The Role of Nucleocytoplasmic Transport Defects in Amyotrophic Lateral Sclerosis.
ALS
motor neuron
neurodegeneration
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
10 Nov 2021
10 Nov 2021
Historique:
received:
19
08
2021
revised:
10
10
2021
accepted:
14
10
2021
entrez:
27
11
2021
pubmed:
28
11
2021
medline:
20
1
2022
Statut:
epublish
Résumé
There is ample evidence that nucleocytoplasmic-transport deficits could play an important role in the pathology of amyotrophic lateral sclerosis (ALS). However, the currently available data are often circumstantial and do not fully clarify the exact causal and temporal role of nucleocytoplasmic transport deficits in ALS patients. Gaining this knowledge will be of great significance in order to be able to target therapeutically nucleocytoplasmic transport and/or the proteins involved in this process. The availability of good model systems to study the nucleocytoplasmic transport process in detail will be especially crucial in investigating the effect of different mutations, as well as of other forms of stress. In this review, we discuss the evidence for the involvement of nucleocytoplasmic transport defects in ALS and the methods used to obtain these data. In addition, we provide an overview of the therapeutic strategies which could potentially counteract these defects.
Identifiants
pubmed: 34830069
pii: ijms222212175
doi: 10.3390/ijms222212175
pmc: PMC8620263
pii:
doi:
Substances chimiques
Nucleocytoplasmic Transport Proteins
0
ran GTP-Binding Protein
EC 3.6.5.2
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Références
Neuroscience. 2017 May 14;350:158-168
pubmed: 28344074
EMBO J. 2016 Jun 15;35(12):1276-97
pubmed: 27103069
Cell. 2018 Apr 19;173(3):677-692.e20
pubmed: 29677512
Hum Mutat. 2013 Feb;34(2):363-73
pubmed: 23111906
Elife. 2015 Dec 17;4:
pubmed: 26673895
Nat Struct Mol Biol. 2007 May;14(5):452-4
pubmed: 17435768
Front Aging Neurosci. 2017 Mar 22;9:68
pubmed: 28382000
J Biol Chem. 1969 Nov 25;244(22):6049-55
pubmed: 5389100
Nature. 2015 Sep 3;525(7567):129-33
pubmed: 26308899
Neuron. 2011 Oct 20;72(2):257-68
pubmed: 21944779
Life Sci Alliance. 2018 May 16;1(2):e201800070
pubmed: 30456350
Hum Mol Genet. 2017 Feb 15;26(4):790-800
pubmed: 28040728
Ann Neurol. 2015 Oct;78(4):568-83
pubmed: 26174152
Cell. 2013 Aug 29;154(5):971-982
pubmed: 23993091
EMBO J. 2020 Jan 2;39(1):e101112
pubmed: 31721251
FEBS Lett. 2014 May 21;588(10):1857-68
pubmed: 24780099
Proc Natl Acad Sci U S A. 2012 Jul 24;109(30):12017-21
pubmed: 22778397
Cell. 2009 Jan 23;136(2):284-95
pubmed: 19167330
Curr Neurol Neurosci Rep. 2006 Jan;6(1):37-46
pubmed: 16469270
Neuron. 2014 Dec 17;84(6):1213-25
pubmed: 25521377
Acta Neuropathol Commun. 2018 Aug 3;6(1):72
pubmed: 30075745
Neuron. 2016 Oct 19;92(2):383-391
pubmed: 27720481
Brain. 2014 Jul;137(Pt 7):2040-51
pubmed: 24866055
Nature. 2014 Mar 13;507(7491):195-200
pubmed: 24598541
Science. 2009 Feb 27;323(5918):1208-1211
pubmed: 19251628
Bio Protoc. 2020 Jun 20;10(12):e3659
pubmed: 33659329
J Biol Chem. 2007 Feb 23;282(8):5101-5
pubmed: 17170104
Histochem Cell Biol. 2018 Dec;150(6):593-605
pubmed: 30361777
Lancet Neurol. 2012 Jan;11(1):54-65
pubmed: 22154785
Acta Neuropathol. 2020 Nov;140(5):625-643
pubmed: 32876811
Nat Rev Mol Cell Biol. 2010 Jul;11(7):490-501
pubmed: 20571586
Lancet Neurol. 2012 Apr;11(4):323-30
pubmed: 22406228
Trends Cell Biol. 2008 Oct;18(10):456-66
pubmed: 18786826
N Engl J Med. 2017 Jul 13;377(2):162-172
pubmed: 28700839
EMBO J. 2016 Aug 1;35(15):1656-76
pubmed: 27334615
Biochem Biophys Res Commun. 2002 Jun 7;294(2):354-8
pubmed: 12051719
Sci Transl Med. 2021 Jul 28;13(604):
pubmed: 34321318
Nature. 1993 Mar 4;362(6415):59-62
pubmed: 8446170
Bioinformatics. 2013 Feb 15;29(4):499-503
pubmed: 23329412
Sci Rep. 2018 Mar 15;8(1):4606
pubmed: 29545601
Nat Neurosci. 2021 Aug;24(8):1077-1088
pubmed: 34059832
EMBO J. 2001 Mar 15;20(6):1320-30
pubmed: 11250898
Curr Biol. 2002 Jul 23;12(14):R502-8
pubmed: 12176353
Neuron. 2020 Sep 23;107(6):1124-1140.e11
pubmed: 32673563
Nat Neurosci. 2015 Sep;18(9):1226-9
pubmed: 26308983
Nucleic Acids Res. 2008 Feb;36(2):616-28
pubmed: 18063567
Traffic. 2001 Oct;2(10):684-9
pubmed: 11576444
Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):E1111-E1117
pubmed: 28069952
Neuron. 2011 Oct 20;72(2):245-56
pubmed: 21944778
FEBS Lett. 2017 Jun;591(11):1489-1507
pubmed: 28380257
Nat Rev Neurosci. 2021 Aug;22(8):515
pubmed: 34103711
J Cell Sci. 1997 Aug;110 ( Pt 15):1741-50
pubmed: 9264461
Nat Rev Neurosci. 2021 Aug;22(8):514
pubmed: 34103710
Science. 2009 Feb 27;323(5918):1205-8
pubmed: 19251627
Sci Rep. 2019 Oct 31;9(1):15728
pubmed: 31673013
Cell. 2018 Apr 19;173(3):693-705.e22
pubmed: 29677513
J Neuropathol Exp Neurol. 2009 Nov;68(11):1184-92
pubmed: 19816199
Mol Neurodegener. 2019 Feb 15;14(1):9
pubmed: 30767771
Biochim Biophys Acta. 2010 Jul;1803(7):865-71
pubmed: 20362631
Nature. 2015 Sep 3;525(7567):56-61
pubmed: 26308891
Nat Cell Biol. 2004 Nov;6(11):1114-21
pubmed: 15502822
Hum Mol Genet. 2018 Dec 1;27(23):4103-4116
pubmed: 30379317
Annu Rev Cell Dev Biol. 1999;15:607-60
pubmed: 10611974
Cell Stem Cell. 2015 Dec 3;17(6):705-718
pubmed: 26456686
J Clin Invest. 2015 Jun;125(6):2548
pubmed: 26030230
Hum Mol Genet. 2014 Jul 1;23(13):3579-95
pubmed: 24549040
Cell. 2018 Apr 19;173(3):720-734.e15
pubmed: 29677515
Elife. 2020 Mar 02;9:
pubmed: 32119645
Hum Mol Genet. 2016 May 1;25(9):1803-13
pubmed: 26931465
Nucleic Acids Res. 2009 Oct;37(19):6600-12
pubmed: 19729507
EMBO J. 2002 Feb 1;21(3):377-86
pubmed: 11823430
Annu Rev Biochem. 2019 Jun 20;88:725-783
pubmed: 30883195
EMBO J. 2011 Aug 31;30(17):3457-74
pubmed: 21878989
J Clin Neurol. 2019 Jan;15(1):62-67
pubmed: 30618218
Cell. 2018 Apr 19;173(3):706-719.e13
pubmed: 29677514
Front Mol Neurosci. 2017 Feb 13;10:35
pubmed: 28243191
Cell Rep. 2020 Dec 22;33(12):108538
pubmed: 33357437
Sci Rep. 2016 Feb 12;6:20877
pubmed: 26869068
Mol Cell. 2017 Mar 16;65(6):1044-1055.e5
pubmed: 28306503
Acta Neuropathol. 2019 Jan;137(1):47-69
pubmed: 30450515
EMBO J. 2010 Aug 18;29(16):2841-57
pubmed: 20606625
Nat Rev Neurol. 2018 Sep;14(9):544-558
pubmed: 30120348
Proc Natl Acad Sci U S A. 2004 Aug 31;101(35):12887-92
pubmed: 15306682
Acta Neuropathol. 2010 Mar;119(3):355-64
pubmed: 19967541
Science. 2014 Sep 5;345(6201):1192-1194
pubmed: 25103406
Acta Neuropathol. 2019 Jan;137(1):1-26
pubmed: 30368547
J Neurochem. 2016 Aug;138 Suppl 1:95-111
pubmed: 27015757
Cell. 2016 Oct 20;167(3):774-788.e17
pubmed: 27768896
Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3191-6
pubmed: 11248054
Cell. 2006 Aug 11;126(3):543-58
pubmed: 16901787
Nat Rev Mol Cell Biol. 2009 Mar;10(3):178-91
pubmed: 19234477
Mol Cell. 2004 Nov 5;16(3):319-30
pubmed: 15525506
Cell. 2016 Oct 20;167(3):789-802.e12
pubmed: 27768897
Cell Rep. 2018 Jul 17;24(3):529-537.e4
pubmed: 30021151
Nat Rev Neurosci. 2021 Apr;22(4):197-208
pubmed: 33654312
J Cell Sci. 2015 May 1;128(9):1787-99
pubmed: 25788698
Expert Opin Pharmacother. 2017 May;18(7):735-738
pubmed: 28406335
Acta Neuropathol. 2018 Mar;135(3):459-474
pubmed: 29196813
Trends Biochem Sci. 2016 Jan;41(1):46-61
pubmed: 26705895
Brain. 2018 Oct 1;141(10):2908-2924
pubmed: 30239641
Int J Mol Sci. 2021 Aug 26;22(17):
pubmed: 34502125
J Neurol Neurosurg Psychiatry. 2017 Jul;88(7):540-549
pubmed: 28057713
Annu Rev Biochem. 2007;76:647-71
pubmed: 17506639
Ann Neurol. 2007 May;61(5):427-34
pubmed: 17469116
Nat Neurosci. 2018 Feb;21(2):228-239
pubmed: 29311743
Trends Cell Biol. 2019 Apr;29(4):308-322
pubmed: 30660504
Cell. 2018 May 3;173(4):958-971.e17
pubmed: 29628143
Amyotroph Lateral Scler Frontotemporal Degener. 2014 Dec;15(7-8):557-62
pubmed: 24899262
Science. 2016 Jan 8;351(6269):173-6
pubmed: 26634439
Sci Adv. 2021 Apr 9;7(15):
pubmed: 33837088
Cell. 2003 Apr 18;113(2):195-206
pubmed: 12705868
PeerJ. 2018 Oct 17;6:e5815
pubmed: 30356970
Science. 2006 Oct 6;314(5796):130-3
pubmed: 17023659
PLoS One. 2013 Jun 27;8(6):e68356
pubmed: 23826389
Neuron. 2017 Oct 11;96(2):285-297
pubmed: 29024655
Acta Neuropathol Commun. 2021 Mar 19;9(1):45
pubmed: 33741069
Front Genet. 2012 Dec 13;3:283
pubmed: 23248642