From Immune Dysregulations to Therapeutic Perspectives in Myelodysplastic Syndromes: A Review.
T-cell
immune
inflammation
myelodysplastic syndromes
Journal
Diagnostics (Basel, Switzerland)
ISSN: 2075-4418
Titre abrégé: Diagnostics (Basel)
Pays: Switzerland
ID NLM: 101658402
Informations de publication
Date de publication:
26 Oct 2021
26 Oct 2021
Historique:
received:
30
09
2021
revised:
21
10
2021
accepted:
22
10
2021
entrez:
27
11
2021
pubmed:
28
11
2021
medline:
28
11
2021
Statut:
epublish
Résumé
The pathophysiology of myelodysplastic syndromes (MDSs) is complex and often includes immune dysregulation of both the innate and adaptive immune systems. Whereas clonal selection mainly involves smoldering inflammation, a cellular immunity dysfunction leads to increased apoptosis and blast proliferation. Addressing immune dysregulations in MDS is a recent concept that has allowed the identification of new therapeutic targets. Several approaches targeting the different actors of the immune system have therefore been developed. However, the results are very heterogeneous, indicating the need to improve our understanding of the disease and interactions between chronic inflammation, adaptive dysfunction, and somatic mutations. This review highlights current knowledge of the role of immune dysregulation in MDS pathophysiology and the field of new drugs.
Identifiants
pubmed: 34829329
pii: diagnostics11111982
doi: 10.3390/diagnostics11111982
pmc: PMC8620222
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Références
J Clin Oncol. 2011 Jan 20;29(3):303-9
pubmed: 21149672
Blood. 2011 Oct 6;118(14):3765-76
pubmed: 21753188
Leuk Lymphoma. 2019 Nov;60(11):2733-2743
pubmed: 31046498
Leukemia. 2020 Jun;34(6):1512-1523
pubmed: 32313108
Front Oncol. 2020 Aug 07;10:1595
pubmed: 32903786
Cancer Cell. 2013 Jul 8;24(1):90-104
pubmed: 23845443
J Immunol. 2011 May 1;186(9):5367-75
pubmed: 21441445
Front Immunol. 2021 Apr 27;12:665541
pubmed: 33986753
J Immunol. 2012 Sep 15;189(6):3198-208
pubmed: 22875800
Pathol Oncol Res. 2000;6(1):18-23
pubmed: 10749583
Blood. 2007 Aug 1;110(3):847-50
pubmed: 17412885
Blood Adv. 2018 Jul 24;2(14):1765-1772
pubmed: 30037803
Leukemia. 2017 Jun;31(6):1286-1295
pubmed: 27881874
Nat Rev Cancer. 2011 Oct 24;11(11):805-12
pubmed: 22020206
N Engl J Med. 2014 Dec 25;371(26):2477-87
pubmed: 25426838
Blood Cancer J. 2019 Nov 12;9(11):86
pubmed: 31719523
Haematologica. 2013 Aug;98(8):1206-15
pubmed: 23403315
Med Oncol. 2017 Aug 30;34(10):168
pubmed: 28856536
Leukemia. 2013 Sep;27(9):1832-40
pubmed: 23765228
Blood. 2009 Jun 25;113(26):6541-8
pubmed: 19389880
Br J Haematol. 2012 Feb;156(3):409-12
pubmed: 25289412
Oncotarget. 2017 Oct 4;8(51):88904-88917
pubmed: 29179486
Cell. 2013 Jun 6;153(6):1194-217
pubmed: 23746838
Exp Cell Res. 2016 Jan 1;340(1):22-31
pubmed: 26708616
Br J Pharmacol. 2012 Dec;167(7):1415-30
pubmed: 22774848
Mediators Inflamm. 2021 Jul 9;2021:9913382
pubmed: 34335093
N Engl J Med. 2020 Oct 1;383(14):1358-1374
pubmed: 32997910
Blood. 2017 Oct 12;130(15):1713-1721
pubmed: 28830889
Leukemia. 2017 Mar;31(3):697-704
pubmed: 27654852
Blood. 2018 Oct 11;132(15):1553-1560
pubmed: 30104218
Haematologica. 2013 Nov;98(11):1778-87
pubmed: 23894012
Clin Immunol. 2011 Jun;139(3):350-9
pubmed: 21444247
Blood. 2002 Nov 15;100(10):3639-45
pubmed: 12393644
Leuk Res. 2016 Dec;51:49-55
pubmed: 27846431
Nat Cell Biol. 2019 May;21(5):640-650
pubmed: 31011167
Haematologica. 2015 May;100(5):643-52
pubmed: 25682594
PLoS One. 2013 Aug 15;8(8):e71120
pubmed: 23976989
Autoimmun Rev. 2017 Sep;16(9):903-910
pubmed: 28705782
Haematologica. 2011 Mar;96(3):432-40
pubmed: 21134985
Eur J Haematol. 2014 Nov;93(5):429-38
pubmed: 24813620
Clin Hematol Int. 2020 Jun;2(2):43-48
pubmed: 32879911
Blood. 2020 Dec 10;136(24):2812-2823
pubmed: 32730593
Cancer Immun. 2013 May 01;13:8
pubmed: 23833565
Immunol Rev. 2017 Mar;276(1):145-164
pubmed: 28258703
J Cell Mol Med. 2020 Jan;24(1):1046-1058
pubmed: 31756785
Leukemia. 2012 Apr;26(4):693-9
pubmed: 21912394
Blood. 2021 Jul 1;137(26):3682-3684
pubmed: 33619558
Blood. 2016 Dec 15;128(24):2819-2823
pubmed: 27760759
N Engl J Med. 2020 Dec 31;383(27):2628-2638
pubmed: 33108101
J Clin Oncol. 2003 May 15;21(10):1988-95
pubmed: 12743153
Cell Rep. 2016 Dec 6;17(10):2584-2595
pubmed: 27926863
Blood. 2019 Mar 7;133(10):1039-1048
pubmed: 30670444
Blood Adv. 2021 Mar 9;5(5):1565-1575
pubmed: 33687432
Hematology Am Soc Hematol Educ Program. 2012;2012:56-64
pubmed: 23233561
Leuk Res. 2014 Jun;38(6):714-21
pubmed: 24746294
Blood Adv. 2021 Aug 24;5(16):3203-3215
pubmed: 34427584
Front Oncol. 2020 Jan 22;9:1380
pubmed: 32038992
Br J Dermatol. 2021 Oct 10;:
pubmed: 34632574
Leukemia. 2009 Mar;23(3):510-8
pubmed: 19020538
Leukemia. 2014 Jun;28(6):1280-8
pubmed: 24270737
Nature. 2016 Jul 06;535(7610):153-8
pubmed: 27383986
Leuk Res. 2013 May;37(5):541-6
pubmed: 23453286
Clin Lymphoma Myeloma Leuk. 2018 Oct;18(10):658-663.e2
pubmed: 30001986
Br J Haematol. 2010 Mar;148(6):944-7
pubmed: 20064151
Leukemia. 2019 Aug;33(8):2034-2046
pubmed: 30737486
Leukemia. 2004 Sep;18(9):1451-6
pubmed: 15284864
Cytokine. 2019 Jan;113:462-465
pubmed: 29958797
Dtsch Arztebl Int. 2016 May 6;113(18):317-22
pubmed: 27215596
Cancer. 2019 May 1;125(9):1470-1481
pubmed: 30500073
Exp Hematol. 2019 Jun;74:52-63.e3
pubmed: 31136781
Br J Haematol. 2021 Nov;195(3):378-387
pubmed: 34340254
Clin Cancer Res. 2007 Feb 15;13(4):1154-60
pubmed: 17317824
Br J Haematol. 2021 Oct 14;:
pubmed: 34651299
Leuk Lymphoma. 2018 Apr;59(4):790-802
pubmed: 28679300
Nat Rev Microbiol. 2009 Feb;7(2):99-109
pubmed: 19148178
Leuk Lymphoma. 1997 May;25(5-6):435-43
pubmed: 9250813
Front Immunol. 2018 Apr 09;9:586
pubmed: 29686666
Front Immunol. 2020 Jun 17;11:1236
pubmed: 32625214
Crit Rev Oncol Hematol. 2016 Nov;107:90-99
pubmed: 27823655
Front Immunol. 2018 May 01;9:947
pubmed: 29770138
Blood. 2015 Nov 19;126(21):2355-61
pubmed: 26429975
Leuk Res. 2013 Aug;37(8):907-10
pubmed: 23642736
J Geriatr Oncol. 2021 Sep;12(7):1122-1129
pubmed: 33771514
Blood. 2012 Sep 20;120(12):2454-65
pubmed: 22740453
Science. 2017 Feb 24;355(6327):842-847
pubmed: 28104796
Leuk Res. 2007 Oct;31(10):1373-82
pubmed: 17188353
Blood. 2007 Jun 1;109(11):4816-24
pubmed: 17341666
Immunity. 2006 Jun;24(6):801-812
pubmed: 16782035
Br J Haematol. 2021 Jun;193(5):941-945
pubmed: 33954988
Haematologica. 2019 Sep;104(9):e388-e392
pubmed: 30846499
Nat Commun. 2021 Jan 12;12(1):338
pubmed: 33436578
Nature. 2011 Sep 11;478(7367):64-9
pubmed: 21909114
Eur J Haematol. 2005 Dec;75(6):485-91
pubmed: 16313260
Am J Hematol. 2011 Nov;86(11):918-22
pubmed: 21898529
Nat Genet. 2013 Oct;45(10):1232-7
pubmed: 23955599
Clin Cancer Res. 2018 Aug 1;24(15):3519-3527
pubmed: 29716921
Leuk Res. 2021 Nov;110:106713
pubmed: 34619434
J Clin Invest. 2013 Nov;123(11):4595-611
pubmed: 24216507
J Immunol Res. 2016;2016:5479013
pubmed: 28074192
Am J Hematol. 2020 Nov;95(11):1399-1420
pubmed: 32744763
Nat Med. 2020 Sep;26(9):1459-1467
pubmed: 32601337
Blood Adv. 2019 Aug 27;3(16):2482-2486
pubmed: 31434682
Crit Rev Oncol Hematol. 2018 Feb;122:123-132
pubmed: 29458780
Clin Cancer Res. 2018 Mar 1;24(5):1019-1029
pubmed: 28947565
Lancet Haematol. 2019 Sep;6(9):e480-e488
pubmed: 31400961
Blood Rev. 2019 Jul;36:57-69
pubmed: 31036385
Haematologica. 2012 Apr;97(4):529-33
pubmed: 22102701
Nature. 2015 Jul 9;523(7559):183-188
pubmed: 26131937
N Engl J Med. 2011 Jun 30;364(26):2496-506
pubmed: 21714648
J Immunol. 2020 Apr 15;204(8):2098-2109
pubmed: 32179638
Leuk Res. 1996 Nov-Dec;20(11-12):891-900
pubmed: 9009245
Leukemia. 2007 Apr;21(4):659-67
pubmed: 17301813
Leuk Res. 2013 Sep;37(9):1016-20
pubmed: 23773898
Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):E1490-E1499
pubmed: 28167789
Hum Vaccin Immunother. 2021 Aug 3;17(8):2602-2616
pubmed: 33941042
Exp Hematol. 2019 Dec;80:36-41.e3
pubmed: 31812712
Int J Hematol. 2007 Jan;85(1):11-7
pubmed: 17261496
Biol Blood Marrow Transplant. 2013 Apr;19(4):562-8
pubmed: 23266740
J Clin Med. 2021 Jun 24;10(13):
pubmed: 34202907
Leukemia. 2007 Jul;21(7):1436-41
pubmed: 17507999
Crit Rev Oncol Hematol. 2019 Jan;133:112-119
pubmed: 30661647
Nat Med. 2014 Dec;20(12):1472-8
pubmed: 25326804
Exp Hematol. 2018 Mar;59:60-65
pubmed: 29195897
PLoS Genet. 2015 Feb 06;11(2):e1004932
pubmed: 25658809
Leukemia. 2014 Feb;28(2):241-7
pubmed: 24220272
Nat Med. 2014 Apr;20(4):408-14
pubmed: 24658078
N Engl J Med. 2020 Jan 9;382(2):140-151
pubmed: 31914241
Nature. 2015 Oct 29;526(7575):660-5
pubmed: 26375003
Cytometry B Clin Cytom. 2016 Jul;90(4):349-57
pubmed: 26648320
Blood. 2013 Nov 21;122(22):3616-27; quiz 3699
pubmed: 24030381
Haematologica. 2014 Jul;99(7):1176-83
pubmed: 24488560
Blood. 2021 Jul 1;137(26):3676-3681
pubmed: 33690815
Medicine (Baltimore). 2019 May;98(22):e15844
pubmed: 31145332
PLoS One. 2013 Aug 19;8(8):e72138
pubmed: 23977231
Front Immunol. 2017 Jun 07;8:496
pubmed: 28638379
Blood Adv. 2019 Apr 9;3(7):980-983
pubmed: 30936058
Cell. 2009 Jul 23;138(2):286-99
pubmed: 19632179
PLoS One. 2021 Mar 17;16(3):e0248430
pubmed: 33730109
Blood. 2008 Jul 1;112(1):45-52
pubmed: 18443215
Am J Hematol. 2015 Jul;90(7):602-7
pubmed: 25802083
Ann Hematol. 2017 Sep;96(9):1441-1448
pubmed: 28643044
Leuk Res Rep. 2020 Jun 28;14:100215
pubmed: 32695574
Immunol Cell Biol. 2014 Mar;92(3):230-6
pubmed: 24445601
Eur J Haematol. 2013 May;90(5):375-84
pubmed: 23331180
Leuk Res. 2013 Mar;37(3):266-73
pubmed: 23153526
Br J Haematol. 2009 Apr;145(1):64-72
pubmed: 19210506
Blood. 2008 Jan 1;111(1):236-42
pubmed: 17875804
N Engl J Med. 2014 Dec 25;371(26):2488-98
pubmed: 25426837
Asia Pac J Clin Oncol. 2021 Jun 21;:
pubmed: 34152084
Exp Hematol. 2020 Aug;88:42-55
pubmed: 32652111
Blood Adv. 2018 Jun 26;2(12):1459-1469
pubmed: 29941459
Cell Rep. 2018 Dec 11;25(11):2992-3005.e5
pubmed: 30540934
Blood. 2016 Dec 22;128(25):2960-2975
pubmed: 27737891
Cancer. 2008 Oct 1;113(7):1605-13
pubmed: 18683214
Blood. 2015 Jul 2;126(1):9-16
pubmed: 25931582
Blood. 2010 Aug 19;116(7):1124-31
pubmed: 20472834
Pathobiology. 2019;86(1):24-29
pubmed: 29791902
Cell Stem Cell. 2010 Dec 3;7(6):708-17
pubmed: 21112565