Significance of Sex Differences in ncRNAs Expression and Function in Pregnancy and Related Complications.
embryo
fetal sex
gestational diabetes
miRNA
ncRNA
placenta
preeclampsia
pregnancy complications
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
20 Oct 2021
20 Oct 2021
Historique:
received:
05
07
2021
revised:
01
10
2021
accepted:
08
10
2021
entrez:
27
11
2021
pubmed:
28
11
2021
medline:
28
11
2021
Statut:
epublish
Résumé
In the era of personalized medicine, fetal sex-specific research is of utmost importance for comprehending the mechanisms governing pregnancy and pregnancy-related complications. In recent times, noncoding RNAs (ncRNAs) have gained increasing attention as critical players in gene regulation and disease pathogenesis, and as candidate biomarkers in human diseases as well. Different types of ncRNAs, including microRNAs (miRNAs), piwi-interacting RNAs (piRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs), participate in every step of pregnancy progression, although studies taking into consideration fetal sex as a central variable are still limited. To date, most of the available data have been obtained investigating sex-specific placental miRNA expression. Several studies revealed that miRNAs regulate the (patho)-physiological processes in a sexually dimorphic manner, ensuring normal fetal development, successful pregnancy, and susceptibility to diseases. Moreover, the observation that ncRNA profiles differ according to cells, tissues, and developmental stages of pregnancy, along with the complex interactions among different types of ncRNAs in regulating gene expression, strongly indicates that more studies are needed to understand the role of sex-specific ncRNA in pregnancy and associated disorders.
Identifiants
pubmed: 34829737
pii: biomedicines9111509
doi: 10.3390/biomedicines9111509
pmc: PMC8614665
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Références
Int J Mol Sci. 2018 Jun 27;19(7):
pubmed: 29954144
Hypertension. 2020 Mar;75(3):762-771
pubmed: 31983308
Int J Mol Sci. 2021 Feb 27;22(5):
pubmed: 33673453
Clin Sci (Lond). 2020 Jan 17;134(1):39-51
pubmed: 31825070
Am J Reprod Immunol. 2015 Mar;73(3):251-62
pubmed: 25091957
Ther Clin Risk Manag. 2014 Mar 03;10:151-63
pubmed: 24623979
Epigenomics. 2020 Sep;12(17):1543-1558
pubmed: 32901510
Transcription. 2014;5(4):e944014
pubmed: 25483404
Cancers (Basel). 2021 May 29;13(11):
pubmed: 34072348
Trends Genet. 2021 Feb;37(2):188-200
pubmed: 32951946
Endocr Connect. 2021 Feb;10(2):191-204
pubmed: 33475530
Int J Mol Sci. 2021 Jan 19;22(2):
pubmed: 33477832
Sci Rep. 2020 Jun 10;10(1):9399
pubmed: 32523064
Open Biol. 2019 Dec;9(12):190213
pubmed: 31795917
Front Physiol. 2019 Jun 06;10:699
pubmed: 31263422
Exp Ther Med. 2019 Jul;18(1):826-832
pubmed: 31281456
Biosci Rep. 2020 Nov 27;40(11):
pubmed: 33146699
Exp Ther Med. 2021 Jan;21(1):8
pubmed: 33235617
Int J Mol Sci. 2020 May 21;21(10):
pubmed: 32455665
Int J Mol Sci. 2021 Mar 19;22(6):
pubmed: 33808559
Nutrients. 2019 Apr 20;11(4):
pubmed: 31010060
Cells. 2021 Jan 15;10(1):
pubmed: 33467738
Int J Obes (Lond). 2020 Jul;44(7):1497-1507
pubmed: 31852997
Biol Sex Differ. 2021 Jan 6;12(1):6
pubmed: 33407895
Fertil Steril. 2013 Mar 1;99(3):855-861.e3
pubmed: 23211712
Int J Mol Sci. 2020 Jun 04;21(11):
pubmed: 32512799
Mol Med Rep. 2018 Apr;17(4):4941-4952
pubmed: 29393376
Front Oncol. 2019 Sep 24;9:920
pubmed: 31608229
Cell Rep. 2015 Oct 27;13(4):854-863
pubmed: 26489470
Stem Cells. 2020 Oct 1;38(10):1216-1228
pubmed: 32598085
BMC Genomics. 2021 Apr 20;22(1):286
pubmed: 33879051
Biol Rev Camb Philos Soc. 2019 Apr;94(2):415-438
pubmed: 30151880
Placenta. 2020 Jul;96:19-26
pubmed: 32421529
Int J Obes (Lond). 2015 Aug;39(8):1274-81
pubmed: 25833255
Noncoding RNA Res. 2020 Dec;5(4):178-184
pubmed: 32959025
Pediatr Res. 2021 Apr;89(5):1157-1163
pubmed: 32663836
EBioMedicine. 2020 Dec;62:103145
pubmed: 33260001
EBioMedicine. 2021 Mar;65:103253
pubmed: 33639402
Cell Mol Life Sci. 2018 Feb;75(3):467-484
pubmed: 28840253
Mol Metab. 2018 Sep;15:8-19
pubmed: 29773464
Biol Sex Differ. 2020 May 11;11(1):26
pubmed: 32393396
Open Med (Wars). 2020 Oct 14;15(1):1061-1071
pubmed: 33336062
Front Cell Dev Biol. 2020 May 27;8:389
pubmed: 32528957
Protein Cell. 2020 Nov 1;:
pubmed: 33131025
Adv Exp Med Biol. 2018;1068:19-32
pubmed: 29943293
Rep Biochem Mol Biol. 2019 Apr;8(1):25-31
pubmed: 31334284
Nutrients. 2021 Mar 22;13(3):
pubmed: 33809891
Front Mol Biosci. 2021 Apr 20;8:652250
pubmed: 33959635
Placenta. 2021 Jan 1;103:232-241
pubmed: 33202359
Noncoding RNA Res. 2020 Apr 18;5(2):67-70
pubmed: 32346661
Biol Res. 2021 Apr 20;54(1):14
pubmed: 33879262
Front Endocrinol (Lausanne). 2018 Aug 03;9:402
pubmed: 30123182
Appl Clin Genet. 2020 Jan 08;13:1-11
pubmed: 32021379
Sci Rep. 2020 Nov 4;10(1):19046
pubmed: 33149201
Biochim Biophys Acta. 2016 Jan;1859(1):82-92
pubmed: 26348412
J Assist Reprod Genet. 2019 Feb;36(2):179-187
pubmed: 30315515
Int J Mol Sci. 2020 Apr 10;21(7):
pubmed: 32290086
Int J Mol Sci. 2020 Dec 10;21(24):
pubmed: 33321810
Biochim Biophys Acta Mol Cell Res. 2021 Jan;1868(1):118837
pubmed: 32882261
Neuroscience. 2017 Feb 7;342:4-20
pubmed: 26232714
J Diabetes Complications. 2021 Jan;35(1):107749
pubmed: 33189541
PeerJ. 2021 Apr 20;9:e11299
pubmed: 33976984
Dis Markers. 2019 May 2;2019:7237495
pubmed: 31191755
Curr Genomics. 2015 Oct;16(5):319-26
pubmed: 27047252
Nat Rev Mol Cell Biol. 2019 Jan;20(1):21-37
pubmed: 30108335
BMC Genomics. 2014 Jul 01;15:545
pubmed: 24981367
Front Pediatr. 2019 Feb 07;7:22
pubmed: 30792973
Placenta. 2010 Mar;31 Suppl:S33-9
pubmed: 20004469
Cells. 2019 Dec 04;8(12):
pubmed: 31817143
Sci Rep. 2020 Nov 2;10(1):18810
pubmed: 33139809
J Epidemiol Community Health. 2004 Feb;58(2):114-5
pubmed: 14729887
Mol Cell Endocrinol. 2018 Feb 5;461:12-21
pubmed: 28807878
J Transl Med. 2018 Sep 12;16(1):254
pubmed: 30208911
Int J Cardiol. 2019 Sep 15;291:158-167
pubmed: 31151766
BMC Genomics. 2014 Oct 27;15:941
pubmed: 25348288
Diagnostics (Basel). 2021 Mar 08;11(3):
pubmed: 33800458
BMC Mol Cell Biol. 2021 Mar 3;22(1):15
pubmed: 33657992
Life Sci. 2021 Apr 1;270:119121
pubmed: 33516697
PLoS Genet. 2015 May 14;11(5):e1005247
pubmed: 25973973
Birth Defects Res A Clin Mol Teratol. 2011 Aug;91(8):737-43
pubmed: 21425434
Int J Mol Sci. 2020 Sep 17;21(18):
pubmed: 32957662
Sci Rep. 2017 Jul 17;7(1):5548
pubmed: 28717128
Noncoding RNA. 2021 Feb 24;7(1):
pubmed: 33668203
PLoS One. 2020 Aug 13;15(8):e0236805
pubmed: 32790689
Diabetologia. 2021 Jul;64(7):1516-1526
pubmed: 33755745
Sci Rep. 2021 Aug 3;11(1):15743
pubmed: 34344912
Epigenetics. 2021 Apr;16(4):373-388
pubmed: 32892695
Nat Rev Genet. 2019 Nov;20(11):675-691
pubmed: 31395983
BMC Pregnancy Childbirth. 2020 Jun 8;20(1):348
pubmed: 32513208
Int J Mol Sci. 2020 Feb 13;21(4):
pubmed: 32070041
Cell Physiol Biochem. 2018;46(6):2576-2586
pubmed: 29758559
Int J Mol Sci. 2021 Feb 25;22(5):
pubmed: 33669156
Transl Neurodegener. 2021 Mar 8;10(1):9
pubmed: 33685517
Front Endocrinol (Lausanne). 2020 Mar 31;11:169
pubmed: 32296392
Int J Mol Sci. 2020 May 20;21(10):
pubmed: 32443673
Hum Mol Genet. 2020 Jan 15;29(2):335-350
pubmed: 31868881
Sci Rep. 2020 Sep 29;10(1):15942
pubmed: 32994523
Clin Sci (Lond). 2018 Nov 21;132(22):2437-2449
pubmed: 30389858
Endocrinology. 2015 Oct;156(10):3422-34
pubmed: 26241064
Clin Sci (Lond). 2020 Apr 30;134(8):1001-1025
pubmed: 32337535