Modeling, Synthesis, and Biological Evaluation of Potential Retinoid-X-Receptor (RXR) Selective Agonists: Analogs of 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahyro-2-naphthyl)ethynyl]benzoic Acid (Bexarotene) and 6-(Ethyl(4-isobutoxy-3-isopropylphenyl)amino)nicotinic Acid (NEt-4IB).

Animals Antineoplastic Agents / chemical synthesis Apolipoproteins E / genetics Bexarotene / analogs & derivatives Cell Line, Tumor Dose-Response Relationship, Drug Gene Expression Humans Leukocytes / drug effects Nicotinic Acids / chemical synthesis Retinoid X Receptor alpha / agonists Structure-Activity Relationship
leukemia retinoid retinoid-X-receptor rexinoid small molecule therapeutic structure–activity relationship

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
16 Nov 2021
Historique:
received: 27 09 2021
revised: 08 11 2021
accepted: 12 11 2021
entrez: 27 11 2021
pubmed: 28 11 2021
medline: 17 12 2021
Statut: epublish

Résumé

Five novel analogs of 6-(ethyl)(4-isobutoxy-3-isopropylphenyl)amino)nicotinic acid-or NEt-4IB-in addition to seven novel analogs of 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (bexarotene) were prepared and evaluated for selective retinoid-X-receptor (RXR) agonism alongside bexarotene (

Identifiants

DOI: 10.3390/ijms222212371 PMID: 34830251 PMC: PMC8624485
pubmed: 34830251
pii: ijms222212371
doi: 10.3390/ijms222212371
pmc: PMC8624485
pii:
doi:

Substances chimiques

Antineoplastic Agents 0
ApoE protein, human 0
Apolipoproteins E 0
Nicotinic Acids 0
RXRA protein, human 0
Retinoid X Receptor alpha 0
Bexarotene A61RXM4375

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NCI NIH HHS
ID : R15 CA249617
Pays : United States
Organisme : NCI NIH HHS
ID : R15 CA139364
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA091842
Pays : United States
Organisme : NIH HHS
ID : R01 HL128447
Pays : United States
Organisme : NIH HHS
ID : 1 R15 CA139364-01A2
Pays : United States
Organisme : NIH HHS
ID : 1R15CA249617-01
Pays : United States

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Auteurs

Peter W Jurutka (PW)

School of Mathematical and Natural Sciences, Arizona State University, Glendale, AZ 85306, USA.
Basic Medical Sciences, University of Arizona College of Medicine, Phoenix, AZ 85004, USA.
ORCID: 0000-0002-4950-9161

Orsola di Martino (O)

Department of Internal Medicine, Washington University, St. Louis, MO 63110, USA.
ORCID: 0000-0002-7620-0290

Sabeeha Reshi (S)

School of Mathematical and Natural Sciences, Arizona State University, Glendale, AZ 85306, USA.

Sanchita Mallick (S)

School of Mathematical and Natural Sciences, Arizona State University, Glendale, AZ 85306, USA.

Zhela L Sabir (ZL)

School of Mathematical and Natural Sciences, Arizona State University, Glendale, AZ 85306, USA.

Lech J P Staniszewski (LJP)

School of Mathematical and Natural Sciences, Arizona State University, Glendale, AZ 85306, USA.

Ankedo Warda (A)

School of Mathematical and Natural Sciences, Arizona State University, Glendale, AZ 85306, USA.
Basic Medical Sciences, University of Arizona College of Medicine, Phoenix, AZ 85004, USA.

Emma L Maiorella (EL)

School of Mathematical and Natural Sciences, Arizona State University, Glendale, AZ 85306, USA.

Ani Minasian (A)

School of Mathematical and Natural Sciences, Arizona State University, Glendale, AZ 85306, USA.

Jesse Davidson (J)

School of Mathematical and Natural Sciences, Arizona State University, Glendale, AZ 85306, USA.

Samir J Ibrahim (SJ)

School of Mathematical and Natural Sciences, Arizona State University, Glendale, AZ 85306, USA.

San Raban (S)

School of Mathematical and Natural Sciences, Arizona State University, Glendale, AZ 85306, USA.

Dena Haddad (D)

School of Mathematical and Natural Sciences, Arizona State University, Glendale, AZ 85306, USA.

Madleen Khamisi (M)

School of Mathematical and Natural Sciences, Arizona State University, Glendale, AZ 85306, USA.

Stephanie L Suban (SL)

School of Mathematical and Natural Sciences, Arizona State University, Glendale, AZ 85306, USA.

Bradley J Dawson (BJ)

School of Mathematical and Natural Sciences, Arizona State University, Glendale, AZ 85306, USA.

Riley Candia (R)

School of Mathematical and Natural Sciences, Arizona State University, Glendale, AZ 85306, USA.

Joseph W Ziller (JW)

Department of Chemistry, University of California, Irvine, CA 92697, USA.

Ming-Yue Lee (MY)

School of Molecular Sciences, Arizona State University, Tempe, AZ 85201, USA.
ORCID: 0000-0001-7082-1216

Chang Liu (C)

School of Molecular Sciences, Arizona State University, Tempe, AZ 85201, USA.

Wei Liu (W)

School of Molecular Sciences, Arizona State University, Tempe, AZ 85201, USA.

Pamela A Marshall (PA)

School of Mathematical and Natural Sciences, Arizona State University, Glendale, AZ 85306, USA.
ORCID: 0000-0002-3530-4368

John S Welch (JS)

Department of Internal Medicine, Washington University, St. Louis, MO 63110, USA.
ORCID: 0000-0001-6656-3672

Carl E Wagner (CE)

School of Mathematical and Natural Sciences, Arizona State University, Glendale, AZ 85306, USA.

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