An Exploratory Study on Resting-State Functional Connectivity in Individuals with Disorganized Attachment: Evidence for Key Regions in Amygdala and Hippocampus.
adult attachment
fMRI
organized attachment
resting-state functional connectivity
unresolved attachment
Journal
Brain sciences
ISSN: 2076-3425
Titre abrégé: Brain Sci
Pays: Switzerland
ID NLM: 101598646
Informations de publication
Date de publication:
19 Nov 2021
19 Nov 2021
Historique:
received:
30
09
2021
revised:
08
11
2021
accepted:
17
11
2021
entrez:
27
11
2021
pubmed:
28
11
2021
medline:
28
11
2021
Statut:
epublish
Résumé
Studies comparing organized (O) and unresolved/disorganized (UD) attachment have consistently shown structural and functional brain abnormalities, although whether and how attachment patterns may affect resting state functional connectivity (RSFC) is still little characterized. Here, we investigated RSFC of temporal and limbic regions of interest for UD attachment. Participants' attachment was classified via the Adult Attachment Interview, and all participants underwent clinical assessment. Functional magnetic resonance imaging data were collected from 11 UD individuals and seven matched O participants during rest. A seed-to-voxel analysis was performed, including the anterior and the posterior cingulate cortex, the bilateral insula, amygdala and hippocampus as seed regions. No group differences in the clinical scales emerged. Compared to O, the UD group showed lower RSFC between the left amygdala and the left cerebellum (lobules VIII), and lower functional coupling between the right hippocampus and the posterior portion of the right middle temporal gyrus. Moreover, UD participants showed higher RSFC between the right amygdala and the anterior cingulate cortex. Our findings suggest RSFC alterations in regions associated with encoding of salient events, emotion processing, memories retrieval and self-referential processing in UD participants, highlighting the potential role of attachment experiences in shaping brain abnormalities also in non-clinical UD individuals.
Identifiants
pubmed: 34827538
pii: brainsci11111539
doi: 10.3390/brainsci11111539
pmc: PMC8615787
pii:
doi:
Types de publication
Journal Article
Langues
eng
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
Proc Natl Acad Sci U S A. 2013 Nov 5;110(45):18274-8
pubmed: 24145410
J Neurosci. 1999 Dec 15;19(24):10869-76
pubmed: 10594068
J Child Adolesc Ment Health. 2005 Oct;17(2):83-4
pubmed: 25871354
Brain Imaging Behav. 2016 Mar;10(1):226-37
pubmed: 25913645
PLoS One. 2012;7(10):e46970
pubmed: 23056545
Psychiatry Res. 2013 Apr 30;206(2-3):273-81
pubmed: 23123044
Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5335-40
pubmed: 9560276
Acta Neuropsychiatr. 2012 Feb;24(1):4-15
pubmed: 28183380
Dev Sci. 2012 Jul;15(4):516-27
pubmed: 22709401
Drug Alcohol Depend. 2016 Apr 1;161:163-70
pubmed: 26880595
J Trauma Stress. 2019 Oct;32(5):742-752
pubmed: 31361352
Neuroimage. 2015 Oct 1;119:210-20
pubmed: 26142270
PLoS One. 2009 Jun 10;4(6):e5865
pubmed: 19517024
Hum Brain Mapp. 2014 Apr;35(4):1154-66
pubmed: 23408420
Trends Neurosci. 2010 Jun;33(6):277-84
pubmed: 20226543
Hippocampus. 2010 Aug;20(8):922-35
pubmed: 19739247
Dev Cogn Neurosci. 2019 Dec;40:100724
pubmed: 31726318
Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):19119-24
pubmed: 24191026
J Neurophysiol. 2003 Sep;90(3):1877-86
pubmed: 12702705
Hum Brain Mapp. 2014 Sep;35(9):4815-26
pubmed: 24737710
Neuropsychologia. 1997 Nov;35(11):1437-44
pubmed: 9352521
Front Hum Neurosci. 2016 Aug 02;10:389
pubmed: 27531977
Psychopathology. 2006;39(3):144-52
pubmed: 16531690
J Pers Disord. 2020 Dec;34(6):764-784
pubmed: 30785838
Biol Psychiatry. 2015 Feb 15;77(4):314-23
pubmed: 24993057
Neuroimage. 2010 Feb 15;49(4):3057-64
pubmed: 19944173
Arch Gen Psychiatry. 2009 Mar;66(3):275-85
pubmed: 19255377
Biol Psychiatry. 2010 Feb 15;67(4):357-64
pubmed: 20015483
Soc Neurosci. 2013;8(4):314-25
pubmed: 23706064
J Cogn Neurosci. 2017 Apr;29(4):718-727
pubmed: 27897675
Dev Psychopathol. 2005 Winter;17(1):47-65
pubmed: 15971759
Am J Psychiatry. 2000 Apr;157(4):493-505
pubmed: 10739407
Curr Opin Neurobiol. 2010 Apr;20(2):221-30
pubmed: 20299204
Neuroimage. 2014 Aug 15;97:236-44
pubmed: 24736182
Proc Natl Acad Sci U S A. 2019 Aug 20;116(34):16787-16792
pubmed: 31383763
Brain. 1998 Apr;121 ( Pt 4):561-79
pubmed: 9577385
Soc Neurosci. 2014;9(4):352-63
pubmed: 24635646
Cogn Neurosci. 2016 Jan-Oct;7(1-4):203-22
pubmed: 26505808
J Affect Disord. 2021 May 1;286:78-79
pubmed: 33714173
Neurosci Biobehav Rev. 2021 Aug;127:334-352
pubmed: 33964307
Sci Rep. 2020 Jun 15;10(1):9658
pubmed: 32541672
Biol Psychiatry. 2010 Jun 15;67(12):1137-45
pubmed: 20163787
Neuropsychol Rev. 2010 Sep;20(3):236-60
pubmed: 20821056
Trends Cogn Sci. 2011 Feb;15(2):85-93
pubmed: 21167765
Science. 1998 May 1;280(5364):747-9
pubmed: 9563953
Attach Hum Dev. 2009 May;11(3):223-63
pubmed: 19455453
J Affect Disord. 2017 Oct 15;221:47-55
pubmed: 28628767
Dev Sci. 2012 May;15(3):307-19
pubmed: 22490172
Brain Cogn. 2004 Nov;56(2):129-40
pubmed: 15518930
Depress Anxiety. 2012 Nov;29(11):939-47
pubmed: 22628125
Brain Connect. 2012;2(3):125-41
pubmed: 22642651
Neuroimage. 2006 Jul 1;31(3):968-80
pubmed: 16530430
Neuroimage. 2020 Jul 1;214:116751
pubmed: 32194284
Curr Biol. 2020 Sep 21;30(18):3672-3679.e4
pubmed: 32735813
Psychol Med. 2012 Sep;42(9):1879-90
pubmed: 22153017
Eur J Psychotraumatol. 2019 Mar 14;10(1):1583525
pubmed: 30891161
J Nerv Ment Dis. 2019 Feb;207(2):112-120
pubmed: 30688832
Neuroimage. 2011 Aug 1;57(3):1221-33
pubmed: 21609772
Psychiatr Clin North Am. 2000 Mar;23(1):103-22, vii-viii
pubmed: 10729934
Trends Cogn Sci. 2004 Mar;8(3):102-7
pubmed: 15301749
Trends Cogn Sci. 2000 Jun;4(6):215-222
pubmed: 10827444
Neuroimage. 2006 May 15;31(1):440-57
pubmed: 16466680
Brain Behav. 2014;4(6):867-76
pubmed: 25365801
Neuroimage. 2011 Jan 1;54(1):528-40
pubmed: 20728547
Handb Clin Neurol. 2018;154:235-249
pubmed: 29903442
Neuroimage. 2012 Jul 16;61(4):1213-25
pubmed: 22525876
Biol Psychiatry. 2006 Mar 1;59(5):424-9
pubmed: 16256956
J Comp Neurol. 1995 Dec 25;363(4):615-641
pubmed: 8847421
Behav Brain Res. 2016 Jul 15;308:83-93
pubmed: 27060720
Hum Brain Mapp. 2013 Nov;34(11):2899-909
pubmed: 22696400
Am J Psychiatry. 2007 Oct;164(10):1476-88
pubmed: 17898336
Nature. 1999 Nov 11;402(6758):179-81
pubmed: 10647008
Acta Psychiatr Scand. 2008 Oct;118(4):281-90
pubmed: 18759808
Dev Psychopathol. 2009 Fall;21(4):1311-34
pubmed: 19825270
J Neurosci. 2008 Jun 11;28(24):6211-9
pubmed: 18550763
Monogr Soc Res Child Dev. 1994;59(2-3):228-49
pubmed: 7984163
Top Cogn Sci. 2019 Jan;11(1):119-135
pubmed: 29131512
Proc Natl Acad Sci U S A. 2011 Aug 23;108(34):14324-9
pubmed: 21844357
Cortex. 2020 Nov;132:404-422
pubmed: 33045520
Psychol Med. 2013 Sep;43(9):1825-36
pubmed: 23254143
Attach Hum Dev. 2014;16(3):242-60
pubmed: 24417266
J Neurosci. 2020 Oct 28;40(44):8491-8500
pubmed: 33020217
Dev Psychopathol. 2015 Nov;27(4 Pt 2):1577-89
pubmed: 26535945
J Child Adolesc Psychopharmacol. 2003 Spring;13(1):65-73
pubmed: 12804127
Neuroimage. 2012 Feb 1;59(3):2142-54
pubmed: 22019881
Behav Res Ther. 2021 Nov;146:103963
pubmed: 34530318
Front Hum Neurosci. 2018 Oct 04;12:346
pubmed: 30337862
Front Mol Neurosci. 2015 Nov 16;8:68
pubmed: 26635521
Exp Neurol. 1974 Nov;45(2):268-87
pubmed: 4422320
Neuroimage. 2009 Mar 1;45(1):169-80
pubmed: 19027077
Am J Psychiatry. 2001 Sep;158(9):1423-8
pubmed: 11532726
Cereb Cortex. 2008 Apr;18(4):796-805
pubmed: 17652463
Borderline Personal Disord Emot Dysregul. 2014 Oct 28;1:15
pubmed: 26401299
Biol Psychiatry. 2003 Dec 1;54(11):1284-93
pubmed: 14643096
PLoS One. 2011 May 04;6(5):e18712
pubmed: 21573231