Glutathione Peroxidase in Stable Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-analysis.
antioxidant defense systems
chronic obstructive pulmonary disease
glutathione peroxidase
oxidative stress
Journal
Antioxidants (Basel, Switzerland)
ISSN: 2076-3921
Titre abrégé: Antioxidants (Basel)
Pays: Switzerland
ID NLM: 101668981
Informations de publication
Date de publication:
30 Oct 2021
30 Oct 2021
Historique:
received:
13
09
2021
revised:
22
10
2021
accepted:
28
10
2021
entrez:
27
11
2021
pubmed:
28
11
2021
medline:
28
11
2021
Statut:
epublish
Résumé
Chronic obstructive pulmonary disease (COPD) is a progressive disease that is characterized by a state of persistent inflammation and oxidative stress. The presence of oxidative stress in COPD is the result of an imbalance between pro-oxidant and antioxidant mechanisms. The aim of this review was to investigate a possible association between glutathione peroxidase (GPx), a key component of antioxidant defense mechanisms, and COPD. A systematic search for relevant studies was conducted in the electronic databases PubMed, Web of Science, Scopus, and Google Scholar, from inception to June 2021. Standardized mean differences (SMDs) were used to express the differences in GPx concentrations between COPD patients and non-COPD subjects. Twenty-four studies were identified. In 15 studies assessing whole blood/erythrocytes (GPx isoform 1), the pooled results showed that GPx concentrations were significantly lower in patients with COPD (SMD = -1.91, 95% CI -2.55 to -1.28,
Identifiants
pubmed: 34829616
pii: antiox10111745
doi: 10.3390/antiox10111745
pmc: PMC8615188
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Sardinian Fondo di Sviluppo e Coesione (FSC) 2014 - 2020, Patto per lo Sviluppo della Regione Sardegna, L.R.7-2017
ID : RASSR82005
Organisme : Fondo di Ateneo per la Ricerca
ID : annualità 2020
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