Peroxisome Proliferator-Activated Receptors (PPARs) and Oxidative Stress in Physiological Conditions and in Cancer.
cancer
inflammation
oxidative stress
peroxisome proliferator-activated receptors (PPARs)
Journal
Antioxidants (Basel, Switzerland)
ISSN: 2076-3921
Titre abrégé: Antioxidants (Basel)
Pays: Switzerland
ID NLM: 101668981
Informations de publication
Date de publication:
29 Oct 2021
29 Oct 2021
Historique:
received:
05
10
2021
revised:
25
10
2021
accepted:
26
10
2021
entrez:
27
11
2021
pubmed:
28
11
2021
medline:
28
11
2021
Statut:
epublish
Résumé
Peroxisome proliferator-activated receptors (PPARs) belong to the nuclear hormone receptor superfamily. Originally described as "orphan nuclear receptors", they can bind both natural and synthetic ligands acting as agonists or antagonists. In humans three subtypes, PPARα, β/δ, γ, are encoded by different genes, show tissue-specific expression patterns, and contribute to the regulation of lipid and carbohydrate metabolisms, of different cell functions, including proliferation, death, differentiation, and of processes, as inflammation, angiogenesis, immune response. The PPAR ability in increasing the expression of various antioxidant genes and decreasing the synthesis of pro-inflammatory mediators, makes them be considered among the most important regulators of the cellular response to oxidative stress conditions. Based on the multiplicity of physiological effects, PPAR involvement in cancer development and progression has attracted great scientific interest with the aim to describe changes occurring in their expression in cancer cells, and to investigate the correlation with some characteristics of cancer phenotype, including increased proliferation, decreased susceptibility to apoptosis, malignancy degree and onset of resistance to anticancer drugs. This review focuses on mechanisms underlying the antioxidant and anti-inflammatory properties of PPARs in physiological conditions, and on the reported beneficial effects of PPAR activation in cancer.
Identifiants
pubmed: 34829605
pii: antiox10111734
doi: 10.3390/antiox10111734
pmc: PMC8614822
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : University of Turin
ID : No grant number was assigned
Références
Toxicology. 2003 May 3;187(2-3):149-59
pubmed: 12699904
Oncotarget. 2017 Jan 31;8(5):8083-8094
pubmed: 28042952
Vascul Pharmacol. 2009 Aug-Sep;51(2-3):169-74
pubmed: 19540934
Cancer Lett. 2010 Jan 1;287(1):62-6
pubmed: 19540663
Gynecol Oncol. 2005 May;97(2):365-73
pubmed: 15863131
FASEB J. 2020 Jul;34(7):8796-8809
pubmed: 32396271
Oxid Med Cell Longev. 2019 Nov 12;2019:4826525
pubmed: 31781338
Free Radic Biol Med. 2012 May 1;52(9):1734-43
pubmed: 22387176
Life Sci. 2008 Apr 9;82(15-16):884-91
pubmed: 18346759
Int J Mol Sci. 2020 Sep 29;21(19):
pubmed: 33003644
Food Res Int. 2020 Nov;137:109706
pubmed: 33233280
PPAR Res. 2019 Jul 3;2019:7486727
pubmed: 31354797
Endocr J. 2010;57(4):303-9
pubmed: 20075562
PLoS One. 2011;6(12):e28502
pubmed: 22174823
Gastrointest Tumors. 2020 Apr;7(1-2):11-20
pubmed: 32399461
J Biol Chem. 1999 Apr 9;274(15):10505-10
pubmed: 10187842
Adv Exp Med Biol. 1991;284:97-104
pubmed: 2053496
J Cell Biochem. 2011 Feb;112(2):675-83
pubmed: 21268089
Br J Pharmacol. 2007 May;151(1):45-53
pubmed: 17351653
Cell Metab. 2007 Feb;5(2):129-42
pubmed: 17276355
Biochem Pharmacol. 2020 Oct;180:114194
pubmed: 32800851
Int J Mol Sci. 2021 Jun 15;22(12):
pubmed: 34203800
Free Radic Biol Med. 2002 Feb 1;32(3):233-45
pubmed: 11827749
Nat Struct Mol Biol. 2011 Feb;18(2):177-84
pubmed: 21240272
Nature. 2005 Sep 29;437(7059):759-63
pubmed: 16127449
Chem Biol Interact. 2016 Aug 25;256:142-53
pubmed: 27417252
J Radiat Res. 2020 Nov 16;61(6):842-850
pubmed: 32876675
Biochem Biophys Res Commun. 2019 Jul 23;515(2):352-358
pubmed: 31153636
J Clin Invest. 1997 May 15;99(10):2416-22
pubmed: 9153284
PPAR Res. 2021 Jan 9;2021:8895376
pubmed: 33505452
Drug Res (Stuttg). 2018 Jun;68(6):355-360
pubmed: 29433142
FEBS J. 2010 Mar;277(6):1543-50
pubmed: 20163460
Biochim Biophys Acta. 2014 Jan;1840(1):303-14
pubmed: 24041992
Cell Biochem Funct. 2010 Oct;28(7):571-7
pubmed: 20862655
Metabolism. 2021 Jan;114:154338
pubmed: 32791172
Arch Toxicol. 2018 Jan;92(1):83-119
pubmed: 29197930
PeerJ. 2020 Nov 18;8:e10182
pubmed: 33240601
Mol Cell. 2003 Nov;12(5):1137-49
pubmed: 14636573
Oncotarget. 2016 Oct 18;7(42):69075-69086
pubmed: 27626166
Endocr Rev. 1999 Oct;20(5):649-88
pubmed: 10529898
Hypertension. 2010 Jun;55(6):1444-53
pubmed: 20404217
J Biol Chem. 2000 Nov 24;275(47):36703-7
pubmed: 10980195
Syst Biol Reprod Med. 2021 Feb;67(1):24-41
pubmed: 33719831
PLoS Genet. 2013;9(7):e1003626
pubmed: 23874225
Toxicol Appl Pharmacol. 2007 Dec 15;225(3):267-77
pubmed: 17950772
Mutat Res. 2000 Mar 17;448(2):121-38
pubmed: 10725467
Theranostics. 2021 Jan 1;11(5):2424-2441
pubmed: 33500734
PPAR Res. 2017;2017:7058424
pubmed: 28167956
Gene Expr. 1996;6(3):185-95
pubmed: 9041124
PLoS One. 2013 Jun 24;8(6):e66947
pubmed: 23826177
Am J Physiol Gastrointest Liver Physiol. 2010 Dec;299(6):G1211-21
pubmed: 20930048
Biofactors. 2021 Sep;47(5):778-787
pubmed: 34089284
Am J Respir Crit Care Med. 2010 Jul 15;182(2):170-82
pubmed: 20224069
J Oncol. 2009;2009:867915
pubmed: 19841681
Oncol Lett. 2018 May;15(5):6727-6732
pubmed: 29731858
J Biol Chem. 2006 Oct 27;281(43):32164-74
pubmed: 16943204
Jpn J Clin Oncol. 2002 Jul;32(7):238-43
pubmed: 12324573
World J Gastroenterol. 2015 Dec 7;21(45):12787-99
pubmed: 26668503
Int J Cancer. 2004 Dec 20;112(6):909-19
pubmed: 15316938
Int J Mol Sci. 2020 Aug 10;21(16):
pubmed: 32785018
Mediators Inflamm. 2019 Oct 21;2019:1769374
pubmed: 31772499
Free Radic Biol Med. 2016 Oct;99:63-70
pubmed: 27480845
Free Radic Biol Med. 2007 Jun 1;42(11):1661-70
pubmed: 17462534
Am J Physiol Heart Circ Physiol. 2012 Feb 1;302(3):H515-26
pubmed: 22037188
Genes Cells. 2004 Nov;9(11):1017-29
pubmed: 15507114
PLoS One. 2015 Apr 27;10(4):e0125171
pubmed: 25915942
J Dermatol Sci. 2021 Sep;103(3):167-175
pubmed: 34420848
Mol Pharmacol. 2003 Aug;64(2):355-64
pubmed: 12869640
Science. 1999 Nov 12;286(5443):1368-71
pubmed: 10558993
Life Sci. 2019 Dec 15;239:117047
pubmed: 31730865
Genes Dev. 2006 Jun 1;20(11):1405-28
pubmed: 16751179
Eur J Med Chem. 2017 Dec 1;141:162-168
pubmed: 29031063
J Mol Neurosci. 2016 Aug;59(4):544-53
pubmed: 27339772
Physiol Res. 2016 Oct 24;65(Suppl 3):S343-S363
pubmed: 27775420
J Cell Physiol. 2019 Aug;234(8):13252-13262
pubmed: 30580435
Diabetes. 1997 Aug;46(8):1319-27
pubmed: 9231657
Biochem Biophys Res Commun. 1999 May 10;258(2):278-83
pubmed: 10329378
World J Gastroenterol. 2005 Sep 28;11(36):5621-6
pubmed: 16237754
Inflammation. 2016 Apr;39(2):611-24
pubmed: 26597893
Chem Biol Interact. 2018 Aug 25;292:9-14
pubmed: 29986832
EXCLI J. 2021 May 26;20:956-967
pubmed: 34267608
Mol Med Rep. 2015 Aug;12(2):2239-46
pubmed: 25891367
Nat Commun. 2019 Dec 20;10(1):5825
pubmed: 31862968
Fundam Clin Pharmacol. 2017 Dec;31(6):652-662
pubmed: 28636803
ACS Omega. 2020 Mar 04;5(10):5334-5339
pubmed: 32201822
Int J Cancer. 2007 Dec 1;121(11):2395-401
pubmed: 17691108
Cancer Res. 2008 Aug 15;68(16):6578-86
pubmed: 18701481
Chem Biol Interact. 2003 Feb 1;143-144:29-35
pubmed: 12604186
PPAR Res. 2010;2010:
pubmed: 20814439
Biochem Biophys Res Commun. 2000 Jul 5;273(2):560-4
pubmed: 10873645
PPAR Res. 2017;2017:5879090
pubmed: 28298922
J Biol Chem. 2000 Oct 20;275(42):32681-7
pubmed: 10934192
Cytokine. 2007 Sep;39(3):184-91
pubmed: 17822917
PLoS One. 2009 Aug 27;4(8):e6796
pubmed: 19710929
Cancers (Basel). 2010 Apr 13;2(2):483-97
pubmed: 24281078
Endocrinology. 2009 Feb;150(2):1000-13
pubmed: 18845641
Toxicol Ind Health. 2016 May;32(5):801-8
pubmed: 24311629
Cancer Res. 2000 Sep 1;60(17):4798-803
pubmed: 10987289
J Biol Chem. 2001 Nov 30;276(48):44495-501
pubmed: 11577087
Expert Opin Ther Pat. 2020 Jan;30(1):1-13
pubmed: 31825687
J Neurochem. 2015 Oct;135(1):139-46
pubmed: 26119485
Sci Rep. 2016 Aug 18;6:31649
pubmed: 27535180
PLoS One. 2012;7(1):e30772
pubmed: 22292036
Immunobiology. 2011 Jun;216(6):715-24
pubmed: 21176858
J Biol Chem. 2007 Apr 20;282(16):11776-85
pubmed: 17324937
Trends Immunol. 2007 Dec;28(12):551-8
pubmed: 17981503
Genome Med. 2016 Jul 11;8(1):74
pubmed: 27401066
Nature. 1998 Sep 10;395(6698):199-202
pubmed: 9744281
Int J Med Sci. 2021 Jan 1;18(1):256-269
pubmed: 33390794
Int J Mol Sci. 2018 Jun 12;19(6):
pubmed: 29895749
Toxicol Sci. 2009 Mar;108(1):48-58
pubmed: 19103650
Biochem J. 2001 Aug 1;357(Pt 3):811-8
pubmed: 11463352
J Cell Physiol. 2012 Jan;227(1):239-49
pubmed: 21412771
Front Biosci (Landmark Ed). 2014 Jun 01;19:916-35
pubmed: 24896326
J Biol Chem. 2004 Jul 9;279(28):29551-7
pubmed: 15123625
J Inflamm Res. 2021 Feb 24;14:461-477
pubmed: 33658824
J Biol Chem. 1999 Nov 5;274(45):32048-54
pubmed: 10542237
Mol Aspects Med. 1993;14(3):217-28
pubmed: 8264336
J Biol Chem. 2016 Nov 25;291(48):25179-25191
pubmed: 27738106
J Biol Chem. 1997 Mar 21;272(12):8071-6
pubmed: 9065481
Biochem Biophys Res Commun. 2006 Dec 22;351(3):733-8
pubmed: 17084382
J Cell Biochem. 2003 Nov 1;90(4):732-44
pubmed: 14587029
J Biol Chem. 1999 Jan 29;274(5):2672-81
pubmed: 9915797
Cells. 2019 Jul 30;8(8):
pubmed: 31366145
Nat Rev Mol Cell Biol. 2003 Mar;4(3):192-201
pubmed: 12612638
Crit Rev Eukaryot Gene Expr. 2020;30(2):93-100
pubmed: 32558488
Mol Endocrinol. 2002 Dec;16(12):2793-801
pubmed: 12456800
Wei Sheng Yan Jiu. 2017 Sep;46(5):802-806
pubmed: 29903312
Free Radic Biol Med. 2012 Aug 15;53(4):758-68
pubmed: 22684020
Mol Pharmacol. 2000 Oct;58(4):788-94
pubmed: 10999949
Biochem Biophys Res Commun. 1999 Oct 22;264(2):311-5
pubmed: 10529360
Biochem Pharmacol. 2007 Jul 15;74(2):298-308
pubmed: 17499220
Am J Respir Crit Care Med. 2008 Jun 1;177(11):1223-32
pubmed: 18356564
Antioxid Redox Signal. 2011 Oct 15;15(8):2335-81
pubmed: 21194351
Cardiovasc Res. 2007 Nov 1;76(2):269-79
pubmed: 17678635
Cell Signal. 2016 Mar;28(3):158-164
pubmed: 26721185
J Biol Chem. 2009 May 15;284(20):13291-5
pubmed: 19182219
J Biol Chem. 2010 Feb 26;285(9):5983-92
pubmed: 19955185
Gastroenterology. 2009 Apr;136(4):1242-50
pubmed: 19186181
J Biol Chem. 1999 Oct 15;274(42):29874-82
pubmed: 10514468
Environ Toxicol. 2021 Dec;36(12):2541-2550
pubmed: 34499403
Anticancer Res. 2012 Aug;32(8):3479-83
pubmed: 22843934
Methods Mol Biol. 2013;952:1-6
pubmed: 23100221
Trends Endocrinol Metab. 2015 Nov;26(11):595-607
pubmed: 26490384
Curr Mol Med. 2011 Jun;11(4):304-16
pubmed: 21506921
Biochim Biophys Acta. 2007 Aug;1771(8):972-82
pubmed: 17631413
Oncogene. 2003 May 29;22(22):3412-6
pubmed: 12776192
Cell Rep. 2014 Apr 10;7(1):223-35
pubmed: 24703845
Pflugers Arch. 2010 Apr;459(5):689-703
pubmed: 20066433
Phytother Res. 2021 Jun;35(6):3298-3309
pubmed: 33570219
Oncogene. 2007 Aug 13;26(37):5439-49
pubmed: 17694085
Free Radic Biol Med. 2012 Feb 15;52(4):735-46
pubmed: 22206977
Cell Death Dis. 2020 Oct 13;11(10):848
pubmed: 33051435
Cell Metab. 2014 Oct 7;20(4):650-61
pubmed: 25264247
Front Pharmacol. 2021 Jun 14;12:658362
pubmed: 34194324
Toxicol Sci. 2021 Aug 30;183(1):81-92
pubmed: 34081146
Biomed Pharmacother. 2020 Sep;129:110356
pubmed: 32535388
J Clin Invest. 2009 Oct;119(10):3138-48
pubmed: 19729835
J Biol Chem. 2007 Jul 13;282(28):20621-33
pubmed: 17430897
Biomed Res Int. 2015;2015:642520
pubmed: 26301250
J Biol Chem. 1997 Oct 10;272(41):25500-6
pubmed: 9325263
PLoS One. 2012;7(9):e46009
pubmed: 23049921
Biochem Biophys Res Commun. 2017 May 6;486(3):726-731
pubmed: 28342874
Obes Res. 2004 Jun;12(6):921-8
pubmed: 15229330
Free Radic Biol Med. 2006 Jun 1;40(11):1929-38
pubmed: 16716894
Photochem Photobiol. 2015 Nov;91(6):1458-68
pubmed: 26303058
Immunity. 2006 May;24(5):601-10
pubmed: 16713977
Exp Ther Med. 2020 Aug;20(2):1003-1011
pubmed: 32765656
Diabetologia. 2005 Jun;48(6):1180-8
pubmed: 15887043
J Immunol. 2011 Jul 15;187(2):702-7
pubmed: 21670314
J Biol Chem. 2002 Oct 4;277(40):37254-9
pubmed: 12118000
Int J Cardiol. 2013 Jul 31;167(2):409-15
pubmed: 22277574
Chem Biol Interact. 2014 Dec 5;224:164-75
pubmed: 25452175
Scand J Gastroenterol. 2011 Mar;46(3):358-69
pubmed: 20969493
Cancer Res. 2004 May 15;64(10):3701-13
pubmed: 15150131
Cell Biochem Funct. 1989 Jan;7(1):11-9
pubmed: 2752533
Cell. 2017 Oct 5;171(2):372-384.e12
pubmed: 28942920
Cancer Res. 2007 Jun 1;67(11):5285-92
pubmed: 17545608
Biochimie. 2014 Mar;98:63-74
pubmed: 24291192
Mol Pharmacol. 1998 Jan;53(1):14-22
pubmed: 9443928
Neuropharmacology. 2014 Apr;79:298-306
pubmed: 24262633
J Clin Invest. 2017 Apr 3;127(4):1202-1214
pubmed: 28368286
Am J Pathol. 2010 Oct;177(4):1697-709
pubmed: 20709802
Glia. 2010 Apr;58(5):588-98
pubmed: 19908287
Eur J Pharmacol. 2020 Aug 15;881:173230
pubmed: 32553810
Carcinogenesis. 1994 Jul;15(7):1359-64
pubmed: 8033312
Chin Med J (Engl). 2007 Sep 5;120(17):1498-504
pubmed: 17908458
Cancer Res. 2018 Jan 15;78(2):399-409
pubmed: 29187400
Mol Cell Biochem. 2006 Jun;286(1-2):33-42
pubmed: 16534556
Biochem Pharmacol. 2016 Jun 15;110-111:25-36
pubmed: 27179975
PPAR Res. 2012;2012:269751
pubmed: 22619672
Inflamm Res. 2008 Jul;57(7):314-21
pubmed: 18622687
Free Radic Biol Med. 2018 Oct;126:350-357
pubmed: 30118830
Trends Biochem Sci. 2009 Apr;34(4):176-88
pubmed: 19321346
Int J Mol Med. 2005 Sep;16(3):483-92
pubmed: 16077959
Mol Cell Biol. 2005 Jul;25(14):6065-76
pubmed: 15988019
Front Immunol. 2021 Feb 26;12:630569
pubmed: 33717162
Iran J Basic Med Sci. 2019 Aug;22(8):940-948
pubmed: 31579451
J Biol Chem. 2013 Jan 18;288(3):1726-38
pubmed: 23168409
Mol Cell Biol. 2004 Jun;24(11):4651-63
pubmed: 15143161
Oxid Med Cell Longev. 2017;2017:1378175
pubmed: 28928902