Nanostring-Based Identification of the Gene Expression Profile in Trigger Finger Samples.
Nanostring
gene expression
pain
trigger finger
Journal
Healthcare (Basel, Switzerland)
ISSN: 2227-9032
Titre abrégé: Healthcare (Basel)
Pays: Switzerland
ID NLM: 101666525
Informations de publication
Date de publication:
20 Nov 2021
20 Nov 2021
Historique:
received:
12
08
2021
revised:
26
10
2021
accepted:
05
11
2021
entrez:
27
11
2021
pubmed:
28
11
2021
medline:
28
11
2021
Statut:
epublish
Résumé
Trigger finger is a common yet vastly understudied fibroproliferative hand pathology, severely affecting patients' quality of life. Consistent trauma due to inadequate positioning within the afflicted finger's tendon/pulley system leads to cellular dysregulation and eventual fibrosis. While the genetic characteristics of the fibrotic tissue in the trigger finger have been studied, the pathways that govern the initiation and propagation of fibrosis are still unknown. The complete gene expression profile of the trigger finger has never been explored. Our study has used the Nanostring nCounter gene expression assay to investigate the molecular signaling involved in trigger finger pathogenesis. We collected samples from patients undergoing trigger finger (
Identifiants
pubmed: 34828637
pii: healthcare9111592
doi: 10.3390/healthcare9111592
pmc: PMC8619339
pii:
doi:
Types de publication
Journal Article
Langues
eng
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