Much Ado about Sleep: Current Concepts on Mechanisms and Predisposition to Pediatric Obstructive Sleep Apnea.
adenotonsillar hypertrophy
craniofacial
critical pressure
inflammatory cytokines
mechanisms
neuromuscular control
pediatric obstructive sleep apnea
starling resistor model
upper airway
Journal
Children (Basel, Switzerland)
ISSN: 2227-9067
Titre abrégé: Children (Basel)
Pays: Switzerland
ID NLM: 101648936
Informations de publication
Date de publication:
11 Nov 2021
11 Nov 2021
Historique:
received:
23
09
2021
revised:
11
10
2021
accepted:
18
10
2021
entrez:
27
11
2021
pubmed:
28
11
2021
medline:
28
11
2021
Statut:
epublish
Résumé
Obstructive Sleep Apnea (OSA) is a form of sleep-disordered breathing characterized by upper airway collapse during sleep resulting in recurring arousals and desaturations. However, many aspects of this syndrome in children remain unclear. Understanding underlying pathogenic mechanisms of OSA is critical for the development of therapeutic strategies. In this article, we review current concepts surrounding the mechanism, pathogenesis, and predisposing factors of pediatric OSA. Specifically, we discuss the biomechanical properties of the upper airway that contribute to its primary role in OSA pathogenesis and examine the anatomical and neuromuscular factors that predispose to upper airway narrowing and collapsibility.
Identifiants
pubmed: 34828745
pii: children8111032
doi: 10.3390/children8111032
pmc: PMC8623682
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Références
Thorax. 2017 Aug;72(8):694-701
pubmed: 28082529
Nat Sci Sleep. 2013 Sep 25;5:109-23
pubmed: 24109201
Laryngoscope. 2021 Mar;131(3):E1022-E1028
pubmed: 32818314
Arch Pediatr Adolesc Med. 2005 Aug;159(8):775-85
pubmed: 16061787
Curr Opin Allergy Clin Immunol. 2010 Feb;10(1):26-33
pubmed: 19996963
Acta Otorhinolaryngol Ital. 2019 Oct;39(5):289-297
pubmed: 31708576
Am J Respir Crit Care Med. 1999 Jan;159(1):149-57
pubmed: 9872833
Bosn J Basic Med Sci. 2017 Feb 21;17(1):47-53
pubmed: 27754829
Medicine (Baltimore). 2016 Oct;95(41):e4944
pubmed: 27741107
Sleep Med. 2019 Mar;55:109-114
pubmed: 30780114
Front Med (Lausanne). 2017 Sep 28;4:161
pubmed: 29034238
J Pediatr. 2011 Jan;158(1):77-82
pubmed: 20846669
Ann Am Thorac Soc. 2021 Aug 4;:
pubmed: 34347573
Int J Environ Res Public Health. 2019 Sep 04;16(18):
pubmed: 31487798
J Appl Physiol (1985). 2014 Dec 15;117(12):1478-85
pubmed: 25324514
J Laryngol Otol. 2009 Feb;123(2):203-7
pubmed: 18549514
Eur J Paediatr Dent. 2019 Mar;20(1):43-47
pubmed: 30919644
Chest. 2017 Feb;151(2):500-506
pubmed: 27720883
Laryngoscope. 2017 May;127(5):1224-1230
pubmed: 27411973
Sleep Med. 2016 Nov - Dec;27-28:99-106
pubmed: 27938928
J Appl Physiol (1985). 1988 Feb;64(2):535-42
pubmed: 3372411
Proc Am Thorac Soc. 2008 Feb 15;5(2):274-82
pubmed: 18250221
Sleep. 2018 Jan 1;41(1):
pubmed: 29228393
J Appl Physiol (1985). 1994 Aug;77(2):918-24
pubmed: 8002548
Plast Reconstr Surg. 2017 Nov;140(5):987-997
pubmed: 29068938
Sleep. 2019 Jun 11;42(6):
pubmed: 30794310
Sleep Med. 2018 Aug;48:70-78
pubmed: 29860189
Sleep Med Rev. 2018 Aug;40:203-214
pubmed: 29103943
J Appl Physiol Respir Environ Exerc Physiol. 1978 Jun;44(6):931-8
pubmed: 670014
Chest. 2008 Mar;133(3):684-9
pubmed: 18198258
Eur Rev Med Pharmacol Sci. 2019 Mar;23(1 Suppl):9-14
pubmed: 30920636
Sleep Med Rev. 2018 Feb;37:45-59
pubmed: 28110857
Mediators Inflamm. 2014;2014:605280
pubmed: 24991089
J Otolaryngol Head Neck Surg. 2020 Mar 4;49(1):11
pubmed: 32131901
J Physiol. 2013 May 1;591(9):2229-32
pubmed: 23740879
Chest. 1996 Oct;110(4):1077-88
pubmed: 8874271
J Am Coll Cardiol. 2017 Feb 21;69(7):841-858
pubmed: 28209226
Am J Respir Crit Care Med. 2011 Mar 15;183(6):782-7
pubmed: 20935105
Paediatr Respir Rev. 2017 Sep;24:21-23
pubmed: 28697968
Paediatr Respir Rev. 2019 Nov;32:48-54
pubmed: 31076378
Mediators Inflamm. 2014;2014:146893
pubmed: 25276051
Sleep Sci. 2017 Jan-Mar;10(1):1-6
pubmed: 28966731
Neurology. 2007 Jul 17;69(3):243-9
pubmed: 17636061
Sleep. 2021 Feb 12;44(2):
pubmed: 32835382
Adv Otorhinolaryngol. 2017;80:41-48
pubmed: 28738388
Respir Physiol Neurobiol. 2020 Mar;274:103362
pubmed: 31866501
Sleep Med Rev. 2016 Feb;25:84-94
pubmed: 26164371
Pediatr Ann. 2017 Sep 1;46(9):e336-e339
pubmed: 28892549
Sleep Breath. 2015 Dec;19(4):1257-64
pubmed: 25877805
Nat Sci Sleep. 2018 Sep 06;10:271-286
pubmed: 30233265
Cleve Clin J Med. 2019 Sep;86(9 Suppl 1):2-9
pubmed: 31509498
Eur Respir J. 2016 Jan;47(1):69-94
pubmed: 26541535
J Paediatr Child Health. 2016 Mar;52(3):284-90
pubmed: 26748912
Sleep Med. 2021 May;81:336-340
pubmed: 33765650
J Paediatr Child Health. 2006 May;42(5):277-82
pubmed: 16712558
Int J Pediatr Otorhinolaryngol. 2016 Nov;90:5-11
pubmed: 27729152
Sleep. 2016 Mar 01;39(3):511-21
pubmed: 26612386
J Clin Sleep Med. 2014 May 15;10(5):559-66
pubmed: 24812542
Clin Otolaryngol. 2014 Oct;39(5):266-71
pubmed: 25099745
Nat Sci Sleep. 2018 Jan 23;10:21-34
pubmed: 29416383
Proc Am Thorac Soc. 2008 Feb 15;5(2):253-62
pubmed: 18250219
Chest. 2002 May;121(5):1531-40
pubmed: 12006440
Gen Dent. 2018 Nov-Dec;66(6):46-50
pubmed: 30444706
Sleep Med Clin. 2019 Mar;14(1):13-20
pubmed: 30709527
Sleep. 2021 Aug 25;:
pubmed: 34432065
Sleep. 2019 Dec 24;42(12):
pubmed: 31581285
J Dent Sci. 2020 Jun;15(2):193-199
pubmed: 32595901
Dentomaxillofac Radiol. 2016;45(7):20160136
pubmed: 27440304
Am Fam Physician. 2014 Mar 1;89(5):368-77
pubmed: 24695508
Anesth Analg. 2017 Jan;124(1):179-191
pubmed: 27861433
Adv Otorhinolaryngol. 2017;80:136-144
pubmed: 28738322
J Pediatr. 1989 Jun;114(6):997-9
pubmed: 2723918
Sleep. 2011 Apr 01;34(4):459-67
pubmed: 21461324
J Clin Med. 2020 Apr 05;9(4):
pubmed: 32260590
Am J Otolaryngol. 2018 May - Jun;39(3):327-337
pubmed: 29525140
Pediatrics. 2012 Sep;130(3):e714-55
pubmed: 22926176
Pediatrics. 2007 Oct;120(4):e1028-34
pubmed: 17908723
Lung. 2020 Apr;198(2):257-270
pubmed: 32166426
Am J Respir Crit Care Med. 1998 Apr;157(4 Pt 1):1204-12
pubmed: 9563740
Sleep Med Clin. 2019 Mar;14(1):135-142
pubmed: 30709528
Sleep Med. 2007 Dec;9(1):3-8
pubmed: 17638593
J Craniofac Surg. 2021 Mar-Apr 01;32(2):564-568
pubmed: 33704981
Pediatrics. 2004 Jun;113(6):e564-9
pubmed: 15173538
Eur Arch Otorhinolaryngol. 2018 Dec;275(12):2983-2990
pubmed: 30317385
J Thorac Dis. 2015 Aug;7(8):1358-72
pubmed: 26380762
Sleep Med Clin. 2018 Dec;13(4):531-548
pubmed: 30396447
Int J Pediatr Otorhinolaryngol. 2002 Aug 1;65(1):7-13
pubmed: 12127217
Arch Cardiovasc Dis. 2020 May;113(5):350-358
pubmed: 32224049
Pediatr Res. 2005 Jan;57(1):99-107
pubmed: 15557113
Sleep Med. 2008 Mar;9(3):254-9
pubmed: 17825619
J Allergy Clin Immunol. 1997 Feb;99(2):S757-62
pubmed: 9042068