Steroid-Functionalized Imidazolium Salts with an Extended Spectrum of Antifungal and Antibacterial Activity.
Anti-Bacterial Agents
/ chemical synthesis
Antifungal Agents
/ chemical synthesis
Bacteria
/ drug effects
Cell Line
Cell Survival
/ drug effects
Fungi
/ drug effects
Hemolysis
/ drug effects
Humans
Imidazoles
/ chemical synthesis
Mycoses
/ drug therapy
Salts
/ chemical synthesis
Steroids
/ chemical synthesis
antibacterial activity
antifungal activity
imidazolium salts
steroid
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
10 Nov 2021
10 Nov 2021
Historique:
received:
30
09
2021
revised:
03
11
2021
accepted:
08
11
2021
entrez:
27
11
2021
pubmed:
28
11
2021
medline:
20
1
2022
Statut:
epublish
Résumé
It is established that high rates of morbidity and mortality caused by fungal infections are related to the current limited number of antifungal drugs and the toxicity of these agents. Imidazolium salts as azole derivatives can be successfully used in the treatment of fungal infections in humans. Steroid-functionalized imidazolium salts were synthesized using a new, more efficient method. As a result, 20 salts were obtained with high yields, 12 of which were synthesized and characterized for the first time. They were derivatives of lithocholic acid and 3-oxo-23,24-dinorchol-4-ene-22-al and were fully characterized by
Identifiants
pubmed: 34830061
pii: ijms222212180
doi: 10.3390/ijms222212180
pmc: PMC8623970
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Antifungal Agents
0
Imidazoles
0
Salts
0
Steroids
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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