The Impact of N-Acetyl Cysteine and Coenzyme Q10 Supplementation on Skeletal Muscle Antioxidants and Proteome in Fit Thoroughbred Horses.
antioxidants
glycolysis
mitochondria
mitochondrial proteins
reactive oxygen species
redox
Journal
Antioxidants (Basel, Switzerland)
ISSN: 2076-3921
Titre abrégé: Antioxidants (Basel)
Pays: Switzerland
ID NLM: 101668981
Informations de publication
Date de publication:
30 Oct 2021
30 Oct 2021
Historique:
received:
10
09
2021
revised:
26
10
2021
accepted:
28
10
2021
entrez:
27
11
2021
pubmed:
28
11
2021
medline:
28
11
2021
Statut:
epublish
Résumé
Horses have one of the highest skeletal muscle oxidative capacities amongst mammals, which, combined with a high glycolytic capacity, could perturb redox status during maximal exercise. We determined the effect of 30 d of oral coenzyme Q10 and N-acetyl-cysteine supplementation (NACQ) on muscle glutathione (GSH), cysteine, ROS, and coenzyme Q10 concentrations, and the muscle proteome, in seven maximally exercising Thoroughbred horses using a placebo and randomized cross-over design. Gluteal muscle biopsies were obtained the day before and 1 h after maximal exercise. Concentrations of GSH, cysteine, coenzyme Q10, and ROS were measured, and citrate synthase, glutathione peroxidase, and superoxide dismutase activities analyzed. GSH increased significantly 1 h post-exercise in the NACQ group (
Identifiants
pubmed: 34829610
pii: antiox10111739
doi: 10.3390/antiox10111739
pmc: PMC8615093
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : McPhail Equine Endowment, Michigan State University
ID : N/A
Organisme : Kentucky Equine Research, Versailles, KY
ID : N/A
Organisme : Martha Wolfson Endowment, Michigan State University
ID : N/A
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