Serum Organ-Specific Anti-Heart and Anti-Intercalated Disk Autoantibodies as New Autoimmune Markers of Cardiac Involvement in Systemic Sclerosis: Frequency, Clinical and Prognostic Correlates.
autoantibodies
autoimmunity
myocarditis
prognosis
systemic sclerosis
Journal
Diagnostics (Basel, Switzerland)
ISSN: 2075-4418
Titre abrégé: Diagnostics (Basel)
Pays: Switzerland
ID NLM: 101658402
Informations de publication
Date de publication:
22 Nov 2021
22 Nov 2021
Historique:
received:
17
10
2021
revised:
09
11
2021
accepted:
17
11
2021
entrez:
27
11
2021
pubmed:
28
11
2021
medline:
28
11
2021
Statut:
epublish
Résumé
Heart involvement (HInv) in systemic sclerosis (SSc) may relate to myocarditis and is associated with poor prognosis. Serum anti-heart (AHA) and anti-intercalated disk autoantibodies (AIDA) are organ and disease-specific markers of isolated autoimmune myocarditis. We assessed frequencies, clinical correlates, and prognostic impacts of AHA and AIDA in SSc. The study included consecutive SSc patients ( The frequency of AHA was higher in SSc (57/116, 49%, The high frequencies of AHA and AIDA suggest a high burden of underdiagnosed autoimmune HInv in SSc. In keeping with the negative prognostic impact of HInv in SSc, AHAs were associated with dismal prognosis.
Sections du résumé
BACKGROUND
BACKGROUND
Heart involvement (HInv) in systemic sclerosis (SSc) may relate to myocarditis and is associated with poor prognosis. Serum anti-heart (AHA) and anti-intercalated disk autoantibodies (AIDA) are organ and disease-specific markers of isolated autoimmune myocarditis. We assessed frequencies, clinical correlates, and prognostic impacts of AHA and AIDA in SSc.
METHODS
METHODS
The study included consecutive SSc patients (
RESULTS
RESULTS
The frequency of AHA was higher in SSc (57/116, 49%,
CONCLUSIONS
CONCLUSIONS
The high frequencies of AHA and AIDA suggest a high burden of underdiagnosed autoimmune HInv in SSc. In keeping with the negative prognostic impact of HInv in SSc, AHAs were associated with dismal prognosis.
Identifiants
pubmed: 34829512
pii: diagnostics11112165
doi: 10.3390/diagnostics11112165
pmc: PMC8625508
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
Eur Heart J. 2017 Sep 14;38(35):2649-2662
pubmed: 28655210
Semin Arthritis Rheum. 2014 Feb;43(4):526-35
pubmed: 23932313
Int J Cardiol. 2015 Jan 20;179:166-77
pubmed: 25464438
Clin Exp Rheumatol. 2020 May-Jun;38 Suppl 125(3):25-28
pubmed: 32242801
Arthritis Rheum. 2013 Nov;65(11):2737-47
pubmed: 24122180
Ann Rheum Dis. 2009 Dec;68(12):1878-84
pubmed: 19054830
Am Heart J. 1993 Jan;125(1):194-203
pubmed: 8417518
Ann Rheum Dis. 2014 Dec;73(12):2087-93
pubmed: 23940211
Int J Cardiol. 2019 Apr 1;280:110-116
pubmed: 30522885
Rheumatology (Oxford). 2013 Oct;52(10):1920-1
pubmed: 23481540
Eur Heart J. 2007 Jun;28(11):1326-33
pubmed: 17493945
PLoS One. 2015 May 12;10(5):e0126707
pubmed: 25966025
Eur Heart J. 2016 Jan 1;37(1):67-119
pubmed: 26320113
Circulation. 2020 Apr 14;141(15):1238-1248
pubmed: 32114801
Circulation. 1992 May;85(5):1734-42
pubmed: 1533350
JACC Cardiovasc Imaging. 2019 May;12(5):927-928
pubmed: 30553664
Microcirculation. 2020 Nov;27(8):e12647
pubmed: 32603500
Eur J Intern Med. 2019 Feb;60:46-53
pubmed: 30366614
J Rheumatol. 2001 Jul;28(7):1573-6
pubmed: 11469464
J Clin Med. 2021 Jun 02;10(11):
pubmed: 34199661
Rheumatology (Oxford). 2020 Aug 1;59(8):1938-1948
pubmed: 31764972
JACC Clin Electrophysiol. 2020 Oct;6(10):1221-1234
pubmed: 33092747
Arthritis Rheumatol. 2015 Feb;67(2):508-16
pubmed: 25371068
J Am Coll Cardiol. 1990 Jun;15(7):1527-34
pubmed: 2188986
Rheumatology (Oxford). 2020 Sep 1;59(9):2523-2533
pubmed: 31990340
Ann Rheum Dis. 2010 Jan;69(1):218-21
pubmed: 19279015
Circulation. 2007 Jan 2;115(1):76-83
pubmed: 17179019
Eur J Immunol. 2021 Apr;51(4):893-902
pubmed: 33368288
Arthritis Rheum. 2007 Nov;56(11):3827-36
pubmed: 17968945
Best Pract Res Clin Rheumatol. 2021 Sep;35(3):101668
pubmed: 33736950
Eur Heart J. 2013 Sep;34(33):2636-48, 2648a-2648d
pubmed: 23824828