Genetic and Metabolic Determinants of Atrial Fibrillation in a General Population Sample: The CHRIS Study.
Cooperative Health Research in South Tyrol
GWAS
atrial fibrillation
familial aggregation
metabolomics
rare alleles
Journal
Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414
Informations de publication
Date de publication:
09 11 2021
09 11 2021
Historique:
received:
15
10
2021
revised:
29
10
2021
accepted:
01
11
2021
entrez:
27
11
2021
pubmed:
28
11
2021
medline:
13
1
2022
Statut:
epublish
Résumé
Atrial fibrillation (AF) is a supraventricular arrhythmia deriving from uncoordinated electrical activation with considerable associated morbidity and mortality. To expand the limited understanding of AF biological mechanisms, we performed two screenings, investigating the genetic and metabolic determinants of AF in the Cooperative Health Research in South Tyrol study. We found 110 AF cases out of 10,509 general population individuals. A genome-wide association scan (GWAS) identified two novel loci (
Identifiants
pubmed: 34827661
pii: biom11111663
doi: 10.3390/biom11111663
pmc: PMC8615508
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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