Macrophages and Iron: A Special Relationship.
ferroptosis
iron
macrophage
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
30 Oct 2021
30 Oct 2021
Historique:
received:
30
09
2021
revised:
21
10
2021
accepted:
28
10
2021
entrez:
27
11
2021
pubmed:
28
11
2021
medline:
28
11
2021
Statut:
epublish
Résumé
Macrophages perform a variety of different biological functions and are known for their essential role in the immune response. In this context, a principal function is phagocytic clearance of pathogens, apoptotic and senescent cells. However, the major targets of homeostatic phagocytosis by macrophages are old/damaged red blood cells. As such, macrophages play a crucial role in iron trafficking, as they recycle the large quantity of iron obtained by hemoglobin degradation. They also seem particularly adapted to handle and store amounts of iron that would be toxic to other cell types. Here, we examine the specific and peculiar iron metabolism of macrophages.
Identifiants
pubmed: 34829813
pii: biomedicines9111585
doi: 10.3390/biomedicines9111585
pmc: PMC8615895
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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