Molecular Response to Combined Molecular- and External Radiotherapy in Head and Neck Squamous Cell Carcinoma (HNSCC).

Cetuximab DNA damage response cell death induction external beam radiotherapy molecular targeted radiotherapy

Journal

Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829

Informations de publication

Date de publication:
09 Nov 2021
Historique:
received: 23 10 2021
accepted: 03 11 2021
entrez: 27 11 2021
pubmed: 28 11 2021
medline: 28 11 2021
Statut: epublish

Résumé

Combination treatment of molecular targeted and external radiotherapy is a promising strategy and was shown to improve local tumor control in a HNSCC xenograft model. To enhance the therapeutic value of this approach, this study investigated the underlying molecular response. Subcutaneous HNSCC FaDu

Identifiants

DOI: 10.3390/cancers13225595 PMID: 34830750 PMC: PMC8615625
pubmed: 34830750
pii: cancers13225595
doi: 10.3390/cancers13225595
pmc: PMC8615625
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Federal Ministry of Education and Research
ID : BMBF 03ZIK/OncoRay
Organisme : Deutsche Forschungsgemeinschaft
ID : DFG Ba 1433/5
Organisme : Faculty of Medicine Carl Gustav Carus, TU Dresden in part by the 6th framework EU-project ''BioCare"
ID : #505785

Références

Strahlenther Onkol. 2012 Sep;188(9):823-32
pubmed: 22875052
Nat Methods. 2012 Jun 28;9(7):676-82
pubmed: 22743772
Sci Rep. 2017 Dec 4;7(1):16878
pubmed: 29203879
Oncotarget. 2018 Jul 6;9(52):29985-30004
pubmed: 30042828
Oncogene. 2003 Nov 20;22(52):8536-40
pubmed: 14627995
Pharmaceuticals (Basel). 2014 Mar 05;7(3):311-38
pubmed: 24603603
Radiother Oncol. 2021 Feb;155:285-292
pubmed: 33227356
Mol Cancer Ther. 2010 Aug;9(8):2297-308
pubmed: 20682654
Mutat Res. 2010 Apr-Jun;704(1-3):12-20
pubmed: 20096807
FEBS Lett. 2010 Sep 24;584(18):3878-84
pubmed: 20692258
Radiother Oncol. 2006 Nov;81(2):122-9
pubmed: 16956683
Int J Radiat Oncol Biol Phys. 2001 Feb 1;49(2):427-33
pubmed: 11173137
Cancers (Basel). 2021 Mar 10;13(6):
pubmed: 33801853
J Nucl Med. 2015 Aug;56(8):1239-45
pubmed: 26045312
Nat Protoc. 2009;4(1):44-57
pubmed: 19131956
Nucleic Acids Res. 2003 Sep 1;31(17):4959-64
pubmed: 12930944
Int J Radiat Oncol Biol Phys. 2001 Oct 1;51(2):483-93
pubmed: 11567825
J R Soc Interface. 2016 Mar;13(116):
pubmed: 26935806
Cell Mol Life Sci. 2008 May;65(10):1566-84
pubmed: 18259690
Cancer Res. 2011 Feb 1;71(3):1103-14
pubmed: 21266349
Radiother Oncol. 2011 Jul;100(1):137-44
pubmed: 21821302
Clin Cancer Res. 2000 Feb;6(2):701-8
pubmed: 10690556
Nat Rev Clin Oncol. 2019 Nov;16(11):669-683
pubmed: 31189965
J Nucl Med. 2009 Jan;50(1):123-31
pubmed: 19091906
Biochim Biophys Acta. 1996 Nov 8;1314(1-2):147-56
pubmed: 8972728
Radiother Oncol. 2014 Feb;110(2):362-9
pubmed: 24440046
J Histochem Cytochem. 2002 Feb;50(2):197-204
pubmed: 11799138
CA Cancer J Clin. 2021 May;71(3):209-249
pubmed: 33538338
Leuk Res. 2005 Nov;29(11):1237-8
pubmed: 15946739
Br J Radiol. 2015 Jul;88(1051):20150042
pubmed: 25782328
Lancet Oncol. 2010 Jan;11(1):21-8
pubmed: 19897418
Radiother Oncol. 2019 Oct;139:94-100
pubmed: 31445839
Nat Rev Drug Discov. 2020 Sep;19(9):589-608
pubmed: 32728208
Radiother Oncol. 1994 Aug;32(2):137-43
pubmed: 7972907
Clin Cancer Res. 2007 Apr 15;13(8):2512-8
pubmed: 17438112
Eur J Nucl Med Mol Imaging. 2020 Apr;47(4):849-859
pubmed: 31705176
Clin Cancer Res. 2004 Dec 1;10(23):7792-8
pubmed: 15585610
Int J Cancer. 2014 Aug 15;135(4):968-80
pubmed: 24615356
Nucleic Acids Res. 2021 Jan 8;49(D1):D545-D551
pubmed: 33125081
BMC Mol Biol. 2007 Apr 25;8:29
pubmed: 17459151
Int J Radiat Biol. 2014 Aug;90(8):678-86
pubmed: 24597752
J Biol Chem. 2005 Sep 2;280(35):31182-9
pubmed: 16000298
Int J Radiat Oncol Biol Phys. 2006 Dec 1;66(5):1506-14
pubmed: 17069989
Semin Nucl Med. 2008 Sep;38(5):358-66
pubmed: 18662557
Anal Chem. 2015 Apr 21;87(8):4110-6
pubmed: 25837572
Mol Cancer Ther. 2010 Jul;9(7):2102-13
pubmed: 20587660
Radiother Oncol. 2004 Jul;72(1):95-101
pubmed: 15236881
Curr Drug Discov Technol. 2010 Dec;7(4):263-79
pubmed: 21034408
Nat Commun. 2019 Jul 4;10(1):2954
pubmed: 31273204
J Nucl Med. 2016 Jul;57(7):1105-11
pubmed: 26917708
Int J Radiat Oncol Biol Phys. 1988 Sep;15(3):691-7
pubmed: 3417489
EMBO J. 2017 Aug 1;36(15):2280-2295
pubmed: 28607003
Radiother Oncol. 2005 Aug;76(2):162-7
pubmed: 16024114
PLoS Biol. 2020 Jul 14;18(7):e3000410
pubmed: 32663219
Radiother Oncol. 2017 Sep;124(3):379-385
pubmed: 28739384
J Nucl Med. 2007 Sep;48(9):1562-70
pubmed: 17704253
Genes (Basel). 2020 Jan 15;11(1):
pubmed: 31952359
N Engl J Med. 2006 Feb 9;354(6):567-78
pubmed: 16467544
J Clin Oncol. 2007 Sep 10;25(26):4066-74
pubmed: 17827455
Nat Rev Cancer. 2009 Jun;9(6):400-14
pubmed: 19440234
Int J Mol Sci. 2015 Dec 28;17(1):
pubmed: 26729091

Auteurs

Treewut Rassamegevanon (T)

German Cancer Consortium (DKTK), Partner Site Dresden, and German Cancer Research Center (DKFZ), 69192 Heidelberg, Germany.
German Cancer Research Center (DKFZ), 69192 Heidelberg, Germany.
OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, 01307 Dresden, Germany.
ORCID: 0000-0001-8193-1103

Louis Feindt (L)

OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, 01307 Dresden, Germany.
Department of Radiotherapy and Radiation Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany.

Lydia Koi (L)

OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, 01307 Dresden, Germany.
Department of Radiotherapy and Radiation Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany.
Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiooncology-OncoRay, 01328 Dresden, Germany.

Johannes Müller (J)

OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, 01307 Dresden, Germany.
Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiooncology-OncoRay, 01328 Dresden, Germany.

Robert Freudenberg (R)

Department of Nuclear Medicine, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany.

Steffen Löck (S)

German Cancer Consortium (DKTK), Partner Site Dresden, and German Cancer Research Center (DKFZ), 69192 Heidelberg, Germany.
German Cancer Research Center (DKFZ), 69192 Heidelberg, Germany.
OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, 01307 Dresden, Germany.
Department of Radiotherapy and Radiation Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany.
ORCID: 0000-0002-7017-3738

Wiebke Sihver (W)

Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, 01328 Dresden, Germany.

Enes Çevik (E)

OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, 01307 Dresden, Germany.
Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiooncology-OncoRay, 01328 Dresden, Germany.
School of Medicine, Koç University, Istanbul 34450, Turkey.
ORCID: 0000-0002-1240-6150

Ariane Christel Kühn (AC)

OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, 01307 Dresden, Germany.
B CUBE-Center for Molecular Bioengineering, Technische Universität Dresden, 01307 Dresden, Germany.

Cläre von Neubeck (C)

German Cancer Consortium (DKTK), Partner Site Dresden, and German Cancer Research Center (DKFZ), 69192 Heidelberg, Germany.
German Cancer Research Center (DKFZ), 69192 Heidelberg, Germany.
OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, 01307 Dresden, Germany.
Department of Particle Therapy, University Hospital Essen, University of Duisburg-Essen, 45147 Essen, Germany.
ORCID: 0000-0003-2955-1626

Annett Linge (A)

German Cancer Consortium (DKTK), Partner Site Dresden, and German Cancer Research Center (DKFZ), 69192 Heidelberg, Germany.
German Cancer Research Center (DKFZ), 69192 Heidelberg, Germany.
OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, 01307 Dresden, Germany.
Department of Radiotherapy and Radiation Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany.
National Center for Tumor Diseases (NCT), Partner Site Dresden, 01307 Dresden, Germany.
ORCID: 0000-0001-9636-1721

Hans-Jürgen Pietzsch (HJ)

Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, 01328 Dresden, Germany.

Jörg Kotzerke (J)

Department of Nuclear Medicine, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany.

Michael Baumann (M)

German Cancer Research Center (DKFZ), 69192 Heidelberg, Germany.
OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, 01307 Dresden, Germany.
ORCID: 0000-0002-9340-974X

Mechthild Krause (M)

German Cancer Consortium (DKTK), Partner Site Dresden, and German Cancer Research Center (DKFZ), 69192 Heidelberg, Germany.
German Cancer Research Center (DKFZ), 69192 Heidelberg, Germany.
OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, 01307 Dresden, Germany.
Department of Radiotherapy and Radiation Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany.
Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiooncology-OncoRay, 01328 Dresden, Germany.
National Center for Tumor Diseases (NCT), Partner Site Dresden, 01307 Dresden, Germany.

Antje Dietrich (A)

German Cancer Consortium (DKTK), Partner Site Dresden, and German Cancer Research Center (DKFZ), 69192 Heidelberg, Germany.
German Cancer Research Center (DKFZ), 69192 Heidelberg, Germany.
OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, 01307 Dresden, Germany.

Classifications MeSH