Incidence, Clinical Presentation and Trends in Indication for Diagnostic Work-Up of Small Intestinal and Pancreatic Neuroendocrine Tumors.
clinical presentation
incidence
incidentaloma
small intestinal and pancreatic neuroendocrine tumors
Journal
Diagnostics (Basel, Switzerland)
ISSN: 2075-4418
Titre abrégé: Diagnostics (Basel)
Pays: Switzerland
ID NLM: 101658402
Informations de publication
Date de publication:
03 Nov 2021
03 Nov 2021
Historique:
received:
14
10
2021
revised:
26
10
2021
accepted:
28
10
2021
entrez:
27
11
2021
pubmed:
28
11
2021
medline:
28
11
2021
Statut:
epublish
Résumé
The incidence of small intestinal (SI) and pancreatic neuroendocrine tumors (siNETs and pNETs) seems to have increased. The increased frequency of incidental findings might be a possible explanation. The study aimed to examine (1) changes in incidence and the stage at diagnosis (2010-2011 vs. 2019-2020), (2) changes in the initial indication for diagnostic workup and 3) the differences in stage between incidentally discovered vs. symptomatic disease during the entire study period. We performed a retrospective study, that includes consecutive siNET and pNET patients referred to the Copenhagen ENETS center of excellence in 2010-2011 and 2019-2020. The annual incidence of siNET per 100,000 increased from 1.39 to 1.84, ( The incidence of siNET and pNETs increased over the past decade. For siNETs, the stage of disease and the distribution of symptomatic vs. incidentally discovered tumors were unchanged between the two periods. Patients with pNETs presented with more local and incidentally discovered tumors in the latter period. Patients with incidentally discovered siNETs had disseminated disease in 44% of the overall cases. The vast majority of incidentally found pNETs were localized.
Sections du résumé
BACKGROUND
BACKGROUND
The incidence of small intestinal (SI) and pancreatic neuroendocrine tumors (siNETs and pNETs) seems to have increased. The increased frequency of incidental findings might be a possible explanation. The study aimed to examine (1) changes in incidence and the stage at diagnosis (2010-2011 vs. 2019-2020), (2) changes in the initial indication for diagnostic workup and 3) the differences in stage between incidentally discovered vs. symptomatic disease during the entire study period.
METHODS
METHODS
We performed a retrospective study, that includes consecutive siNET and pNET patients referred to the Copenhagen ENETS center of excellence in 2010-2011 and 2019-2020.
RESULTS
RESULTS
The annual incidence of siNET per 100,000 increased from 1.39 to 1.84, (
CONCLUSION
CONCLUSIONS
The incidence of siNET and pNETs increased over the past decade. For siNETs, the stage of disease and the distribution of symptomatic vs. incidentally discovered tumors were unchanged between the two periods. Patients with pNETs presented with more local and incidentally discovered tumors in the latter period. Patients with incidentally discovered siNETs had disseminated disease in 44% of the overall cases. The vast majority of incidentally found pNETs were localized.
Identifiants
pubmed: 34829377
pii: diagnostics11112030
doi: 10.3390/diagnostics11112030
pmc: PMC8624499
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
Pancreas. 2010 Aug;39(6):707-12
pubmed: 20664470
Histopathology. 2020 Jan;76(2):182-188
pubmed: 31433515
J Clin Endocrinol Metab. 2013 Dec;98(12):4784-9
pubmed: 24057286
Semin Nucl Med. 2002 Apr;32(2):133-40
pubmed: 11965608
J Clin Endocrinol Metab. 2019 Dec 1;104(12):6129-6138
pubmed: 31369096
Neuroendocrinology. 2018;107(1):42-49
pubmed: 29550809
J Nucl Med. 2015 Jun;56(6):847-54
pubmed: 25952736
JAMA Oncol. 2017 Oct 1;3(10):1335-1342
pubmed: 28448665
Neuroendocrinology. 2017;104(1):1-10
pubmed: 26562558
Endocrine. 2017 Nov;58(2):368-379
pubmed: 28303513
Nucl Med Commun. 2020 Oct;41(10):1095-1099
pubmed: 32732598
Clin Med Insights Endocrinol Diabetes. 2019 Oct 24;12:1179551419884058
pubmed: 31695546
Curr Opin Gastroenterol. 2020 Jan;36(1):48-54
pubmed: 31633562
J Nucl Med. 2017 Mar;58(3):451-457
pubmed: 27660147
Cancer. 2015 Feb 15;121(4):589-97
pubmed: 25312765
J Clin Endocrinol Metab. 2021 Apr 23;106(5):e2251-e2261
pubmed: 33479747
Clin Chem. 2007 Mar;53(3):438-46
pubmed: 17259235
Br J Surg. 2017 Jan;104(1):34-41
pubmed: 27706803
Am J Gastroenterol. 2010 Jun;105(6):1421-9
pubmed: 20087335
Visc Med. 2017 Oct;33(5):324-330
pubmed: 29177160
Scand J Gastroenterol. 2014 Jun;49(6):734-41
pubmed: 24679166
Cureus. 2020 Mar 5;12(3):e7186
pubmed: 32257725
Surgery. 2012 Dec;152(6):965-74
pubmed: 23102679
J Nucl Med. 2007 Apr;48(4):508-18
pubmed: 17401086
Elife. 2014 May 27;3:e01641
pubmed: 24867636
Neuroendocrinology. 2017 Mar 30;105(3):212-244
pubmed: 28355596
Curr Oncol Rep. 2021 Mar 14;23(4):43
pubmed: 33719003