Pharmacokinetics, bioavailability and withdrawal period of antibiotic oxytetracycline in catfish Pangasianodon hypophthalmus.
Oral
Pangasius
Parenteral
Pharmacokinetics
Tetracycline
Journal
Environmental toxicology and pharmacology
ISSN: 1872-7077
Titre abrégé: Environ Toxicol Pharmacol
Pays: Netherlands
ID NLM: 9612020
Informations de publication
Date de publication:
Jan 2022
Jan 2022
Historique:
received:
22
06
2021
revised:
15
11
2021
accepted:
17
11
2021
pubmed:
27
11
2021
medline:
9
2
2022
entrez:
26
11
2021
Statut:
ppublish
Résumé
The antibiotic oxytetracycline (OTC) has been widely used for therapeutic and preventive management of bacterial diseases in finfish and shellfish. In the present study the bioavailability, pharmacokinetics, and withdrawal period of the OTC have been determined following in-feed administration in intensively cultured catfish Pangasianodon hypophthalmus. Furthermore, the pharmacokinetic parameters of oral route were also compared with parenteral route. Drug concentrations were measured in various tissues at different time intervals by LC-MS/MS. The study revealed the drug kinetics best followed the enterohepatic circulation model with very poor bioavailability and low blood concentration after oral administration. In the withdrawal study, after 10-days of in-feed administration at the therapeutic dose the drug reached very high concentrations in the liver and kidneys but did not attain minimum inhibitory concentrations (MICs) in blood or flesh. OTC concentration also did not exceed the recommended MRL value in flesh; however, considering high amounts of the chemical in the liver and kidneys a withdrawal period of 4 days (at 28 ± 1.5
Identifiants
pubmed: 34826611
pii: S1382-6689(21)00196-4
doi: 10.1016/j.etap.2021.103778
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Oxytetracycline
X20I9EN955
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
103778Informations de copyright
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