Evaluation of Macular Retinal Vessels and Histological Changes in Two Cases of COVID-19.
ACE2
COVID-19
SARS-CoV-2
macula
microglia
retina
tortuosity
vasculature
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
26 Oct 2021
26 Oct 2021
Historique:
received:
14
09
2021
revised:
21
10
2021
accepted:
24
10
2021
entrez:
27
11
2021
pubmed:
28
11
2021
medline:
28
11
2021
Statut:
epublish
Résumé
The purpose of this study was to assess vascular and histological alterations in two COVID-19 and three control post-mortem retinas. The macular areas of flat-mounted samples were processed for immunofluorescence. Lectin and collagen IV positive vessels were captured under confocal microscopy, and endothelium loss and tortuosity were analyzed. Expression of ACE2 (angiotensin-converting enzyme 2) (the receptor for SARS-CoV-2), Iba1 (ionized calcium-binding adaptor molecule 1) and GFAP (glial fibrillary acidic protein) were quantified in retinal sections. The number of lectin vessels in COVID-19 retinas decreased by 27% compared to the control (
Identifiants
pubmed: 34829775
pii: biomedicines9111546
doi: 10.3390/biomedicines9111546
pmc: PMC8615149
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Instituto de Salud Carlos III/European Regional Development Fund (ERDF)
Organisme : OFTARED: Enfermedades oculares: "Prevención, detección precoz, tratamiento y rehabilitación de las patologías oculares
ID : RD16/0008/0011
Organisme : Fundación Jesús de Gangoiti Barrera
Organisme : Fundación Multiópticas CUN 2019
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