Petteri Arstila (TP)

Translational Immunology Research Program, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Kai Kisand (K)

Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.
ORCID: 0000-0002-5426-4648

Yenan T Bryceson (YT)

Center for Hematology and Regenerative Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.
Broegelmann Research Laboratory, Department of Clinical Sciences, University of Bergen, Bergen, Norway.
ORCID: 0000-0002-7783-9934

Pärt Peterson (P)

Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.
ORCID: 0000-0001-6755-791X

Ulla Otava (U)

Infectious Disease Unit, Department of Internal Medicine, Tampere University Hospital, Tampere, Finland.
ORCID: 0000-0002-8772-628X

Jaana Syrjänen (J)

Infectious Disease Unit, Department of Internal Medicine, Tampere University Hospital, Tampere, Finland.

Janna Saarela (J)

Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.
Department of Clinical Genetics and HUSLAB Laboratory of Genetics, Helsinki University Hospital, Helsinki, Finland.
Centre for Molecular Medicine Norway (NCMM), University of Oslo, Oslo, Norway.
Department of Medical Genetics, Oslo University Hospital, Oslo, Norway.
ORCID: 0000-0002-0853-6219

Markku Varjosalo (M)

Institute of Biotechnology, HiLIFE Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.
ORCID: 0000-0002-1340-9732

Eliisa Kekäläinen (E)

Translational Immunology Research Program, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
ORCID: 0000-0001-6045-108X

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Loss-of-function mutation in
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Loss-of-function mutation in
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Système lymphatique › Tissu lymphoïde › Noeuds lymphatiques › Centre germinatif › Loss-of-function mutation in
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Loss-of-function mutation in
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription Krüppel-like › Facteur de transcription Ikaros › Loss-of-function mutation in
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Loss-of-function mutation in
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Cellules T invariantes associées aux muqueuses › Loss-of-function mutation in
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Jeune adulte › Loss-of-function mutation in