Impact of the Innate Inflammatory Response on ICU Admission and Death in Hospitalized Patients with COVID-19.
COVID-19
ICU
SARS-CoV-2
cytokines
innate inflammatory response
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
12 Nov 2021
12 Nov 2021
Historique:
received:
29
09
2021
revised:
29
10
2021
accepted:
10
11
2021
entrez:
27
11
2021
pubmed:
28
11
2021
medline:
28
11
2021
Statut:
epublish
Résumé
To describe the capacity of a broad spectrum of cytokines and growth factors to predict ICU admission and/or death in patients with severe COVID-19. An observational, analytical, retrospective cohort study with longitudinal follow-up. Hospital Universitario Príncipe de Asturias (HUPA). 287 patients diagnosed with COVID-19 admitted to our hospital from 24 March to 8 May 2020, followed until 31 August 2020. Profiles of immune response (IR) mediators were determined using the Luminex Multiplex technique in hospitalized patients within six days of admission by examining serum levels of 62 soluble molecules classified into the three groups: adaptive IR-related cytokines ( A statistically robust link with ICU admission and/or death was detected for increased serum levels of interleukin (IL)-6, IL-15, soluble (s) RAGE, IP10, MCP3, sIL1RII, IL-8, GCSF and MCSF and IL-10. The greatest prognostic value was observed for the marker combination IL-10, IL-6 and GCSF. When severe COVID-19 progresses to ICU admission and/or death there is a marked increase in serum levels of several cytokines and chemokines, mainly related to the patient's inflammatory IR. Serum levels of IL-10, IL-6 and GCSF were most prognostic of the outcome measure.
Identifiants
pubmed: 34829906
pii: biomedicines9111675
doi: 10.3390/biomedicines9111675
pmc: PMC8615389
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : ProA Capital and Startlite Foundation
ID : 03/2020
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